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J Cell Biol. 1982 Nov 1; 95(2): 369–377.
PMCID: PMC2112946

Fibronectins: multifunctional modular glycoproteins

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Selected References

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  • Hynes RO. Cell surface proteins and malignant transformation. Biochim Biophys Acta. 1976 Apr 30;458(1):73–107. [PubMed]
  • Yamada KM, Olden K. Fibronectins--adhesive glycoproteins of cell surface and blood. Nature. 1978 Sep 21;275(5677):179–184. [PubMed]
  • Vaheri A, Mosher DF. High molecular weight, cell surface-associated glycoprotein (fibronectin) lost in malignant transformation. Biochim Biophys Acta. 1978 Sep 18;516(1):1–25. [PubMed]
  • Mosher DF. Fibronectin. Prog Hemost Thromb. 1980;5:111–151. [PubMed]
  • Saba TM, Jaffe E. Plasma fibronectin (opsonic glycoprotein): its synthesis by vascular endothelial cells and role in cardiopulmonary integrity after trauma as related to reticuloendothelial function. Am J Med. 1980 Apr;68(4):577–594. [PubMed]
  • Mosesson MW, Amrani DL. The structure and biologic activities of plasma fibronectin. Blood. 1980 Aug;56(2):145–158. [PubMed]
  • Pearlstein E, Gold LI, Garcia-Pardo A. Fibronectin: a review of its structure and biological activity. Mol Cell Biochem. 1980 Feb 8;29(2):103–128. [PubMed]
  • Voss B, Allam S, Rauterberg J, Ullrich K, Gieselmann V, von Figura K. Primary cultures of rat hepatocytes synthesize fibronectin. Biochem Biophys Res Commun. 1979 Oct 29;90(4):1348–1354. [PubMed]
  • Birdwell CR, Gospodarowicz D, Nicolson GL. Identification, localization, and role of fibronectin in cultured bovine endothelial cells. Proc Natl Acad Sci U S A. 1978 Jul;75(7):3273–3277. [PMC free article] [PubMed]
  • Macarak EJ, Kirby E, Kirk T, Kefalides NA. Synthesis of cold-insoluble globulin by cultured calf endothelial cells. Proc Natl Acad Sci U S A. 1978 Jun;75(6):2621–2625. [PMC free article] [PubMed]
  • Jaffe EA, Mosher DF. Synthesis of fibronectin by cultured human endothelial cells. J Exp Med. 1978 Jun 1;147(6):1779–1791. [PMC free article] [PubMed]
  • Alitalo K, Hovi T, Vaheri A. Fibronectin is produced by human macrophages. J Exp Med. 1980 Mar 1;151(3):602–613. [PMC free article] [PubMed]
  • Johansson S, Rubin K, Hök M, Ahlgren T, Seljelid R. In vitro biosynthesis of cold insoluble globulin (fibronectin) by mouse peritoneal macrophages. FEBS Lett. 1979 Sep 15;105(2):313–316. [PubMed]
  • van de Water L, 3rd, Schroeder S, Crenshaw EB, 3rd, Hynes RO. Phagocytosis of gelatin-latex particles by a murine macrophage line is dependent on fibronectin and heparin. J Cell Biol. 1981 Jul;90(1):32–39. [PMC free article] [PubMed]
  • Villiger B, Kelley DG, Engleman W, Kuhn C, 3rd, McDonald JA. Human alveolar macrophage fibronectin: synthesis, secretion, and ultrastructural localization during gelatin-coated latex particle binding. J Cell Biol. 1981 Sep;90(3):711–720. [PMC free article] [PubMed]
  • Alexander SS, Jr, Colonna G, Yamada KM, Pastan I, Edelhoch H. Molecular properties of a major cell surface protein from chick embryo fibroblasts. J Biol Chem. 1978 Aug 25;253(16):5820–5824. [PubMed]
  • Alexander SS, Jr, Colonna G, Edelhoch H. The structure and stability of human plasma cold-insoluble globulin. J Biol Chem. 1979 Mar 10;254(5):1501–1505. [PubMed]
