Logo of jcellbiolHomeThe Rockefeller University PressEditorsContactInstructions for AuthorsThis issue
J Cell Biol. Dec 2, 1996; 135(6): 1609–1617.
PMCID: PMC2133950

Angiotensin II regulation of neuromodulation: downstream signaling mechanism from activation of mitogen-activated protein kinase

Abstract

Angiotensin II (Ang II) stimulates expression of tyrosine hydroxylase and norepinephrine transporter genes in brain neurons; however, the signal-transduction mechanism is not clearly defined. This study was conducted to determine the involvement of the mitogen-activated protein (MAP) kinase signaling pathway in Ang II stimulation of these genes. MAP kinase was localized in the perinuclear region of the neuronal soma. Ang II caused activation of MAP kinase and its subsequent translocation from the cytoplasmic to nuclear compartment, both effects being mediated by AT1 receptor subtype. Ang II also stimulated SRE- and AP1-binding activities and fos gene expression and its translocation in a MAP kinase-dependent process. These observations are the first demonstration of a downstream signaling pathway involving MAP kinase in Ang II-mediated neuromodulation in noradrenergic neurons.

Full Text

The Full Text of this article is available as a PDF (2.9M).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Beato M. Transcriptional control by nuclear receptors. FASEB J. 1991 Apr;5(7):2044–2051. [PubMed]
  • Bhat GJ, Thekkumkara TJ, Thomas WG, Conrad KM, Baker KM. Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein. J Biol Chem. 1994 Dec 16;269(50):31443–31449. [PubMed]
  • Goc A, Stachowiak MK. Bovine tyrosine hydroxylase gene-promoter regions involved in basal and angiotensin II-stimulated expression in nontransformed adrenal medullary cells. J Neurochem. 1994 Mar;62(3):834–843. [PubMed]
  • Gonzalez FA, Seth A, Raden DL, Bowman DS, Fay FS, Davis RJ. Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus. J Cell Biol. 1993 Sep;122(5):1089–1101. [PMC free article] [PubMed]
  • Hennekes H, Peter M, Weber K, Nigg EA. Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2. J Cell Biol. 1993 Mar;120(6):1293–1304. [PMC free article] [PubMed]
  • Khalil RA, Morgan KG. PKC-mediated redistribution of mitogen-activated protein kinase during smooth muscle cell activation. Am J Physiol. 1993 Aug;265(2 Pt 1):C406–C411. [PubMed]
  • Lamy F, Wilkin F, Baptist M, Posada J, Roger PP, Dumont JE. Phosphorylation of mitogen-activated protein kinases is involved in the epidermal growth factor and phorbol ester, but not in the thyrotropin/cAMP, thyroid mitogenic pathway. J Biol Chem. 1993 Apr 25;268(12):8398–8401. [PubMed]
  • Lu D, Raizada MK. Delivery of angiotensin II type 1 receptor antisense inhibits angiotensin action in neurons from hypertensive rat brain. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2914–2918. [PMC free article] [PubMed]
  • Lu D, Yu K, Raizada MK. Retrovirus-mediated transfer of an angiotensin type I receptor (AT1-R) antisense sequence decreases AT1-Rs and angiotensin II action in astroglial and neuronal cells in primary cultures from the brain. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1162–1166. [PMC free article] [PubMed]
  • Lu D, Yu K, Paddy MR, Rowland NE, Raizada MK. Regulation of norepinephrine transport system by angiotensin II in neuronal cultures of normotensive and spontaneously hypertensive rat brains. Endocrinology. 1996 Feb;137(2):763–772. [PubMed]
  • Mochly-Rosen D. Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science. 1995 Apr 14;268(5208):247–251. [PubMed]
  • Murray NR, Burns DJ, Fields AP. Presence of a beta II protein kinase C-selective nuclear membrane activation factor in human leukemia cells. J Biol Chem. 1994 Aug 19;269(33):21385–21390. [PubMed]
