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J Exp Med. Nov 30, 1967; 126(6): 989–1004.
PMCID: PMC2138413

THE ROLE OF ANTI-GLOMERULAR BASEMENT MEMBRANE ANTIBODY IN THE PATHOGENESIS OF HUMAN GLOMERULONEPHRITIS

Abstract

These observations established the presence of anti-GBM antibodies in the sera and/or kidneys of six humans with glomerulonephritis. Further, it seems clear that these antibodies do combine with the host's glomeruli in vivo and with GBM antigen of several species in vitro. Transfer of acute glomerulonephritis to normal recipient monkeys was possible with serum or renal eluate IGG from the three patients with anti-GBM antibodies in whom sufficient material was available. Based on this transfer of nephritis and on the presence of these antibodies at the site of injury in the nephritic kidneys of both the patients and the recipient monkeys, it seems likely that they are at least a contributing, if not primary, cause of the glomerular injury. The frequency of anti-GBM antibodies in human nephritis is not certain, but on the basis of preliminary observations it would appear that they are present in all cases of Goodpasture's nephritis and somewhat less than half of the cases of subacute and chronic glomerulonephritis of adults. The nature and source of immunogen stimulating the production of anti-GBM antibodies is not known, but the presence of potentially nephritogenic GBM antigens in normal urine raises the question of possible autoimmunization. From a practical point of view, it appears that patients forming anti-GBM antibodies may not be good candidates for renal transplantation since they are likely to produce in the transplants the nephritic changes already suffered by their own kidneys.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • STEBLAY RW. Glomerulonephritis induced in sheep by injections of heterologous glomerular basement membrane and Freund's complete adjuvant. J Exp Med. 1962 Aug 1;116:253–272. [PMC free article] [PubMed]
  • Lerner RA, Dixon FJ. Transfer of ovine experimental allergic glomerulonephritis (EAG) with serum. J Exp Med. 1966 Sep 1;124(3):431–442. [PMC free article] [PubMed]
  • Unanue ER, Dixon FJ. Experimental allergic glomerulonephritis induced in the rabbit with heterologous renal antigens. J Exp Med. 1967 Jan 1;125(1):149–162. [PMC free article] [PubMed]
  • GERMUTH FG., Jr A comparative histologic and immunologic study in rabbits of induced hypersensitivity of the serum sickness type. J Exp Med. 1953 Feb 1;97(2):257–282. [PMC free article] [PubMed]
  • DIXON FJ, VAZQUEZ JJ, WEIGLE WO, COCHRANE CG. Pathogenesis of serum sickness. AMA Arch Pathol. 1958 Jan;65(1):18–28. [PubMed]
  • Edgington TS, Glassock RJ, Dixon FJ. Autologous immune-complex pathogenesis of experimental allergic glomerulonephritis. Science. 1967 Mar 17;155(3768):1432–1434. [PubMed]
  • Krishnan C, Kaplan MH. Immunopathologic studies of systemic lupus erythematosus. II. Antinuclear reaction of gamma-globulin eluted from homogenates and isolated glomeruli of kidneys from patients with lupus nephritis. J Clin Invest. 1967 Apr;46(4):569–579. [PMC free article] [PubMed]
  • Michael AF, Jr, Drummond KN, Good RA, Vernier RL. Acute poststreptococcal glomerulonephritis: immune deposit disease. J Clin Invest. 1966 Feb;45(2):237–248. [PMC free article] [PubMed]
  • Andres GA, Accinni L, Hsu KC, Zabriskie JB, Seegal BC. Electron microscopic studies of human glomerulonephritis with ferritin-conjugated antibody. Localization of antigen-antibody complexes in glomerular structures of patients with acute glomerulonephritis. J Exp Med. 1966 Feb 1;123(2):399–412. [PMC free article] [PubMed]
  • KRAKOWER CA, GREENSPON SA. Localization of the nephrotoxic antigen within the isolated renal glomerulus. AMA Arch Pathol. 1951 Jun;51(6):629–639. [PubMed]
  • McConahey PJ, Dixon FJ. A method of trace iodination of proteins for immunologic studies. Int Arch Allergy Appl Immunol. 1966;29(2):185–189. [PubMed]
  • Lerner RA, Dixon FJ. Spontaneous glomerulonephritis in sheep. Lab Invest. 1966 Jul;15(7):1279–1289. [PubMed]
  • CLARK HF, SHEPARD CC. A DIALYSIS TECHNIQUE FOR PREPARING FLUORESCENT ANTIBODY. Virology. 1963 Aug;20:642–644. [PubMed]
  • DUNCAN DA, DRUMMOND KN, MICHAEL AF, VERNIER RL. PULMONARY HEMORRHAGE AND GLOMERULONEPHRITIS. REPORT OS SIX CASES AND STUDY OF THE RENAL LESION BY THE FLUORESCENT ANTIBODY TECHNIQUE AND ELECTRON MICROSCOPY. Ann Intern Med. 1965 May;62:920–938. [PubMed]
  • Sturgill BC, Westervelt FB. Immunofluorescence studies in a case of Goodpasture's syndrome. JAMA. 1965 Nov 22;194(8):914–916. [PubMed]
  • MARKOWITZ AS, LANGE CF., Jr STREPTOCOCCAL RELATED GLOMERULONEPHRITIS. I. ISOLATION, IMMUNOCHEMISTRY AND COMPARATIVE CHEMISTRY OF SOLUBLE FRACTIONS FROM TYPE 12 NEPHRITOGENIC STREPTOCOCCI AND HUMAN GLOMERULI. J Immunol. 1964 Apr;92:565–575. [PubMed]
  • Feldman JD, Lee S. Renal homotransplantation in rats. I. Allogeneic recipients. J Exp Med. 1967 Nov 1;126(5):783–794. [PMC free article] [PubMed]

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