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Journal List > Br J Cancer > v.42(1); Jul 1980

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Br J Cancer. 1980 July; 42(1): 95–102.
PMCID: PMC2010484
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Cell proliferation of colonic neoplasms in dimethylhydrazine-treated rats.
J. P. Sunter, D. L. Hull, D. R. Appleton, and A. J. Watson
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Abstract
We have measured mitotic indices and 3H-thymidine-labelling indices for the colonic epithelial tumours induced in rats by the administration of dimethyl-hydrazine (DMH). The fraction-of-labelled-mitoses (FLM) technique has been used to estimate the duration of the cell-cycle phases. In general, mitotic and labelling indices in the tumours are similar to those in the proliferation zone of the normal crypt epithelium; lesions considered to be least well differentiated on histological grounds appear to have the lowest mean labelling index. Benign tumours and the different types of malignant tumours have mean cell-cycle times about half those of the normal mucosa.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
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