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Br J Cancer. 1998 Apr; 77(7): 1186–1189.
PMCID: PMC2150141

Schistosomiasis and the risk of bladder cancer in Alexandria, Egypt.


The relationship between history of schistosomiasis and bladder cancer risk was investigated using data from a case-control study conducted between January 1994 and July 1996 in Alexandria, Egypt. Cases were 190 subjects with incident, histologically confirmed invasive cancer of the bladder, and controls were 187 subjects admitted to hospital for acute, non-neoplastic, non-urinary tract conditions. Eighty-six cases (45%) vs 69 controls (37%) reported a history of urinary schistosomiasis. The corresponding multivariate odds ratio (OR) of bladder cancer -- after allowance for age, sex, education, smoking, other urinary infections and high-risk occupations -- was 1.72 (95% confidence interval (CI) 1.0-2.9). The ORs were 0.22 (95% CI 0.1-0.4) for intestinal schistosomiasis and 0.32 (95% CI 0.1-1.9) for schistosomiasis of other types. The OR for urinary schistosomiasis was higher in subjects who were younger at first diagnosis (OR of 3.3 for <15 years) and in those with a long time since first diagnosis (OR of 3.0 for > or = 35 years). The ORs were 15.8 for male ever-smokers with a history of urinary schistosomiasis, compared with never-smokers without such a history, and 3.2 for men ever-infected with urinary Schistosoma haematobium and ever-employed in high-risk occupations, compared with those never-infected and with no high-risk occupational history. This study confirms that clinical history of urinary schistosomiasis is significantly, but modestly, associated with increased bladder cancer risk, explaining some 16% of bladder cancer cases in this Egyptian population.

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  • Badawi AF, Mostafa MH, Probert A, O'Connor PJ. Role of schistosomiasis in human bladder cancer: evidence of association, aetiological factors, and basic mechanisms of carcinogenesis. Eur J Cancer Prev. 1995 Feb;4(1):45–59. [PubMed]
  • Bedwani R, el-Khwsky F, La Vecchia C, Boffetta P, Levi F. Descriptive epidemiology of bladder cancer in Egypt. Int J Cancer. 1993 Sep 9;55(2):351–352. [PubMed]
  • Bedwani R, el-Khwsky F, Renganathan E, Braga C, Abu Seif HH, Abul Azm T, Zaki A, Franceschi S, Boffetta P, La Vecchia C. Epidemiology of bladder cancer in Alexandria, Egypt: tobacco smoking. Int J Cancer. 1997 Sep 26;73(1):64–67. [PubMed]
  • Bruzzi P, Green SB, Byar DP, Brinton LA, Schairer C. Estimating the population attributable risk for multiple risk factors using case-control data. Am J Epidemiol. 1985 Nov;122(5):904–914. [PubMed]
  • Cheever AW. Schistosomiasis and neoplasia. J Natl Cancer Inst. 1978 Jul;61(1):13–18. [PubMed]
  • Day NE, Brown CC. Multistage models and primary prevention of cancer. J Natl Cancer Inst. 1980 Apr;64(4):977–989. [PubMed]
  • El-Bolkainy MN, Chu EW, Ghoneim MA, Ibrahim AS. Cytologic detection of bladder cancer in a rural Egyptian population infected with schistosomiasis. Acta Cytol. 1982 May-Jun;26(3):303–310. [PubMed]
  • Gelfand M, Weinberg RW, Castle WM. Relation between carcinoma of the bladder and infestation with Schistosoma haematobium. Lancet. 1967 Jun 10;1(7502):1249–1251. [PubMed]
  • Kelly JP, Rosenberg L, Kaufman DW, Shapiro S. Reliability of personal interview data in a hospital-based case-control study. Am J Epidemiol. 1990 Jan;131(1):79–90. [PubMed]
  • La Vecchia C, Lucchini F, Negri E, Boyle P, Levi F. Trends in cancer mortality, 1955-1989: Asia, Africa and Oceania. Eur J Cancer. 1993;29A(15):2168–2211. [PubMed]
  • Lucas SB. Squamous cell carcinoma of the bladder and schistosomiasis. East Afr Med J. 1982 May;59(5):345–351. [PubMed]
  • Matanoski GM, Elliott EA. Bladder cancer epidemiology. Epidemiol Rev. 1981;3:203–229. [PubMed]
  • Mezzetti M, Ferraroni M, Decarli A, La Vecchia C, Benichou J. Software for attributable risk and confidence interval estimation in case-control studies. Comput Biomed Res. 1996 Feb;29(1):63–75. [PubMed]
  • MUSTACCHI P, SHIMKIN MB. Cancer of the bladder and infestation with Schistosoma hematobium. J Natl Cancer Inst. 1958 Apr;20(4):825–842. [PubMed]

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