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Protein Sci. Feb 1997; 6(2): 287–293.
PMCID: PMC2143655

A new method for analyzing protein sequence relationships based on Sammon maps.

Abstract

Recent advances in gene sequencing and rational drug design have re-emphasized the need for new methods for protein analysis, classification, and structure and function prediction. In this article, we introduce a new method for analyzing protein sequences based on Sammon's non-linear mapping algorithm. When applied to a family of homologous sequences, the method is able to capture the essential features of the similarity matrix, and provides a faithful representation of chemical or evolutionary distance in a simple and intuitive way. The merits of the new algorithm are demonstrated using examples from the protein kinase family.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
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