  • Engel J, Odermatt E, Engel A, Madri JA, Furthmayr H, Rohde H, Timpl R. Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix. J Mol Biol. 1981 Jul 25;150(1):97–120. [PubMed]
  • Erickson HP, Carrell N, McDonagh J. Fibronectin molecule visualized in electron microscopy: a long, thin, flexible strand. J Cell Biol. 1981 Dec;91(3 Pt 1):673–678. [PMC free article] [PubMed]
  • Koteliansky VE, Glukhova MA, Bejanian MV, Smirnov VN, Filimonov VV, Zalite OM, Venyaminov SYu A study of the structure of fibronectin. Eur J Biochem. 1981 Oct;119(3):619–624. [PubMed]
  • Vaheri A, Kurkinen M, Lehto VP, Linder E, Timpl R. Codistribution of pericellular matrix proteins in cultured fibroblasts and loss in transformation: fibronectin and procollagen. Proc Natl Acad Sci U S A. 1978 Oct;75(10):4944–4948. [PMC free article] [PubMed]
  • Hedman K, Kurkinen M, Alitalo K, Vaheri A, Johansson S, Hök M. Isolation of the pericellular matrix of human fibroblast cultures. J Cell Biol. 1979 Apr;81(1):83–91. [PMC free article] [PubMed]
  • Perkins ME, Ji TH, Hynes RO. Cross-linking of fibronectin to sulfated proteoglycans at the cell surface. Cell. 1979 Apr;16(4):941–952. [PubMed]
  • Hedman K, Johansson S, Vartio T, Kjellén L, Vaheri A, Hök M. Structure of the pericellular matrix: association of heparan and chondroitin sulfates with fibronectin-procollagen fibers. Cell. 1982 Mar;28(3):663–671. [PubMed]
  • Grinnell F. Cellular adhesiveness and extracellular substrata. Int Rev Cytol. 1978;53:65–144. [PubMed]
  • Kleinman HK, Klebe RJ, Martin GR. Role of collagenous matrices in the adhesion and growth of cells. J Cell Biol. 1981 Mar;88(3):473–485. [PMC free article] [PubMed]
  • Grinnell F, Feld M, Minter D. Fibroblast adhesion to fibrinogen and fibrin substrata: requirement for cold-insoluble globulin (plasma fibronectin). Cell. 1980 Feb;19(2):517–525. [PubMed]
  • Yamada KM, Yamada SS, Pastan I. Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. Proc Natl Acad Sci U S A. 1976 Apr;73(4):1217–1221. [PMC free article] [PubMed]
  • Ali IU, Mautner V, Lanza R, Hynes RO. Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein. Cell. 1977 May;11(1):115–126. [PubMed]
  • Willingham MC, Yamada KM, Yamada SS, Pouysségur J, Pastan I. Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts. Cell. 1977 Mar;10(3):375–380. [PubMed]
  • Hynes RO, Destree AT. Relationships between fibronectin (LETS protein) and actin. Cell. 1978 Nov;15(3):875–886. [PubMed]
  • Heggeness MH, Ash JF, Singer SJ. Transmembrane linkage of fibronectin to intracellular actin-containing filaments in cultured human fibroblasts. Ann N Y Acad Sci. 1978 Jun 20;312:414–417. [PubMed]
  • Burridge K, Feramisco JR. Microinjection and localization of a 130K protein in living fibroblasts: a relationship to actin and fibronectin. Cell. 1980 Mar;19(3):587–595. [PubMed]
  • Singer II, Paradiso PR. A transmembrane relationship between fibronectin and vinculin (130 kd protein): serum modulation in normal and transformed hamster fibroblasts. Cell. 1981 May;24(2):481–492. [PubMed]
  • Hynes RO, Destree AT, Wagner DD. Relationships between microfilaments, cell-substratum adhesion, and fibronectin. Cold Spring Harb Symp Quant Biol. 1982;46(Pt 2):659–670. [PubMed]
