• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of anesthprogLink to Publisher's site
Anesth Prog. 1985 Nov-Dec; 32(6): 232–236.
PMCID: PMC2175420

Double-Blind Comparison of Rectally Administered Diazepam to Placebo for Pediatric Sedation: The Cardiovascular Response

Abstract

The sedative and cardiovascular effects of rectally administered diazepam (0.6 mg/kg) were compared to placebo in uncooperative children who required sedation during dental treatment. Twelve healthy preschool children, who required amalgam restorations, were treated during two standardized restorative appointments in a double-blind, crossover study. Blood pressure and pulse were obtained during four specified intervals during the appointment. The behavior of the children during the treatment visits was videotaped and later statistically analyzed using a kinesics/vocalization instrument. Behavioral ratings of cooperation were significantly improved during the treatment visit following diazepam. All interfering bodily movements, patient vocalizations and operator commands for the diazepam group were reduced significantly (p≤0.0001). No significant differences were observed for noninterfering behavioral response. Rectally administered diazepam did not alter blood pressure or pulse significantly in these sedated children when compared to the placebo. These findings indicate that rectal diazepam is an effective sedative agent with minimal effect on the cardiovascular system for the management of the young pediatric dental patient.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (816K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Lundgren S, Ekman A, Blombäck U. Rectal administration of diazepam in solution. A clinical study on sedation in paediatric dentistry. Swed Dent J. 1978;2(5):161–166. [PubMed]
  • Dulac O, Aicardi J, Rey E, Olive G. Blood levels of diazepam after single rectal administration in infants and children. J Pediatr. 1978 Dec;93(6):1039–1041. [PubMed]
  • Agurell S, Berlin A, Ferngren H, Hellström B. Plasma levels of diazepam after parenteral and rectal administration in children. Epilepsia. 1975 Jun;16(2):277–283. [PubMed]
  • Knudsen FU. Plasma-diazepam in infants after rectal administration in solution and by suppository. Acta Paediatr Scand. 1977 Sep;66(5):563–567. [PubMed]
  • Lundgren S, Rosenquist JB. Comparison of sedation, amnesia, and patient comfort produced by intravenous and rectal diazepam. J Oral Maxillofac Surg. 1984 Oct;42(10):646–650. [PubMed]
  • Venham L, Quatrocelli S. The young child's response to repeated dental procedures. J Dent Res. 1977 Jul;56(7):734–738. [PubMed]
  • Howitt JW, Stricker G. Sequential changes in response to dental procedures. J Dent Res. 1970 Sep-Oct;49(5):1074–1077. [PubMed]
  • Blom H, Schmidt JF, Rytlander M. Rectal diazepam compared to intramuscular pethidine/promethazine/chlorpromazine with regard to gastric contents in paediatric anaesthesia. Acta Anaesthesiol Scand. 1984 Dec;28(6):652–653. [PubMed]
  • Mattila MA, Ruoppi MK, Ahlström-Bengs E, Larni HM, Pekkola PO. Diazepam in rectal solution as premedication in children, with special reference to serum concentrations. Br J Anaesth. 1981 Dec;53(12):1269–1272. [PubMed]
  • Ahn NC, Andersen GW, Thomsen A, Valentin N. Preanaesthetic medication with rectal diazepam in children. Acta Anaesthesiol Scand. 1981 Apr;25(2):158–160. [PubMed]
  • Meberg A, Langslet A, Bredesen JE, Lunde PK. Plasma concentration of diazepam and N-desmethyldiazepam in children after a single rectal or intramuscular dose of diazepam. Eur J Clin Pharmacol. 1978 Dec 1;14(4):273–276. [PubMed]
  • Langslet A, Meberg A, Bredesen JE, Lunde PK. Plasma concentrations of diazepam and N-desmethyldiazepam in newborn infants after intravenous, intramuscular, rectal and oral administration. Acta Paediatr Scand. 1978 Nov;67(6):699–704. [PubMed]

Articles from Anesthesia Progress are provided here courtesy of American Dental Society of Anesthesiology

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...