Logo of jexpmedHomeThe Rockefeller University PressEditorsContactInstructions for AuthorsThis issue
J Exp Med. Sep 1, 1981; 154(3): 688–700.
PMCID: PMC2186443

Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates

Abstract

A model of arthritis was established by the injection of type II collagen into mice. Only mice bearing the H-2q haplotype were susceptible to the disease. Susceptibility was further mapped by the use of recombinant strains on the Iq locus. Type II collagen arthritis was observed in the (resistant X susceptible) F1 cross. Mice strains were designated high, intermediate, or low responders with respect to the anti-type II antibody levels measured by radioimmunoassay. Arthritis-susceptible strains were all classified as high antibody responders. The clinical and histological appearance of type II collagen arthritis in the mouse indicates that it may be a good animal model for the investigation of various immunogenetic traits in rheumatoid arthritis.

Full Text

The Full Text of this article is available as a PDF (2.9M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Trentham DE, Townes AS, Kang AH. Autoimmunity to type II collagen an experimental model of arthritis. J Exp Med. 1977 Sep 1;146(3):857–868. [PMC free article] [PubMed]
  • Trentham DE, Dynesius RA, David JR. Passive transfer by cells of type II collagen-induced arthritis in rats. J Clin Invest. 1978 Aug;62(2):359–366. [PMC free article] [PubMed]
  • Andriopoulos NA, Mestecky J, Miller EJ, Bradley EL. Antibodies to native and denatured collagens in sera of patients with rheumatoid arthritis. Arthritis Rheum. 1976 May-Jun;19(3):613–617. [PubMed]
  • Clague RB, Shaw MJ, Holt PJ. Incidence of serum antibodies to native type I and type II collagens in patients with inflammatory arthritis. Ann Rheum Dis. 1980 Jun;39(3):201–206. [PMC free article] [PubMed]
  • Trentham DE, Dynesius RA, Rocklin RE, David JR. Cellular sensitivity to collagen in rheumatoid arthritis. N Engl J Med. 1978 Aug 17;299(7):327–332. [PubMed]
  • LILLY F, BOYSE EA, OLD LJ. GENETIC BASIS OF SUSCEPTIBILITY TO VIRAL LEUKAEMOGENESIS. Lancet. 1964 Dec 5;2(7371):1207–1209. [PubMed]
  • McDevitt HO, Bodmer WF. Protein clinical manifestations of primary tumors of the heart. Am J Med. 1972 Jan;52(1):1–8. [PubMed]
  • McDevitt HO, Sela M. Genetic control of the antibody response. I. Demonstration of determinant-specific differences in response to synthetic polypeptide antigens in two strains of inbred mice. J Exp Med. 1965 Sep 1;122(3):517–531. [PMC free article] [PubMed]
  • Benacerraf B, McDevitt HO. Histocompatibility-linked immune response genes. Science. 1972 Jan 21;175(4019):273–279. [PubMed]
  • Courtenay JS, Dallman MJ, Dayan AD, Martin A, Mosedale B. Immunisation against heterologous type II collagen induces arthritis in mice. Nature. 1980 Feb 14;283(5748):666–668. [PubMed]
  • Cremer MA, Stuart JM, Townes AS, Kang AH. Collagen-induced polyarthritis in rats: a study of native type II collagen for adjuvant activity. J Immunol. 1980 Jun;124(6):2912–2918. [PubMed]
  • Clague RB, Brown RA, Weiss JB, Holt PJ. Solid-phase radioimmunoassay for the detection of antibodies to collagen. J Immunol Methods. 1979 May 10;27(1):31–41. [PubMed]
  • Hahn E, Nowack H, GOTZE D, Timpl R. H-2-linked genetic control of antibody response to soluble calf skin collagen in mice. Eur J Immunol. 1975 Apr;5(4):288–291. [PubMed]
  • Hedrick SM, Watson JD. Genetic control of the immune response to collagen. I. Quantitative determination of response levels by multiple I-region genes. J Immunogenet. 1980 Jun;7(3):271–283. [PubMed]
  • Rosenwasser LJ, Bhatnagar RS, Stobo JD. Genetic control of the murine T lymphocyte proliferative response to collagen: analysis of the molecular and cellular contributions to immunogenicity. J Immunol. 1980 Jun;124(6):2854–2859. [PubMed]
  • Rohde H, Nowack H, Timpl R. Localization of antigenic activity and immunogenic capacity in different conformational domains of procollagen peptide. Eur J Immunol. 1978 Feb;8(2):141–143. [PubMed]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Gene
    Gene
    Gene links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...