  • Hynes R. Phosphorylation of vinculin by pp60src: what might it mean? Cell. 1982 Mar;28(3):437–438. [PubMed]
  • Olden K, Yamada KM. Mechanism of the decrease in the major cell surface protein of chick embryo fibroblasts after transformation. Cell. 1977 Aug;11(4):957–969. [PubMed]
  • Hynes RO, Ali IU, Destree AT, Mautner V, Perkins ME, Senger DR, Wagner DD, Smith KK. A large glycoprotein lost from the surfaces of transformed cells. Ann N Y Acad Sci. 1978 Jun 20;312:317–342. [PubMed]
  • Vaheri A, Ruoslahti E. Fibroblast surface antigen produced but not retained by virus-transformed human cells. J Exp Med. 1975 Aug 1;142(2):530–535. [PMC free article] [PubMed]
  • Hayman EG, Engvall E, Ruoslahti E. Concomitant loss of cell surface fibronectin and laminin from transformed rat kidney cells. J Cell Biol. 1981 Feb;88(2):352–357. [PMC free article] [PubMed]
  • Wagner DD, Ivatt R, Destree AT, Hynes RO. Similarities and differences between the fibronectins of normal and transformed hamster cells. J Biol Chem. 1981 Nov 25;256(22):11708–11715. [PubMed]
  • Chen LB, Gallimore PH, McDougall JK. Correlation between tumor induction and the large external transformation sensitive protein on the cell surface. Proc Natl Acad Sci U S A. 1976 Oct;73(10):3570–3574. [PMC free article] [PubMed]
  • Gallimore PH, McDougall JK, Chen LB. In vitro traits of adenovirus-transformed cell lines and their relevance to tumorigenicity in nude mice. Cell. 1977 Apr;10(4):669–678. [PubMed]
  • Kahn P, Shin SI. Cellular tumorigenicity in nude mice. Test of associations among loss of cell-surface fibronectin, anchorage independence, and tumor-forming ability. J Cell Biol. 1979 Jul;82(1):1–16. [PMC free article] [PubMed]
  • Der CJ, Stanbridge EJ. Lack of correlation between the decreased expression of cell surface LETS protein and tumorigenicity in human cell hybrids. Cell. 1978 Dec;15(4):1241–1251. [PubMed]
  • Gallimore PH, McDougall JK, Chen LB. Malignant behaviour of three adenovirus-2-transformed brain cell lines and their methyl cellulose-selected sub-clones. Int J Cancer. 1979 Oct 15;24(4):477–484. [PubMed]
  • Smith HS, Riggs JL, Mosesson MW. Production of fibronectin by human epithelial cells in culture. Cancer Res. 1979 Oct;39(10):4138–4144. [PubMed]
  • Ali IU, Hynes RO. Effects of LETS glycoprotein on cell motility. Cell. 1978 Jun;14(2):439–446. [PubMed]
  • Yamada KM, Olden K, Pastan I. Transformation-sensitive cell surface protein: isolation, characterization, and role in cellular morphology and adhesion. Ann N Y Acad Sci. 1978 Jun 20;312:256–277. [PubMed]
  • Gauss-Müller V, Kleinman HK, Martin GR, Schiffmann E. Role of attachment factors and attractants in fibroblast chemotaxis. J Lab Clin Med. 1980 Dec;96(6):1071–1080. [PubMed]
  • Greenberg JH, Seppä S, Seppä H, Tyl Hewitt A. Role of collagen and fibronectin in neural crest cell adhesion and migration. Dev Biol. 1981 Oct 30;87(2):259–266. [PubMed]
  • Critchley DR, England MA, Wakely J, Hynes RO. Distribution of fibronectin in the ectoderm of gastrulating chick embryos. Nature. 1979 Aug 9;280(5722):498–500. [PubMed]
  • Newgreen D, Thiery JP. Fibronectin in early avian embryos: synthesis and distribution along the migration pathways of neural crest cells. Cell Tissue Res. 1980;211(2):269–291. [PubMed]
