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Figure 7

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cAMP specific-PDE activity is required for the chemotactic migration and invasion of MDA-MB-435 cells. The MDA/ β4 (5B3; squares) or mock transfectants (6D7; circles) were treated with varying concentrations (A) or 1 mM (B) IBMX for 30 min before their use in either an LPA chemotaxis assay (A) or a Matrigel chemoinvasion assay (B). Data shown represent mean values ± standard deviation of triplicate determinations.

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