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Br J Cancer. 1971 Jun; 25(2): 270–275.
PMCID: PMC2008453

A New Anti-oestrogenic Agent in Late Breast Cancer: An Early Clinical Appraisal of ICI46474


An introductory clinical trial of the anti-oestrogenic agent IC146474 in late or recurrent carcinoma of the breast is described.

Forty-six patients have been treated, of whom 10 have shown a good response. This is of the same order as that seen with oestrogens and androgens.

The particular advantage of this drug is the low incidence of troublesome side effects.

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Selected References

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  • Klopper A, Hall M. New synthetic agent for the induction of ovulation: preliminary trials in women. Br Med J. 1971 Jan 16;1(5741):152–154. [PMC free article] [PubMed]
  • Labhsetwar AP. Role of estrogens in ovulation: A study using the estrogen-antagonist, I.C.I. 46,474. Endocrinology. 1970 Sep;87(3):542–551. [PubMed]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK


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