  • Mayer BW, Jr, Hay ED, Hynes RO. Immunocytochemical localization of fibronectin in embryonic chick trunk and area vasculosa. Dev Biol. 1981 Mar;82(2):267–286. [PubMed]
  • Heasman J, Hynes RO, Swan AP, Thomas V, Wylie CC. Primordial germ cells of Xenopus embryos: the role of fibronectin in their adhesion during migration. Cell. 1981 Dec;27(3 Pt 2):437–447. [PubMed]
  • Spiegel E, Burger M, Spiegel M. Fibronectin in the developing sea urchin embryo. J Cell Biol. 1980 Oct;87(1):309–313. [PMC free article] [PubMed]
  • Katow H, Yamada KM, Solursh M. Occurrence of fibronectin on the primary mesenchyme cell surface during migration in the sea urchin embryo. Differentiation. 1982;22(2):120–124. [PubMed]
  • Akers RM, Mosher DF, Lilien JE. Promotion of retinal neurite outgrowth by substratum-bound fibronectin. Dev Biol. 1981 Aug;86(1):179–188. [PubMed]
  • Kuusela P. Fibronectin binds to Staphylococcus aureus. Nature. 1978 Dec 14;276(5689):718–720. [PubMed]
  • Mosher DF, Proctor RA. Binding and factor XIIIa-mediated cross-linking of a 27-kilodalton fragment of fibronectin to Staphylococcus aureus. Science. 1980 Aug 22;209(4459):927–929. [PubMed]
  • Menzel EJ, Smolen JS, Liotta L, Reid KB. Interaction of fibronectin with C1q and its collagen-like fragment (CLF). FEBS Lett. 1981 Jun 29;129(1):188–192. [PubMed]
  • Pearlstein E, Sorvillo J, Gigli I. The interaction of human plasma fibronectin with a subunit of the first component of complement, C1q. J Immunol. 1982 May;128(5):2036–2039. [PubMed]
  • Bing DH, Almeda S, Isliker H, Lahav J, Hynes RO. Fibronectin binds to the C1q component of complement. Proc Natl Acad Sci U S A. 1982 Jul;79(13):4198–4201. [PMC free article] [PubMed]
  • Molnar J, Gelder FB, Lai MZ, Siefring GE, Jr, Credo RB, Lorand L. Purification of opsonically active human and rat cold-insoluble globulin (plasma fibronectin). Biochemistry. 1979 Sep 4;18(18):3909–3916. [PubMed]
  • Gudewicz PW, Molnar J, Lai MZ, Beezhold DW, Siefring GE, Jr, Credo RB, Lorand L. Fibronectin-mediated uptake of gelatin-coated latex particles by peritoneal macrophages. J Cell Biol. 1980 Nov;87(2 Pt 1):427–433. [PMC free article] [PubMed]
  • Marquette D, Molnar J, Yamada K, Schlesinger D, Darby S, Van Alten P. Phagocytosis-promoting activity of avian plasma and fibroblastic cell surface fibronectins. Mol Cell Biochem. 1981 May 26;36(3):147–155. [PubMed]
  • Mosher DF, Schad PE. Cross-linking of fibronectin to collagen by blood coagulation Factor XIIIa. J Clin Invest. 1979 Sep;64(3):781–787. [PMC free article] [PubMed]
  • Plow EF, Birdwell C, Ginsberg MH. Identification and quantitation of platelet-associated fibronectin antigen. J Clin Invest. 1979 Mar;63(3):540–543. [PMC free article] [PubMed]
  • Zucker MB, Mosesson MW, Broekman MJ, Kaplan KL. Release of platelet fibronectin (cold-insoluble globulin) from alpha granules induced by thrombin or collagen; lack of requirement for plasma fibronectin in ADP-induced platelet aggregation. Blood. 1979 Jul;54(1):8–12. [PubMed]
  • Ginsberg MH, Painter RG, Forsyth J, Birdwell C, Plow EF. Thrombin increases expression of fibronectin antigen on the platelet surface. Proc Natl Acad Sci U S A. 1980 Feb;77(2):1049–1053. [PMC free article] [PubMed]
