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J Hyg (Lond). Oct 1975; 75(2): 215–218.
PMCID: PMC2130300

Experimental model of oral antityphoid vaccination with live streptomycin-dependent Salmonella typhimurium in C57BL/6 mice


The present experimental model offered the opportunity to study particular aspects concerning the avirulence stability of live streptomycin-dependent (Sm D) Salmonella vaccines, under conditions resembling human enteric fever. The results seem to indicate that, in practice, the risk of reversion to a virulent form during oral antityphoid vaccination with Sm D strains remains slight even after the interruption of concomitant streptomycin administration.

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Selected References

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  • BARON LS, FORMAL SB. Immunization studies with living vaccine of Salmonella typhimurium. Proc Soc Exp Biol Med. 1960 Aug-Sep;104:565–567. [PubMed]
  • Collins FM. Salmonellosis in orally infected specific pathogen-free C57B1 mice. Infect Immun. 1972 Feb;5(2):191–198. [PMC free article] [PubMed]
  • DuPont HL, Hornick RB, Snyder MJ, Libonati JP, Woodward TE. Immunity in typhoid fever: evaluation of live streptomycin-dependent vaccine. Antimicrob Agents Chemother (Bethesda) 1970;10:236–239. [PubMed]
  • Vladoianu IR, Dubini F, Bolloli A. Contribution to the study of live streptomycin-dependent Salmonella vaccines: the problem of reversion to a virulent form. J Hyg (Lond) 1975 Oct;75(2):203–214. [PMC free article] [PubMed]

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