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Can Med Assoc J. 1975 May 17; 112(10): 1173–1178. | PMCID: PMC1959113 |
Serum ferritin, cobalt excretion and body iron status. J. Sorbie, L. S. Valberg, W. E. Corbett, and J. Ludwig Abstract Serum ferritin concentration was measured by immunoradiometric assay in 64 subjects. It was closely related to the size of body iron stores measured by hemosiderin content of bone marrow in all subjects and by the deferoxamine test in 10 patients with iron overload. Urinary cobalt excretion, an indirect measure of iron absorption, was inversely related to hemosiderin content of bone marrow in 34 patients aged 18 to 72 with or without liver disease, but this relation did not hold in a group of 20 student volunteers aged 17 to 30, indicating that the test is unreliable in young people. A strong inverse correlation was demonstrated between values for cobalt excretion and serum ferritin in the 34 patients and between those for iron absorption and serum ferritin in the 20 students. Serum ferritin concentration appears to reflect accurately the iron status of the healthy individual but high values in liver disease must be interpreted with caution. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - REISSMANN KR, DIETRICH MR. On the presence of ferritin in the peripheral blood of patients with hepatocellular disease. J Clin Invest. 1956 Jun;35(6):588–595. [PubMed]
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