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Am J Pathol. Jan 1972; 66(1): 131–146.
PMCID: PMC2032479

Dupuytren's Contracture: Fibroblast Contraction?

An Ultrastructural Study

Abstract

In 6 cases of Dupuytren's disease and 1 of Ledderhose's disease, the nodules of the palmar and plantar aponeurosis were examined by light and electron microscopy. The cells composing these nodules, presumably fibroblasts, showed three significant ultrastructural features: (1) a fibrillar system similar to that of smooth muscle cells; (2) nuclear deformations such as are found in contracted cells, the severest being recognizable by light microscopy (cross-banded nuclei); (3) cell-to-cell and cell-to-stroma attachments. Based on these data and on recent information about the biology of the fibroblasts, it is suggested that these cells are fibroblasts that have modulated into contractile cells (myofibroblasts), and that their contraction plays a role in the pathogenesis of the contracture observed clinically.

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Selected References

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  • Wilkins John. The Chromosome Disorders. Proc R Soc Med. 1966 Sep;59(9):c922–923. [PMC free article]
  • LUCK JV. Dupuytren's contracture; a new concept of the pathogenesis correlated with surgical management. J Bone Joint Surg Am. 1959 Jun;41-A(4):635–664. [PubMed]
  • JAHNKE A. [Electron microscopic research on Dupuytren's contracture]. Zentralbl Chir. 1960 Nov 26;85:2295–2303. [PubMed]
  • Dahmen G. Feingewebliche und submikroskopische Befunde beim Morbus Dupuytren. Z Orthop Ihre Grenzgeb. 1968 Feb;104(2):247–254. [PubMed]
  • Gabbiani G, Ryan GB, Majne G. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia. 1971 May 15;27(5):549–550. [PubMed]
  • Majno G, Gabbiani G, Hirschel BJ, Ryan GB, Statkov PR. Contraction of granulation tissue in vitro: similarity to smooth muscle. Science. 1971 Aug 6;173(3996):548–550. [PubMed]
  • Majno G, Shea SM, Leventhal M. Endothelial contraction induced by histamine-type mediators: an electron microscopic study. J Cell Biol. 1969 Sep;42(3):647–672. [PMC free article] [PubMed]
  • Stehbens WE. The basal attachment of endothelial cells. J Ultrastruct Res. 1966 Jun;15(3):389–399. [PubMed]
  • LAGIER R, RUTISHAUSER E. Anatomie pathologique et pathogénie de la maladie de Dupuytren. Presse Med. 1956 Jun 27;64(51):1212–1216. [PubMed]
  • Lane BP. Alterations in the cytologic detail of intestinal smooth muscle cells in various stages of contraction. J Cell Biol. 1965 Oct;27(1):199–213. [PMC free article] [PubMed]
  • Bloom S, Cancilla PA. Conformational changes in myocardial nuclei of rats. Circ Res. 1969 Feb;24(2):189–196. [PubMed]
  • GOLDBERG B, GREEN H. AN ANALYSIS OF COLLAGEN SECRETION BY ESTABLISHED MOUSE FIBROBLAST LINES. J Cell Biol. 1964 Jul;22:227–258. [PMC free article] [PubMed]
  • Greenlee TK, Jr, Ross R. The development of the rat flexor digital tendon, a fine structure study. J Ultrastruct Res. 1967 May;18(3):354–376. [PubMed]
  • DEVIS R, JAMES DW. CLOSE ASSOCIATION BETWEEN ADULT GUINEA-PIG FIBROBLASTS IN TISSUE CULTURE, STUDIED WITH THE ELECTRON MICROSCOPE. J Anat. 1964 Jan;98:63–68. [PMC free article] [PubMed]
  • Moss NS, Benditt EP. Spontaneous and experimentally induced arterial lesions. I. An ultrastructural survey of the normal chicken aorta. Lab Invest. 1970 Feb;22(2):166–183. [PubMed]
  • O'Shea JD. An ultrastructural study of smooth muscle-like cells in the theca externa of ovarian follicles in the rat. Anat Rec. 1970 Jun;167(2):127–131. [PubMed]
  • HAUST MD, MORE RH, MOVAT HZ. The role of smooth muscle cells in the fibrogenesis of arteriosclerosis. Am J Pathol. 1960 Oct;37:377–389. [PMC free article] [PubMed]
  • Parker F, Odland GF. A light microscopic, histochemical and electron microscopic study of experimental atherosclerosis in rabbit coronary artery and a comparison with rabbit aorta atherosclerosis. Am J Pathol. 1966 Mar;48(3):451–481. [PMC free article] [PubMed]
  • James DW, Taylor JF. The stress developed by sheets of chick fibroblasts in vitro. Exp Cell Res. 1969 Jan;54(1):107–110. [PubMed]
  • HOFFMANN-BERLING H. Adenosintriphosphat als Betriebsstoff von Zellbewegungen. Biochim Biophys Acta. 1954 Jun;14(2):182–194. [PubMed]
  • Aron E. Le traitement médical de la maladie de Dupuytren par un agent cytostatique (méthyl-hydrazine) Presse Med. 1968 Oct 26;76(41):1956–1956. [PubMed]

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