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Br J Cancer. 1994 Jun; 69(6): 979–985.
PMCID: PMC1969431

Statistical aspects of prognostic factor studies in oncology.

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Selected References

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  • Altman DG. Categorising continuous variables. Br J Cancer. 1991 Nov;64(5):975–975. [PMC free article] [PubMed]
  • Altman DG, Andersen PK. Bootstrap investigation of the stability of a Cox regression model. Stat Med. 1989 Jul;8(7):771–783. [PubMed]
  • Blay JY, Lasset C, Carrie C, Chauvin F, Coiffier B, Gisselbrecht C, Clavel M, Rebattu P, Brunat-Mentigny M, Philip T, et al. Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring. Br J Cancer. 1993 May;67(5):1136–1141. [PMC free article] [PubMed]
  • Buyse ME. Analysis of clinical trial outcomes: some comments on subgroup analyses. Control Clin Trials. 1989 Dec;10(4 Suppl):187S–194S. [PubMed]
  • Courdi A, Héry M, Chauvel P, Gioanni J, Namer M, Demard F. Prognostic value of continuous variables in breast cancer and head and neck cancer. Dependence on the cut-off level. Br J Cancer. 1988 Jul;58(1):88–90. [PMC free article] [PubMed]
  • Cuzick J, Cooper EH, MacLennan IC. The prognostic value of serum beta 2 microglobulin compared with other presentation features in myelomatosis. Br J Cancer. 1985 Jul;52(1):1–6. [PMC free article] [PubMed]
  • Dixon DO, Simon R. Bayesian subset analysis in a colorectal cancer clinical trial. Stat Med. 1992 Jan 15;11(1):13–22. [PubMed]
  • Durrleman S, Simon R. Flexible regression models with cubic splines. Stat Med. 1989 May;8(5):551–561. [PubMed]
  • Eeles RA, Fisher C, A'Hern RP, Robinson M, Rhys-Evans P, Henk JM, Archer D, Harmer CL. Head and neck sarcomas: prognostic factors and implications for treatment. Br J Cancer. 1993 Jul;68(1):201–207. [PMC free article] [PubMed]
  • Fayers PM, Rustin G, Wood R, Nelstrop A, Leonard RCF, Wilkinson P, Cruickshank D, McAllister EJ, Redman CWE, Parker D, et al. The prognostic value of serum CA 125 in patients with advanced ovarian carcinoma: an analysis of 573 patients by the Medical Research Council Working Party on Gynaecological Cancer. Int J Gynecol Cancer. 1993 Sep;3(5):285–292. [PubMed]
  • Fisher B, Wolmark N, Rockette H, Redmond C, Deutsch M, Wickerham DL, Fisher ER, Caplan R, Jones J, Lerner H, et al. Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01. J Natl Cancer Inst. 1988 Mar 2;80(1):21–29. [PubMed]
  • Gail MH. Evaluating serial cancer marker studies in patients at risk of recurrent disease. Biometrics. 1981 Mar;37(1):67–78. [PubMed]
  • Gail M, Simon R. Testing for qualitative interactions between treatment effects and patient subsets. Biometrics. 1985 Jun;41(2):361–372. [PubMed]
  • Gasparini G, Pozza F, Harris AL. Evaluating the potential usefulness of new prognostic and predictive indicators in node-negative breast cancer patients. J Natl Cancer Inst. 1993 Aug 4;85(15):1206–1219. [PubMed]
  • George SL. Identification and assessment of prognostic factors. Semin Oncol. 1988 Oct;15(5):462–471. [PubMed]
  • Gray-Donald K, Kramer MS. Causality inference in observational vs. experimental studies. An empirical comparison. Am J Epidemiol. 1988 May;127(5):885–892. [PubMed]
  • Gregory WM. Adjusting survival curves for imbalances in prognostic factors. Br J Cancer. 1988 Aug;58(2):202–204. [PMC free article] [PubMed]
  • Harrell FE, Jr, Lee KL, Matchar DB, Reichert TA. Regression models for prognostic prediction: advantages, problems, and suggested solutions. Cancer Treat Rep. 1985 Oct;69(10):1071–1077. [PubMed]
  • Hastie T, Sleeper L, Tibshirani R. Flexible covariate effects in the proportional hazards model. Breast Cancer Res Treat. 1992;22(3):241–250. [PubMed]
  • Hauck WW, Miike R. A proposal for examining and reporting stepwise regressions. Stat Med. 1991 May;10(5):711–715. [PubMed]
  • Hilsenbeck SG, Clark GM, McGuire WL. Why do so many prognostic factors fail to pan out? Breast Cancer Res Treat. 1992;22(3):197–206. [PubMed]
  • Korn EL, Simon R. Measures of explained variation for survival data. Stat Med. 1990 May;9(5):487–503. [PubMed]
  • Levine MN, Browman GP, Gent M, Roberts R, Goodyear M. When is a prognostic factor useful? A guide for the perplexed. J Clin Oncol. 1991 Feb;9(2):348–356. [PubMed]
  • Lippman ME, Allegra JC, Thompson EB, Simon R, Barlock A, Green L, Huff KK, Do HM, Aitken SC, Warren R. The relation between estrogen receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer. N Engl J Med. 1978 Jun 1;298(22):1223–1228. [PubMed]
  • McGuire WL. Breast cancer prognostic factors: evaluation guidelines. J Natl Cancer Inst. 1991 Feb 6;83(3):154–155. [PubMed]
  • O'Reilly SM, Richards MA. Is DNA flow cytometry a useful investigation in breast cancer? Eur J Cancer. 1992;28(2-3):504–507. [PubMed]
  • Palmer MK, Hann IM, Jones PM, Evans DI. A score at diagnosis for predicting length of remission in childhood acute lymphoblastic leukaemia. Br J Cancer. 1980 Dec;42(6):841–849. [PMC free article] [PubMed]
  • Rawson NS, Peto J. An overview of prognostic factors in small cell lung cancer. A report from the Subcommittee for the Management of Lung Cancer of the United Kingdom Coordinating Committee on Cancer Research. Br J Cancer. 1990 Apr;61(4):597–604. [PMC free article] [PubMed]
  • Schmoor C, Ulm K, Schumacher M. Comparison of the Cox model and the regression tree procedure in analysing a randomized clinical trial. Stat Med. 1993 Dec 30;12(24):2351–2366. [PubMed]
  • Simon R. Patient subsets and variation in therapeutic efficacy. Br J Clin Pharmacol. 1982 Oct;14(4):473–482. [PMC free article] [PubMed]
  • Simon R. Confidence intervals for reporting results of clinical trials. Ann Intern Med. 1986 Sep;105(3):429–435. [PubMed]
  • Steyerberg EW, Keizer HJ, Zwartendijk J, Van Rijk GL, Van Groeningen CJ, Habbema JD, Stoter G. Prognosis after resection of residual masses following chemotherapy for metastatic nonseminomatous testicular cancer: a multivariate analysis. Br J Cancer. 1993 Jul;68(1):195–200. [PMC free article] [PubMed]
  • Tukey JW. Some thoughts on clinical trials, especially problems of multiplicity. Science. 1977 Nov 18;198(4318):679–684. [PubMed]

Articles from British Journal of Cancer are provided here courtesy of Cancer Research UK


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