• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jexpmedHomeThe Rockefeller University PressEditorsContactInstructions for AuthorsThis issue
J Exp Med. Nov 1, 1943; 78(5): 407–423.
PMCID: PMC2135416

STUDIES OF ANTIGENIC DIFFERENCES AMONG STRAINS OF INFLUENZA A BY MEANS OF RED CELL AGGLUTINATION

Abstract

A study of cross inhibition tests among strains of influenza A virus and their antisera showed that the results obtained were subject to a certain amount of variation due to the red cells, the virus suspensions, and the ferret antisera employed. Methods have been demonstrated for handling the data obtained from such tests, so that these variables were corrected or avoided, making it possible to use the agglutination technique for antigenic comparisons. The antigenic pattern of eighteen strains of influenza A virus, obtained from the 1940–41 epidemic in the United States, has been compared by means of agglutination inhibition tests with ferret antisera. No significant antigenic differences were found among sixteen of these strains (all isolated from throat washings by the inoculation of chick embryos) although they were obtained from individuals in widely separated regions of the country. Two strains, from cases occurring early in the epidemic and isolated from throat washings by ferret and mouse passage, showed a slight but significant strain difference from the other strains and from each other. One of the 1940–41 strains on cross test resembled the PR8 strain more closely than any other stock strain tested.

Full Text

The Full Text of this article is available as a PDF (863K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Hirst GK. THE QUANTITATIVE DETERMINATION OF INFLUENZA VIRUS AND ANTIBODIES BY MEANS OF RED CELL AGGLUTINATION. J Exp Med. 1942 Jan 1;75(1):49–64. [PMC free article] [PubMed]
  • Hudson NP, Sigel MM, Markham FS. ANTIGENIC RELATIONSHIP OF BRITISH SWINE INFLUENZA STRAINS TO STANDARD HUMAN AND SWINE INFLUENZA VIRUSES : THE USE OF CHICKEN AND FERRET ANTISERA IN RED CELL AGGLUTINATION. J Exp Med. 1943 May 1;77(5):467–471. [PMC free article] [PubMed]
  • Francis T., Jr TRANSMISSION OF INFLUENZA BY A FILTERABLE VIRUS. Science. 1934 Nov 16;80(2081):457–459. [PubMed]
  • Chambers LA, Henle W. STUDIES ON THE NATURE OF THE VIRUS OF INFLUENZA : I. THE DISPERSION OF THE VIRUS OF INFLUENZA A IN TISSUE EMULSIONS AND IN EXTRA-EMBRYONIC FLUIDS OF THE CHICK. J Exp Med. 1943 Mar 1;77(3):251–264. [PMC free article] [PubMed]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...