  • Lahav J, Hynes RO. Involvement of fibronectin, Von Willebrand factor, and fibrinogen in platelet interaction with solid substrata. J Supramol Struct Cell Biochem. 1981;17(4):299–311. [PubMed]
  • Plow EF, Ginsberg MH. Specific and saturable binding of plasma fibronectin to thrombin-stimulated human platelets. J Biol Chem. 1981 Sep 25;256(18):9477–9482. [PubMed]
  • Hoyer LW. The factor VIII complex: structure and function. Blood. 1981 Jul;58(1):1–13. [PubMed]
  • Sakariassen KS, Bolhuis PA, Sixma JJ. Human blood platelet adhesion to artery subendothelium is mediated by factor VIII-Von Willebrand factor bound to the subendothelium. Nature. 1979 Jun 14;279(5714):636–638. [PubMed]
  • Baenziger NL, Brodie GN, Majerus PW. Isolation and properties of a thrombin-sensitive protein of human platelets. J Biol Chem. 1972 May 10;247(9):2723–2731. [PubMed]
  • Lawler JW, Slayter HS, Coligan JE. Isolation and characterization of a high molecular weight glycoprotein from human blood platelets. J Biol Chem. 1978 Dec 10;253(23):8609–8616. [PubMed]
  • Grinnell F, Feld M, Snell W. The influence of cold insoluble globulin on platelet morphological response to substrata. Cell Biol Int Rep. 1979 Oct;3(7):585–592. [PubMed]
  • Gartner TK, Williams DC, Minion FC, Phillips DR. Thrombin-induced platelet aggregation is mediated by a platelet plasma membrane-bound lectin. Science. 1978 Jun 16;200(4347):1281–1283. [PubMed]
  • Jaffe EA, Leung LL, Nachman RL, Levin RI, Mosher DF. Thrombospondin is the endogenous lectin of human platelets. Nature. 1982 Jan 21;295(5846):246–248. [PubMed]
  • Podleski TR, Greenberg I, Schlessinger J, Yamada KM. Fibronectin delays the fusion of L6 myoblasts. Exp Cell Res. 1979 Sep;122(2):317–326. [PubMed]
  • West CM, Lanza R, Rosenbloom J, Lowe M, Holtzer H, Avdalovic N. Fibronectin alters the phenotypic properties of cultured chick embryo chondroblasts. Cell. 1979 Jul;17(3):491–501. [PubMed]
  • Pennypacker JP, Hassell JR, Yamada KM, Pratt RM. The influence of an adhesive cell surface protein on chondrogenic expression in vitro. Exp Cell Res. 1979 Jul;121(2):411–415. [PubMed]
  • Dessau W, Sasse J, Timpl R, Jilek F, von der Mark K. Synthesis and extracellular deposition of fibronectin in chondrocyte cultures. Response to the removal of extracellular cartilage matrix. J Cell Biol. 1978 Nov;79(2 Pt 1):342–355. [PMC free article] [PubMed]
  • Silver MH, Foidart JM, Pratt RM. Distribution of fibronectin and collagen during mouse limb and palate development. Differentiation. 1981;18(3):141–149. [PubMed]
  • Chiquet M, Eppenberger HM, Turner DC. Muscle morphogenesis: Evidence for an organizing function of exogenous fibronectin. Dev Biol. 1981 Dec;88(2):220–235. [PubMed]
  • Tomasek JJ, Mazurkiewicz JE, Newman SA. Nonuniform distribution of fibronectin during avian limb development. Dev Biol. 1982 Mar;90(1):118–126. [PubMed]
  • Sieber-Blum M, Sieber F, Yamada KM. Cellular fibronectin promotes adrenergic differentiation of quail neural crest cells in vitro. Exp Cell Res. 1981 Jun;133(2):285–295. [PubMed]
  • Loring J, Glimelius B, Weston JA. Extracellular matrix materials influence quail neural crest cell differentiation in vitro. Dev Biol. 1982 Mar;90(1):165–174. [PubMed]
  • Yamada KM, Schlesinger DH, Kennedy DW, Pastan I. Characterization of a major fibroblast cell surface glycoprotein. Biochemistry. 1977 Dec 13;16(25):5552–5559. [PubMed]
