• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of brjcancerBJC HomepageBJC Advance online publicationBJC Current IssueSubmitting an article to BJCWeb feeds
Br J Cancer. Sep 1996; 74(5): 717–721.
PMCID: PMC2074714

Do heat shock proteins have a role in breast cancer?

Abstract

It is clear therefore that hsps are overexpressed in patients with malignant tumours compared with healthy controls and this overexpression does show some correlation with disease features. Furthermore, expression of hsps has been reported on the cell surface of tumour cell lines. This could be associated with the immune response which has been reported with hsp90 and which also correlates with some disease features. It now appears that hsps may be involved in the presentation of tumour antigens leading to the possibility of hsps being used as a means of therapy. Hsp65 expression has not been investigated in patients with breast cancer. However, transfection of bacterial hsp65 into a tumour cell line resulted in the hsp65-expressing tumour cells losing their tumorigenicity in mice (Lukacs et al., 1993). Thus, hsps and the immune response to them are of interest as diagnostic and prognostic tools as well as a novel form of immunotherapy.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1013K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Ciocca DR, Dufau ML. Estrogen-dependent Leydig cell protein recognized by monoclonal antibody to MCF-7 cell line. Science. 1984 Oct 26;226(4673):445–446. [PubMed]
  • Ciocca DR, Luque EH. Immunological evidence for the identity between the hsp27 estrogen-regulated heat shock protein and the p29 estrogen receptor-associated protein in breast and endometrial cancer. Breast Cancer Res Treat. 1991 Dec;20(1):33–42. [PubMed]
  • Ciocca DR, Adams DJ, Bjercke RJ, Edwards DP, McGuire WL. Immunohistochemical detection of an estrogen-regulated protein by monoclonal antibodies. Cancer Res. 1982 Oct;42(10):4256–4258. [PubMed]
  • Ciocca DR, Fuqua SA, Lock-Lim S, Toft DO, Welch WJ, McGuire WL. Response of human breast cancer cells to heat shock and chemotherapeutic drugs. Cancer Res. 1992 Jul 1;52(13):3648–3654. [PubMed]
  • Ciocca DR, Oesterreich S, Chamness GC, McGuire WL, Fuqua SA. Biological and clinical implications of heat shock protein 27,000 (Hsp27): a review. J Natl Cancer Inst. 1993 Oct 6;85(19):1558–1570. [PubMed]
  • Ciocca DR, Clark GM, Tandon AK, Fuqua SA, Welch WJ, McGuire WL. Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications. J Natl Cancer Inst. 1993 Apr 7;85(7):570–574. [PubMed]
  • Coffer AI, Lewis KM, Brockas AJ, King RJ. Monoclonal antibodies against a component related to soluble estrogen receptor. Cancer Res. 1985 Aug;45(8):3686–3693. [PubMed]
  • Conroy SE, Gibson SL, Brunström G, Isenberg D, Luqmani Y, Latchman DS. Autoantibodies to 90 kD heat-shock protein in sera of breast cancer patients. Lancet. 1995 Jan 14;345(8942):126–126. [PubMed]
  • Crawford LV, Pim DC, Bulbrook RD. Detection of antibodies against the cellular protein p53 in sera from patients with breast cancer. Int J Cancer. 1982 Oct 15;30(4):403–408. [PubMed]
  • Creighton TE. Protein folding. Biochem J. 1990 Aug 15;270(1):1–16. [PMC free article] [PubMed]
  • Davidoff AM, Iglehart JD, Marks JR. Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3439–3442. [PMC free article] [PubMed]
  • Edwards DP, Adams DJ, McGuire WL. Estradiol stimulates synthesis of a major intracellular protein in a human breast cancer cell line (MCF-7). Breast Cancer Res Treat. 1981;1(3):209–223. [PubMed]
  • Ferrarini M, Heltai S, Zocchi MR, Rugarli C. Unusual expression and localization of heat-shock proteins in human tumor cells. Int J Cancer. 1992 Jun 19;51(4):613–619. [PubMed]
  • Fuqua SA, Blum-Salingaros M, McGuire WL. Induction of the estrogen-regulated "24K" protein by heat shock. Cancer Res. 1989 Aug 1;49(15):4126–4129. [PubMed]
  • Huot J, Roy G, Lambert H, Chrétien P, Landry J. Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27,000 heat shock protein. Cancer Res. 1991 Oct 1;51(19):5245–5252. [PubMed]
  • Iwaya K, Tsuda H, Fujita S, Suzuki M, Hirohashi S. Natural state of mutant p53 protein and heat shock protein 70 in breast cancer tissues. Lab Invest. 1995 Jun;72(6):707–714. [PubMed]
  • Jameel A, Skilton RA, Campbell TA, Chander SK, Coombes RC, Luqmani YA. Clinical and biological significance of HSP89 alpha in human breast cancer. Int J Cancer. 1992 Feb 1;50(3):409–415. [PubMed]
  • Konno A, Sato N, Yagihashi A, Torigoe T, Cho JM, Torimoto K, Hara I, Wada Y, Okubo M, Takahashi N, et al. Heat- or stress-inducible transformation-associated cell surface antigen on the activated H-ras oncogene-transfected rat fibroblast. Cancer Res. 1989 Dec 1;49(23):6578–6582. [PubMed]
  • Latchman DS. Heat shock proteins and human disease. J R Coll Physicians Lond. 1991 Oct;25(4):295–299. [PubMed]
  • Lindquist S. The heat-shock response. Annu Rev Biochem. 1986;55:1151–1191. [PubMed]
