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J Exp Med. Feb 28, 1962; 115(3): 453–466.
PMCID: PMC2137509

THE CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES

Abstract

An in vitro technique is described for assessing the chemotactic activity of soluble substances on motile cells. Antibody-antigen mixtures when incubated (37°C) in medium containing fresh (i.e. non-inactivated) normal rabbit serum exert a strong chemotactic effect on rabbit polymorphonuclear leucocytes. Results are described which indicate that, when antibody-antigen complexes are incubated (37°C) in fresh serum, a heat-stable (56°C) substance (or substances) is produced which acts directly as a chemotactic stimulus on the polymorphs. This heat-stable chemotactic substance is not produced when antibody-antigen complexes are incubated in serum which has been heated at 56°C for 30 minutes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • HARRIS H. Role of chemotaxis in inflammation. Physiol Rev. 1954 Jul;34(3):529–562. [PubMed]
  • HIRSCH JG, CHURCH AB. Studies of phagocytosis of group A streptococci by polymorphonuclear leucocytes in vitro. J Exp Med. 1960 Mar 1;111:309–322. [PMC free article] [PubMed]
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