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J Exp Med. 1979 Mar 1; 149(3): 601–612.
PMCID: PMC2184824

Genetically determined, interferon-dependent resistance to influenza virus in mice


The genetically determined resistance towards orthomyxoviruses exhibited by mice homozygous (A2G) or heterozygous (A2G X A/J) for the gene Mx was abolished or greatly diminished by treatment with anti- interferon globulin (AIF). AIF induced increased susceptibility to challenge with hepatotropic, neurotropic, and pneumotropic strains of influenza A virus. Hepatotropic virus titers in blood and livers of AIF- treated, Mx-bearing mice were higher by a factor of 10(3)--10(6) than those in untreated mice of the same genotype, and were comparable to those in genetically susceptible (untreated or AIF-treated) mice. Peritoneal macrophages from Mx-bearing untreated mice were resistant to challenge with a macrophage-adapted strain of influenza A virus even in the presence of AIF. However, when macrophages were taken from resistant mice injected with AIF and also cultivated in the presence of AIF, they were as susceptible to the virus as macrophages taken from susceptible mice. We conclude that interferons is an important factor in resistance to orthomyxoviruses governed by the gene Mx.

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Selected References

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  • Lindenmann J, Deuel E, Fanconi S, Haller O. Inborn resistance of mice to myxoviruses: macrophages express phenotype in vitro. J Exp Med. 1978 Feb 1;147(2):531–540. [PMC free article] [PubMed]
  • Haller O, Arnheiter H, Lindenmann J. Genetically determined resistance to infection by hepatotropic influenza A virus in mice: effect of immunosuppression. Infect Immun. 1976 Mar;13(3):844–854. [PMC free article] [PubMed]
  • Fiske RA, Klein PA. Effect of immunosuppression on the genetic resistance of A2G mice to neurovirulent influenza virus. Infect Immun. 1975 Mar;11(3):576–587. [PMC free article] [PubMed]
  • Haller O, Lindenmann J. Athymic (nude) mice express gene for myxovirus resistance. Nature. 1974 Aug 23;250(5468):679–680. [PubMed]
  • Gresser I, Tovey MG, Bandu ME, Maury C, Brouty-Boyé D. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. J Exp Med. 1976 Nov 2;144(5):1305–1315. [PMC free article] [PubMed]
  • Virelizier JL, Gresser I. Role of interferon in the pathogenesis of viral diseases of mice as demonstrated by the use of anti-interferon serum. V. Protective role in mouse hepatitis virus type 3 infection of susceptible and resistant strains of mice. J Immunol. 1978 May;120(5):1616–1619. [PubMed]
  • Pereira HG, Tůmová B, Law VG. Avian influenza A viruses. Bull World Health Organ. 1965;32(6):855–860. [PMC free article] [PubMed]
  • Haller O. A mouse hepatotropic variant of influenza virus. Arch Virol. 1975;49(2-3):99–116. [PubMed]
  • Haller O, Lindenmann J. Host-cell antigen potentiated by incomplete growth cycle of influenza virus. J Natl Cancer Inst. 1975 Feb;54(2):459–464. [PubMed]
  • Mogensen KE, Pyhälä L, Cantell K. Raising antibodies to human leukocyte interferon. Acta Pathol Microbiol Scand B. 1975 Oct;83(5):443–450. [PubMed]
  • Tovey MG, Begon-Lours J, Gresser I. A method for the large scale production of potent interferon preparations. Proc Soc Exp Biol Med. 1974 Jul;146(3):809–815. [PubMed]
  • Gresser I, Tovey MG, Maury C, Bandu MT. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with herpes simplex, Moloney sarcoma, vesicular stomatitis, Newcastle disease, and influenza viruses. J Exp Med. 1976 Nov 2;144(5):1316–1323. [PMC free article] [PubMed]
  • ISAACS A, HITCHCOCK G. Role of interferon in recovery from virus infections. Lancet. 1960 Jul 9;2(7141):69–71. [PubMed]
  • Fauconnier B. Augmentation de la pathogénicité virale par l'emploi de sérum anti-interféron in vivo. C R Acad Sci Hebd Seances Acad Sci D. 1970 Oct 19;271(16):1464–1466. [PubMed]
  • Inglot AD, Chudzio T. Enchancement of leukemogenesis in mice after prolonged administration of anti-interferon or normal rabbit globulin. Arch Virol. 1977;55(1-2):67–75. [PubMed]
  • Gresser I, Lang DJ. Relationships between viruses and leucocytes. Prog Med Virol. 1966;8:62–130. [PubMed]
  • Darnell MB, Koprowski H. Genetically determined resistance to infection with group B arboviruses. II. Increased production of interfering particles in cell cultures from resistant mice. J Infect Dis. 1974 Mar;129(3):248–256. [PubMed]
  • Stewart WE, 2nd, Scott WD, Sulkin SE. Relative sensitivities of viruses to different species of interferon. J Virol. 1969 Aug;4(2):147–153. [PMC free article] [PubMed]
  • Youngner JS, Thacore HR, Kelly ME. Sensitivity of ribonucleic acid and deoxyribonucleic acid viruses to different species of interferon in cell cultures. J Virol. 1972 Aug;10(2):171–178. [PMC free article] [PubMed]

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