  • Ruoslahti E, Hayman EG, Kuusela P, Shively JE, Engvall E. Isolation of a tryptic fragment containing the collagen-binding site of plasma fibronectin. J Biol Chem. 1979 Jul 10;254(13):6054–6059. [PubMed]
  • Balian G, Click EM, Crouch E, Davidson JM, Bornstein P. Isolation of a collagen-binding fragment from fibronectin and cold-insoluble globulin. J Biol Chem. 1979 Mar 10;254(5):1429–1432. [PubMed]
  • Hahn LH, Yamada KM. Identification and isolation of a collagen-binding fragment of the adhesive glycoprotein fibronectin. Proc Natl Acad Sci U S A. 1979 Mar;76(3):1160–1163. [PMC free article] [PubMed]
  • Hahn LH, Yamada KM. Isolation and biological characterization of active fragments of the adhesive glycoprotein fibronectin. Cell. 1979 Dec;18(4):1043–1051. [PubMed]
  • Gold LI, Garcia-Pardo A, Frangione B, Franklin EC, Pearlstein E. Subtilisin and cyanogen bromide cleavage products of fibronectin that retain gelatin-binding activity. Proc Natl Acad Sci U S A. 1979 Oct;76(10):4803–4807. [PMC free article] [PubMed]
  • Furie MB, Rifkin DB. Proteolytically derived fragments of human plasma fibronectin and their localization within the intact molecule. J Biol Chem. 1980 Apr 10;255(7):3134–3140. [PubMed]
  • Mosher DF, Schad PE, Vann JM. Cross-linking of collagen and fibronectin by factor XIIIa. Localization of participating glutaminyl residues to a tryptic fragment of fibronectin. J Biol Chem. 1980 Feb 10;255(3):1181–1188. [PubMed]
  • McDonald JA, Kelley DG. Degradation of fibronectin by human leukocyte elastase. Release of biologically active fragments. J Biol Chem. 1980 Sep 25;255(18):8848–8858. [PubMed]
  • Yamada KM, Kennedy DW, Kimata K, Pratt RM. Characterization of fibronectin interactions with glycosaminoglycans and identification of active proteolytic fragments. J Biol Chem. 1980 Jul 10;255(13):6055–6063. [PubMed]
  • Wagner DD, Hynes RO. Topological arrangement of the major structural features of fibronectin. J Biol Chem. 1980 May 10;255(9):4304–4312. [PubMed]
  • Balian G, Click EM, Bornstein P. Location of a collagen-binding domain in fibronectin. J Biol Chem. 1980 Apr 25;255(8):3234–3236. [PubMed]
  • Furie MB, Frey AB, Rifkin DB. Location of a gelatin-binding region of human plasma fibronectin. J Biol Chem. 1980 May 25;255(10):4391–4394. [PubMed]
  • Sekiguchi K, Hakomori S. Functional domain structure of fibronectin. Proc Natl Acad Sci U S A. 1980 May;77(5):2661–2665. [PMC free article] [PubMed]
  • Hayashi M, Schlesinger DH, Kennedy DW, Yamada KM. Isolation and characterization of a heparin-binding domain of cellular fibronectin. J Biol Chem. 1980 Nov 10;255(21):10017–10020. [PubMed]
  • Keski-Oja J, Yamada KM. Isolation of an actin-binding fragment of fibronectin. Biochem J. 1981 Feb 1;193(2):615–620. [PMC free article] [PubMed]
  • Sekiguchi K, Fukuda M, Hakomori S. Domain structure of hamster plasma fibronectin. Isolation and characterization of four functionally distinct domains and their unequal distribution between two subunit polypeptides. J Biol Chem. 1981 Jun 25;256(12):6452–6462. [PubMed]
  • Ruoslahti E, Hayman EG, Engvall E, Cothran WC, Butler WT. Alignment of biologically active domains in the fibronectin molecule. J Biol Chem. 1981 Jul 25;256(14):7277–7281. [PubMed]
