• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jbacterPermissionsJournals.ASM.orgJournalJB ArticleJournal InfoAuthorsReviewers
J Bacteriol. Jan 1988; 170(1): 482–484.
PMCID: PMC210674

Synthesis of bacilysin by Bacillus subtilis branches from prephenate of the aromatic amino acid pathway.


Previously characterized mutants of Bacillus subtilis 168 were analyzed for the accumulation of the antibiotic bacilysin in culture broths and for the presence of bacilysin synthetase in cell extracts. All aro mutants tested were deficient in bacilysin biosynthesis but had synthetase activity. Mutants with lesions in tyrA and pheA produced normal levels of bacilysin, suggesting that prephenate is the primary metabolic precursor of bacilysin.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (489K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Dedonder RA, Lepesant JA, Lepesant-Kejzlarová J, Billault A, Steinmetz M, Kunst F. Construction of a kit of reference strains for rapid genetic mapping in Bacillus subtilis 168. Appl Environ Microbiol. 1977 Apr;33(4):989–993. [PMC free article] [PubMed]
  • Hoch JA, Nester EW. Gene-enzyme relationships of aromatic acid biosynthesis in Bacillus subtilis. J Bacteriol. 1973 Oct;116(1):59–66. [PMC free article] [PubMed]
  • Kenig M, Abraham EP. Antimicrobial activities and antagonists of bacilysin and anticapsin. J Gen Microbiol. 1976 May;94(1):37–45. [PubMed]
  • Nester EW, Lorence JH, Nasser DS. An enzyme aggregate involved in the biosynthesis of aromatic amino acids in Bacillus subtilis. Its possible function in feedback regulation. Biochemistry. 1967 May;6(5):1553–1563. [PubMed]
  • Perry D, Abraham EP. Transport and metabolism of bacilysin and other peptides by suspensions of Staphylococcus aureus. J Gen Microbiol. 1979 Nov;115(1):213–221. [PubMed]
  • Roscoe J, Abraham EP. Experiments relating to the biosynthesis of bacilysin. Biochem J. 1966 Jun;99(3):793–800. [PMC free article] [PubMed]
  • Shah R, Neuss N, Gorman M, Boeck LD. Isolation, purification, and characterization of anticapsin. J Antibiot (Tokyo) 1970 Dec;23(12):613–619. [PubMed]
  • Walker JE. Antibiotic production and sporulation in Bacillus subtilis. Biochem J. 1971 Feb;121(3):571–573. [PMC free article] [PubMed]
  • Walker JE, Abraham EP. The structure of bacilysin and other products of Bacillus subtilis. Biochem J. 1970 Jul;118(4):563–570. [PMC free article] [PubMed]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • Compound
    PubChem Compound links
  • MedGen
    Related information in MedGen
  • Pathways + GO
    Pathways + GO
    Pathways, annotations and biological systems (BioSystems) that cite the current article.
  • PubMed
    PubMed citations for these articles
  • Substance
    PubChem Substance links
  • Taxonomy
    Related taxonomy entry
  • Taxonomy Tree
    Taxonomy Tree

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...