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Journal List > Br J Cancer > v.30(2); Aug 1974

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Br J Cancer. 1974 August; 30(2): 142–145.
PMCID: PMC2009278
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Ascorbic Acid Deficiency in Malignant Diseases: A Clinical and Biochemical Study
N. Krasner and I. W. Dymock
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Abstract
In a study of the vitamin C status of 50 patients with malignant disease, 46 had leucocyte levels less than the lower limit of the normal range (18-50,μg/108 W.B.C.) and of these 30 had very low levels (< 12.5 μg/108 W.B.C.). Physical signs compatible with subclinical scurvy were frequently recorded and there was a significant decrease in capillary fragility in those with the lowest levels. Most patients had an inadequate dietary intake of ascorbic acid-containing foods and this was felt to be the major factor in producing the vitamin depletion.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Andrews J, Brook M. Leucocyte-vitamin-C content and clinical signs in the elderly. Lancet. 1966 Jun 18;1(7451):1350–1351. [PubMed]
  • Brocklehurst JC, Griffiths LL, Taylor GF, Marks J, Scott DL, Blackley J. The clinical features of chronic vitamin deficiency. A therapeutic trial in geriatric hospital patients. Gerontol Clin (Basel). 1968;10(5):309–320. [PubMed]
  • DENSON KW, BOWERS EF. The determination of ascorbic acid in white blood cells. A comparison of W.B.C. ascorbic acid and phenolic acid excretion in elderly patients. Clin Sci. 1961 Oct;21:157–162. [PubMed]
  • Dymock IW. Ascorbic acid status of healthy old people. Int Z Vitaminforsch. 1970;40(4):555–556. [PubMed]
  • Dymock IW, MacKay N, Miller V, Thomson TJ, Gray B, Kennedy EH, Adams JF. Small intestinal function in neoplastic disease. Br J Cancer. 1967 Sep;21(3):505–511. [PubMed]
  • Dymock SM, Brocklehurst JC. Clinical effects of water soluble vitamin supplementation in geriatric patients. Age Ageing. 1973 Aug;2(3):172–176. [PubMed]
  • Gibson SL, Moore FM, Goldberg A. Measurement of leucocyte ascorbic acid. Br Med J. 1966 May 7;1(5496):1152–1153. [PubMed]
  • Krasner N, Dymock IW. Measurement of capillary resistance by a negative pressure technique and its relationship to buffy layer ascorbic acid levels. Int Z Vitaminforsch. 1970;40(4):427–434. [PubMed]
  • Loh HS, Wilson CW. Relationship between leucocyte and plasma ascorbic acid concentrations. Br Med J. 1971 Sep 25;3(5777):733–735. [PubMed]
  • Sahud MA, Cohen RJ. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet. 1971 May 8;1(7706):937–938. [PubMed]
  • THOMSON TJ. Scurvy; a rare disease? Glasgow Med J. 1954 Dec;35(12):363–365. [PubMed]
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