  • Puri PL, Avantaggiati ML, Burgio VL, Chirillo P, Collepardo D, Natoli G, Balsano C, Levrero M. Reactive oxygen intermediates mediate angiotensin II-induced c-Jun.c-Fos heterodimer DNA binding activity and proliferative hypertrophic responses in myogenic cells. J Biol Chem. 1995 Sep 22;270(38):22129–22134. [PubMed]
  • Raizada MK, Muther TF, Sumners C. Increased angiotensin II receptors in neuronal cultures from hypertensive rat brain. Am J Physiol. 1984 Nov;247(5 Pt 1):C364–C372. [PubMed]
  • Raizada MK, Lu D, Tang W, Kurian P, Sumners C. Increased angiotensin II type-1 receptor gene expression in neuronal cultures from spontaneously hypertensive rats. Endocrinology. 1993 Apr;132(4):1715–1722. [PubMed]
  • Raizada MK, Sumners C, Lu D. Angiotensin II type 1 receptor mRNA levels in the brains of normotensive and spontaneously hypertensive rats. J Neurochem. 1993 May;60(5):1949–1952. [PubMed]
  • Saavedra JM. Brain and pituitary angiotensin. Endocr Rev. 1992 May;13(2):329–380. [PubMed]
  • Sadoshima J, Qiu Z, Morgan JP, Izumo S. Angiotensin II and other hypertrophic stimuli mediated by G protein-coupled receptors activate tyrosine kinase, mitogen-activated protein kinase, and 90-kD S6 kinase in cardiac myocytes. The critical role of Ca(2+)-dependent signaling. Circ Res. 1995 Jan;76(1):1–15. [PubMed]
  • Summers RG, Musial CE, Cheng PC, Leith A, Marko M. The use of confocal microscopy and STERECON reconstructions in the analysis of sea urchin embryonic cell division. J Electron Microsc Tech. 1991 May;18(1):24–30. [PubMed]
  • Sumners C, Raizada MK. Angiotensin II stimulates norepinephrine uptake in hypothalamus-brain stem neuronal cultures. Am J Physiol. 1986 Feb;250(2 Pt 1):C236–C244. [PubMed]
  • Sumners C, Muther TF, Raizada MK. Altered norepinephrine uptake in neuronal cultures from spontaneously hypertensive rat brain. Am J Physiol. 1985 May;248(5 Pt 1):C488–C497. [PubMed]
  • Sumners C, Shalit SL, Kalberg CJ, Raizada MK. Norepinephrine metabolism in neuronal cultures is increased by angiotensin II. Am J Physiol. 1987 Jun;252(6 Pt 1):C650–C656. [PubMed]
  • Sumners C, Tang W, Zelezna B, Raizada MK. Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7567–7571. [PMC free article] [PubMed]
  • Sumners C, Raizada MK, Kang J, Lu D, Posner P. Receptor-mediated effects of angiotensin II on neurons. Front Neuroendocrinol. 1994 Sep;15(3):203–230. [PubMed]
  • Timmermans PB, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JA, Smith RD. Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev. 1993 Jun;45(2):205–251. [PubMed]
  • Ward Y, Gupta S, Jensen P, Wartmann M, Davis RJ, Kelly K. Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1. Nature. 1994 Feb 17;367(6464):651–654. [PubMed]
  • Wright JW, Harding JW. Brain angiotensin receptor subtypes in the control of physiological and behavioral responses. Neurosci Biobehav Rev. 1994 Spring;18(1):21–53. [PubMed]
  • Yamazaki T, Komuro I, Kudoh S, Zou Y, Shiojima I, Mizuno T, Takano H, Hiroi Y, Ueki K, Tobe K, et al. Angiotensin II partly mediates mechanical stress-induced cardiac hypertrophy. Circ Res. 1995 Aug;77(2):258–265. [PubMed]
  • Yang H, Lu D, Yu K, Raizada MK. Regulation of neuromodulatory actions of angiotensin II in the brain neurons by the Ras-dependent mitogen-activated protein kinase pathway. J Neurosci. 1996 Jul 1;16(13):4047–4058. [PubMed]
  • Yu K, Lu D, Rowland NE, Raizada MK. Angiotensin II regulation of tyrosine hydroxylase gene expression in the neuronal cultures of normotensive and spontaneously hypertensive rats. Endocrinology. 1996 Aug;137(8):3566–3576. [PubMed]
  • Zhao Y, Bjørbaek C, Weremowicz S, Morton CC, Moller DE. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation. Mol Cell Biol. 1995 Aug;15(8):4353–4363. [PMC free article] [PubMed]

Articles from The Journal of Cell Biology are provided here courtesy of The Rockefeller University Press

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...