  • Lindquist S, Craig EA. The heat-shock proteins. Annu Rev Genet. 1988;22:631–677. [PubMed]
  • Love S, King RJ. A 27 kDa heat shock protein that has anomalous prognostic powers in early and advanced breast cancer. Br J Cancer. 1994 Apr;69(4):743–748. [PMC free article] [PubMed]
  • Lukacs KV, Lowrie DB, Stokes RW, Colston MJ. Tumor cells transfected with a bacterial heat-shock gene lose tumorigenicity and induce protection against tumors. J Exp Med. 1993 Jul 1;178(1):343–348. [PMC free article] [PubMed]
  • Mileo AM, Fanuele M, Battaglia F, Scambia G, Benedetti-Panici P, Mancuso S, Ferrini U. Selective over-expression of mRNA coding for 90 KDa stress-protein in human ovarian cancer. Anticancer Res. 1990 Jul-Aug;10(4):903–906. [PubMed]
  • Miron T, Vancompernolle K, Vandekerckhove J, Wilchek M, Geiger B. A 25-kD inhibitor of actin polymerization is a low molecular mass heat shock protein. J Cell Biol. 1991 Jul;114(2):255–261. [PMC free article] [PubMed]
  • Multhoff G, Botzler C, Wiesnet M, Müller E, Meier T, Wilmanns W, Issels RD. A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. Int J Cancer. 1995 Apr 10;61(2):272–279. [PubMed]
  • Nanbu K, Konishi I, Komatsu T, Mandai M, Yamamoto S, Kuroda H, Koshiyama M, Mori T. Expression of heat shock proteins HSP70 and HSP90 in endometrial carcinomas. Correlation with clinicopathology, sex steroid receptor status, and p53 protein expression. Cancer. 1996 Jan 15;77(2):330–338. [PubMed]
  • Oesterreich S, Weng CN, Qiu M, Hilsenbeck SG, Osborne CK, Fuqua SA. The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Res. 1993 Oct 1;53(19):4443–4448. [PubMed]
  • Pinhasi-Kimhi O, Michalovitz D, Ben-Zeev A, Oren M. Specific interaction between the p53 cellular tumour antigen and major heat shock proteins. Nature. 1986 Mar 13;320(6058):182–184. [PubMed]
  • Pratt WB. Transformation of glucocorticoid and progesterone receptors to the DNA-binding state. J Cell Biochem. 1987 Sep;35(1):51–68. [PubMed]
  • Seymour L, Bezwoda WR, Meyer K. Tumor factors predicting for prognosis in metastatic breast cancer. The presence of P24 predicts for response to treatment and duration of survival. Cancer. 1990 Dec 1;66(11):2390–2394. [PubMed]
  • Shyamala G, Gauthier Y, Moore SK, Catelli MG, Ullrich SJ. Estrogenic regulation of murine uterine 90-kilodalton heat shock protein gene expression. Mol Cell Biol. 1989 Aug;9(8):3567–3570. [PMC free article] [PubMed]
  • Srivastava PK. Peptide-binding heat shock proteins in the endoplasmic reticulum: role in immune response to cancer and in antigen presentation. Adv Cancer Res. 1993;62:153–177. [PubMed]
  • Srivastava PK, DeLeo AB, Old LJ. Tumor rejection antigens of chemically induced sarcomas of inbred mice. Proc Natl Acad Sci U S A. 1986 May;83(10):3407–3411. [PMC free article] [PubMed]
  • Srivastava PK, Old LJ. Individually distinct transplantation antigens of chemically induced mouse tumors. Immunol Today. 1988 Mar;9(3):78–83. [PubMed]
  • Srivastava PK, Udono H, Blachere NE, Li Z. Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics. 1994;39(2):93–98. [PubMed]
  • Têtu B, Lacasse B, Bouchard HL, Lagacé R, Huot J, Landry J. Prognostic influence of HSP-27 expression in malignant fibrous histiocytoma: a clinicopathological and immunohistochemical study. Cancer Res. 1992 Apr 15;52(8):2325–2328. [PubMed]
  • Thiele CJ, Reynolds CP, Israel MA. Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma. Nature. 313(6001):404–406. [PubMed]
  • Tsuboi N, Ishikawa M, Tamura Y, Takayama S, Tobioka H, Matsuura A, Hirayoshi K, Nagata K, Sato N, Kikuchi K. Monoclonal antibody specifically reacting against 73-kilodalton heat shock cognate protein: possible expression on mammalian cell surface. Hybridoma. 1994 Oct;13(5):373–381. [PubMed]
  • Udono H, Srivastava PK. Heat shock protein 70-associated peptides elicit specific cancer immunity. J Exp Med. 1993 Oct 1;178(4):1391–1396. [PMC free article] [PubMed]
  • Ullrich SJ, Robinson EA, Law LW, Willingham M, Appella E. A mouse tumor-specific transplantation antigen is a heat shock-related protein. Proc Natl Acad Sci U S A. 1986 May;83(10):3121–3125. [PMC free article] [PubMed]
  • Ungar DR, Hailat N, Strahler JR, Kuick RD, Brodeur GM, Seeger RC, Reynolds CP, Hanash SM. Hsp27 expression in neuroblastoma: correlation with disease stage. J Natl Cancer Inst. 1994 May 18;86(10):780–784. [PubMed]
  • Vojtesek B, Kovarik J, Dolezalova H, Nenutil R, Havlis P, Brentani RR, Lane DP. Absence of p53 autoantibodies in a significant proportion of breast cancer patients. Br J Cancer. 1995 Jun;71(6):1253–1256. [PMC free article] [PubMed]
  • Yoshino I, Goedegebuure PS, Peoples GE, Lee KY, Eberlein TJ. Human tumor-infiltrating CD4+ T cells react to B cell lines expressing heat shock protein 70. J Immunol. 1994 Nov 1;153(9):4149–4158. [PubMed]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...