  • Richter H, Seidl M, Hörmann H. Location of heparin-binding sites of fibronectin. Detection of a hitherto unrecognized transamidase sensitive site. Hoppe Seylers Z Physiol Chem. 1981 Apr;362(4):399–408. [PubMed]
  • Hayashi M, Yamada KM. Differences in domain structures between plasma and cellular fibronectins. J Biol Chem. 1981 Nov 10;256(21):11292–11300. [PubMed]
  • Pierschbacher MD, Hayman EG, Ruoslahti E. Location of the cell-attachment site in fibronectin with monoclonal antibodies and proteolytic fragments of the molecule. Cell. 1981 Oct;26(2 Pt 2):259–267. [PubMed]
  • Grinnell F, Billingham RE, Burgess L. Distribution of fibronectin during wound healing in vivo. J Invest Dermatol. 1981 Mar;76(3):181–189. [PubMed]
  • Hörmann H, Seidl M. Affinity chromatography on immobilized fibrin monomer, III. The fibrin affinity center of fibronectin. Hoppe Seylers Z Physiol Chem. 1980 Sep;361(9):1449–1452. [PubMed]
  • Jilek F, Hörmann H. Cold-insoluble globulin, II[1,2]. Cyanogen bromide and plasminolysis fragments containing a label introduced by transamidation. Hoppe Seylers Z Physiol Chem. 1977 Sep;358(9):1165–1168. [PubMed]
  • Zardi L, Siri A, Carnemolla B, Santi L, Gardner WD, Hoch SO. Fibronectin: a chromatin-associated protein? Cell. 1979 Nov;18(3):649–657. [PubMed]
  • Hayashi M, Yamada KM. Divalent cation modulation of fibronectin binding to heparin and to DNA. J Biol Chem. 1982 May 10;257(9):5263–5267. [PubMed]
  • Stathakis NE, Mosesson MW. Interactions among heparin, cold-insoluble globulin, and fibrinogen in formation of the heparin-precipitable fraction of plasma. J Clin Invest. 1977 Oct;60(4):855–865. [PMC free article] [PubMed]
  • Jilek F, Hörmann H. Fibronectin (cold-insoluble globulin), VI. Influence of heparin and hyaluronic acid on the binding of native collagen. Hoppe Seylers Z Physiol Chem. 1979 Apr;360(4):597–603. [PubMed]
  • Hörmann H, Jelinić V. Regulation by heparin and hyaluronic acid of the fibronectin-dependent association of collagen, Type III, with macrophages. Hoppe Seylers Z Physiol Chem. 1981 Jan;362(1):87–94. [PubMed]
  • Ruoslahti E, Engvall E. Complexing of fibronectin glycosaminoglycans and collagen. Biochim Biophys Acta. 1980 Aug 13;631(2):350–358. [PubMed]
  • Johansson S, Hök M. Heparin enhances the rate of binding of fibronectin to collagen. Biochem J. 1980 May 1;187(2):521–524. [PMC free article] [PubMed]
  • Laterra J, Culp LA. Differences in hyaluronate binding to plasma and cell surface fibronectins. Requirement for aggregation. J Biol Chem. 1982 Jan 25;257(2):719–726. [PubMed]
  • Jilek F, Hörmann H. Cold-insoluble globulin, II. Plasminolysis of cold-insoluble globulin. Hoppe Seylers Z Physiol Chem. 1977 Jan;358(1):133–136. [PubMed]
  • Chen AB, Amrani DL, Mosesson MW. Heterogeneity of the cold-insoluble globulin of human plasma (CIg), a circulating cell surface protein. Biochim Biophys Acta. 1977 Aug 23;493(2):310–322. [PubMed]
  • Fukuda M, Hakomori S. Proteolytic and chemical fragmentation of galactoprotein a, a major transformation-sensitive glycoprotein released from hamster embryo fibroblasts. J Biol Chem. 1979 Jun 25;254(12):5442–5450. [PubMed]
  • Smith DE, Mosher DF, Johnson RB, Furcht LT. Immunological identification of two sulfhydryl-containing fragments of human plasma fibronectin. J Biol Chem. 1982 May 25;257(10):5831–5838. [PubMed]
