Logo of jexpmedHomeThe Rockefeller University PressEditorsContactInstructions for AuthorsThis issue
J Exp Med. Aug 1, 1983; 158(2): 378–392.
PMCID: PMC2187334

Serum transfer of collagen-induced arthritis in mice

Abstract

Immunization of DBA/1 mice with native chick type II collagen resulted in development of polyarthritis 4-5 wk later. Sera of these mice contained high levels of anticollagen antibodies, and immunoglobulin concentrates of their sera transferred arthritis to unimmunized recipients. Histopathologically, this passively transferred arthritis resembled the early disease of immunized donors. Immunofluorescence studies demonstrated the deposition of IgG and C3 on the articular surface but not in synovial tissue of arthritic joints. Transferred, isotopically labeled anticollagen antibodies rapidly localized to the limbs and to other cartilage-containing tissues. When transfer concentrate was administered to arthritis-resistant strains, they also developed arthritis. Indeed, immunoglobulin concentrates from rats with collagen-induced arthritis transferred arthritis to naive mice. The amount of concentrate required for transfer to B10.D2 resistant mice was reduced by immunizing them with collagen 4 wk before transfer. Although susceptibility to arthritis from immunization is H-2 linked, these studies clearly demonstrate that passive transfer of arthritis depends upon injection of specific antibody and not on other host factors.

Full Text

The Full Text of this article is available as a PDF (1.5M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Trentham DE, Townes AS, Kang AH. Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med. 1977 Sep 1;146(3):857–868. [PMC free article] [PubMed]
  • Trentham DE, Townes AS, Kang AH, David JR. Humoral and cellular sensitivity to collagen in type II collagen-induced arthritis in rats. J Clin Invest. 1978 Jan;61(1):89–96. [PMC free article] [PubMed]
  • STEFFEN C, TIMPL R. Antigenicity of collagen and its application in the serological investigation of rheumatoid arthritis sera. Int Arch Allergy Appl Immunol. 1963;22:333–349. [PubMed]
  • Andriopoulos NA, Mestecky J, Miller EJ, Bradley EL. Antibodies to native and denatured collagens in sera of patients with rheumatoid arthritis. Arthritis Rheum. 1976 May-Jun;19(3):613–617. [PubMed]
  • Trentham DE, Dynesius RA, Rocklin RE, David JR. Cellular sensitivity to collagen in rheumatoid arthritis. N Engl J Med. 1978 Aug 17;299(7):327–332. [PubMed]
  • Trentham DE. Collagen arthritis as a relevant model for rheumatoid arthritis. Arthritis Rheum. 1982 Aug;25(8):911–916. [PubMed]
  • Gay S, Gay RE, Miller EF. The collagens of the joint. Arthritis Rheum. 1980 Aug;23(8):937–941. [PubMed]
  • Stuart JM, Cremer MA, Dixit SN, Kang AH, Townes AS. Collagen-induced arthritis in rats. Comparison of vitreous and cartilage-derived collagens. Arthritis Rheum. 1979 Apr;22(4):347–352. [PubMed]
  • Trentham DE, Dynesius RA, David JR. Passive transfer by cells of type II collagen-induced arthritis in rats. J Clin Invest. 1978 Aug;62(2):359–366. [PMC free article] [PubMed]
  • Stuart JM, Cremer MA, Townes AS, Kang AH. Type II collagen-induced arthritis in rats. Passive transfer with serum and evidence that IgG anticollagen antibodies can cause arthritis. J Exp Med. 1982 Jan 1;155(1):1–16. [PMC free article] [PubMed]
  • Courtenay JS, Dallman MJ, Dayan AD, Martin A, Mosedale B. Immunisation against heterologous type II collagen induces arthritis in mice. Nature. 1980 Feb 14;283(5748):666–668. [PubMed]
  • Wooley PH, Luthra HS, Stuart JM, David CS. Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates. J Exp Med. 1981 Sep 1;154(3):688–700. [PMC free article] [PubMed]
  • Solinger AM, Bhatnagar R, Stobo JD. Cellular, molecular, and genetic characteristics of T cell reactivity to collagen in man. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3877–3881. [PMC free article] [PubMed]
  • Stastny P, Fink CW. Different HLA-D associations in adult and juvenile rheumatoid arthritis. J Clin Invest. 1979 Jan;63(1):124–130. [PMC free article] [PubMed]
  • Cremer MA, Stuart JM, Townes AS, Kang AH. Collagen-induced polyarthritis in rats: a study of native type II collagen for adjuvant activity. J Immunol. 1980 Jun;124(6):2912–2918. [PubMed]
  • Rogers MP, Trentham DE, McCune WJ, Ginsberg BI, Rennke HG, Reich P, David JR. Effect of psychological stress on the induction of arthritis in rats. Arthritis Rheum. 1980 Dec;23(12):1337–1342. [PubMed]
  • Stuart JM, Townes AS, Kang AH. Nature and specificity of the immune response to collagen in type II collagen-induced arthritis in mice. J Clin Invest. 1982 Mar;69(3):673–683. [PMC free article] [PubMed]
  • Morgan K, Clague RB, Shaw MJ, Firth SA, Twose TM, Holt PJ. Native type II collagen--induced arthritis in the rat: the effect of complement depletion by cobra venom factor. Arthritis Rheum. 1981 Nov;24(11):1356–1362. [PubMed]
  • Theofilopoulos AN, Carson DA, Tavassoli M, Slovin SF, Speers WC, Jensen FB, Vaughan JH. Evidence for the presence of receptors for C3 and IgG Fc on human synovial cells. Arthritis Rheum. 1980 Jan;23(1):1–9. [PubMed]
  • Stuart JM, Cremer MA, Dixit SN, Kang AH, Townes AS. Collagen-induced arthritis in rats. Comparison of vitreous and cartilage-derived collagens. Arthritis Rheum. 1979 Apr;22(4):347–352. [PubMed]
  • Yoo TJ, Tomoda K, Stuart JM, Kang AH, Townes AS. Type II collagen-induced autoimmune otospongiosis. A preliminary report. Ann Otol Rhinol Laryngol. 1983 Mar-Apr;92(2 Pt 1):103–108. [PubMed]
  • Rosenwasser LJ, Bhatnagar RS, Stobo JD. Genetic control of the murine T lymphocyte proliferative response to collagen: analysis of the molecular and cellular contributions to immunogenicity. J Immunol. 1980 Jun;124(6):2854–2859. [PubMed]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...