  • Postlethwaite AE, Keski-Oja J, Balian G, Kang AH. Induction of fibroblast chemotaxis by fibronectin. Localization of the chemotactic region to a 140,000-molecular weight non-gelatin-binding fragment. J Exp Med. 1981 Feb 1;153(2):494–499. [PMC free article] [PubMed]
  • Seppä HE, Yamada KM, Seppä ST, Silver MH, Kleinman HK, Schiffmann E. The cell binding fragment of fibronectin is chemotactic for fibroblasts. Cell Biol Int Rep. 1981 Aug;5(8):813–819. [PubMed]
  • Duksin D, Bornstein P. Changes in surface properties of normal and transformed cells caused by tunicamycin, an inhibitor of protein glycosylation. Proc Natl Acad Sci U S A. 1977 Aug;74(8):3433–3437. [PMC free article] [PubMed]
  • Olden K, Pratt RM, Yamada KM. Role of carbohydrate in biological function of the adhesive glycoprotein fibronectin. Proc Natl Acad Sci U S A. 1979 Jul;76(7):3343–3347. [PMC free article] [PubMed]
  • Bernard BA, Yamada KM, Olden K. Carbohydrates selectively protect a specific domain of fibronectin against proteases. J Biol Chem. 1982 Jul 25;257(14):8549–8554. [PubMed]
  • Pena SD, Hughes RC. Fibroblast to substratum contacts mediated by the different forms of fibronectin. Cell Biol Int Rep. 1978 Jul;2(4):339–344. [PubMed]
  • Yamada KM, Kennedy DW. Fibroblast cellular and plasma fibronectins are similar but not identical. J Cell Biol. 1979 Feb;80(2):492–498. [PMC free article] [PubMed]
  • Hynes RO, Destree A. Extensive disulfide bonding at the mammalian cell surface. Proc Natl Acad Sci U S A. 1977 Jul;74(7):2855–2859. [PMC free article] [PubMed]
  • Keski-Oja J, Mosher DF, Vaheri A. Dimeric character of fibronectin, a major cell surface-associated glycoprotein. Biochem Biophys Res Commun. 1977 Jan 24;74(2):699–706. [PubMed]
  • McConnell MR, Blumberg PM, Rossow PW. Dimeric and high molecular weight forms of the large external transformation-sensitive protein on the surface of chick embryo fibroblasts. J Biol Chem. 1978 Oct 25;253(20):7522–7530. [PubMed]
  • Atherton BT, Hynes RO. A difference between plasma and cellular fibronectins located with monoclonal antibodies. Cell. 1981 Jul;25(1):133–141. [PubMed]
  • McDonald JA, Broekelmann TJ, Kelley DG, Villiger B. Gelatin-binding domain-specific anti-human plasma fibronectin Fab' inhibits fibronectin-mediated gelatin binding but not cell spreading. J Biol Chem. 1981 Jun 10;256(11):5583–5587. [PubMed]
  • McDonald JA, Kelley DG, Broekelmann TJ. Role of fibronectin in collagen deposition: Fab' to the gelatin-binding domain of fibronectin inhibits both fibronectin and collagen organization in fibroblast extracellular matrix. J Cell Biol. 1982 Feb;92(2):485–492. [PMC free article] [PubMed]
  • Kleinman HK, Martin GR, Fishman PH. Ganglioside inhibition of fibronectin-mediated cell adhesion to collagen. Proc Natl Acad Sci U S A. 1979 Jul;76(7):3367–3371. [PMC free article] [PubMed]
  • Yamada KM, Kennedy DW, Grotendorst GR, Momoi T. Glycolipids: receptors for fibronectin? J Cell Physiol. 1981 Nov;109(2):343–351. [PubMed]
  • Emmerling MR, Johnson CD, Mosher DF, Lipton BH, Lilien JE. Cross-linking and binding of fibronectin with asymmetric acetylcholinesterase. Biochemistry. 1981 May 26;20(11):3242–3247. [PubMed]

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