pmc logo image
Logo of canmedajCMAJ home pageCMAJ information for authors page
Journal List > Can Med Assoc J > v.106(4); Feb 19, 1972

Formats:
Can Med Assoc J. 1972 February 19; 106(4): 331–335.
PMCID: PMC1940416
Copyright notice
Inactivation of isoniazid by Canadian Eskimos and Indians
C. W. L. Jeanes, O. Schaefer, and L. Eidus
Small right arrow pointing to: This article has been cited by other articles in PMC.
Abstract
Phenotyping for isoniazid inactivation in Canadian Eskimos and Indians showed that the former are all fast acetylators, while only 63.4% of the Indians examined belonged to the same group. Further studies are suggested to confirm this initial finding.
During the investigation metabolic studies were carried out to devise a reliable urine test for phenotyping of isoniazid inactivators, to replace the fall-off technique which required venipunctures. The simplicity of the new urine test makes it suitable for mass examinations.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (928K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
 
icon of scanned page 331
331
icon of scanned page 332
332
icon of scanned page 333
333
icon of scanned page 334
334
icon of scanned page 335
335
 
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • SUNAHARA S, URANOM, OGAWAM Genetical and geographic studies on isoniazid inactivation. Science. 1961 Nov 10;134:1530–1531. [PubMed]
  • Tiitinen H, Mattila MJ, Eriksson AW. Comparison of the isoniazid inactivation in Finns and Lapps. Ann Med Intern Fenn. 1968;57(4):161–166. [PubMed]
  • ARMSTRONG AR, PEART HE. A comparison between the behavior of Eskimos and non-Eskimos to the administration of isoniazid. Am Rev Respir Dis. 1960 Apr;81:588–594. [PubMed]
  • HARRIS HW, KNIGHT RA, SELIN MJ. Comparison of isoniazid concentrations in the blood of people of Japanese and European descent; therapeutic and genetic implications. Am Rev Tuberc. 1958 Dec;78(6):944–948. [PubMed]
  • Hanngren A, Borgå O, Sjöqvist F. Inactivation of isoniazid (INH) in Swedish tuberculous patients before and during treatment with para-aminosalicylic acid (PAS). Scand J Respir Dis. 1970;51(1):61–69. [PubMed]
  • Eidus L, Harnanansingh AM. A more sensitive spectrophotometric method for determination of isoniazid in serum or plasma. Clin Chem. 1971 Jun;17(6):492–494. [PubMed]
  • Eidus L, Harnanansingh AM, Jessamine AG. Urine test for phenotyping isoniazid inactivators. Am Rev Respir Dis. 1971 Oct;104(4):587–591. [PubMed]
  • EIDUS L, HAMILTON EJ. A NEW METHOD FOR THE DETERMINATION OF N-ACETYL ISONIAZID IN URINE OF AMBULATORY PATIENTS. Am Rev Respir Dis. 1964 Apr;89:587–588. [PubMed]
  • Venkataraman P, Eidus L, Tripathy SP. Method for the estimation of acetylisoniazid in urine. Tubercle. 1968 Jun;49(2):210–216. [PubMed]
  • DUFOUR AP, KNIGHT RA, HARRIS HW. GENETICS OF ISONIAZID METABOLISM IN CAUCASIAN, NEGRO, AND JAPANESE POPULATIONS. Science. 1964 Jul 24;145:391–391. [PubMed]
  • Peters JH, Miller KS, Brown P. Studies on the metabolic basis for the genetically determined capacities for isoniazid inactivation in man. J Pharmacol Exp Ther. 1965 Nov;150(2):298–304. [PubMed]
  • IWAINSKY H, GERLOFF W, SCHMIEDEL A. [The differentiation between isoniazid-inactivating and normally catabolizing patients by means of a simple test.]. Beitr Klin Tuberk Spezif Tuberkuloseforsch. 1961;124:384–389. [PubMed]
  • TEICHMANN W, KOEHLER R. BEITRAG ZUR SCHNELLEN DIFFERENZIERUNG DES INDIVIDUELLEN INH-STOFFWECHSELS. Prax Pneumol. 1964 Aug;18:535–541. [PubMed]
  • MAIER N, MOISESCU V. EINE SCHNELLE METHODE ZUR BESTIMMUNG DER KONZENTRATION DES DURCH DIE NIEREN AUSGESCHIEDENEN INH. Beitr Klin Tuberk Spezif Tuberkuloseforsch. 1964 May 27;128:213–217. [PubMed]
  • Scott EM, Wright RC, Weaver DD. The discrimination of phenotypes for rate of disappearance of isonicotinoyl hydrazide from serum. J Clin Invest. 1969 Jul;48(7):1173–1176. [PubMed]
  • Tiitinen H. Isoniazid inactivation status and the development of chronic tuberculosis. Scand J Respir Dis. 1969;50(3):227–234. [PubMed]
  • JESSAMINE AG, HAMILTON EJ, EIDUS L. A CLINICAL STUDY OF ISONIAZID INACTIVATION. Can Med Assoc J. 1963 Dec 14;89:1214–1217. [PubMed]
  • IWAINSKY H, KAUFFMANN GW, SIEGEL D, GERISCHER C. [On the effect of INH metabolism on the therapy of pulmonary tuberculosis.]. Beitr Klin Tuberk Spezif Tuberkuloseforsch. 1960;122:324–332. [PubMed]
  • MITCHELL RS, BELL JC. Clinical implications of isoniazid blood levels in pulmonary tuberculosis. N Engl J Med. 1957 Nov 28;257(22):1066–1070. [PubMed]
  • Mydlak G, Volkmann W. Die Bedeutung der INH-Stoffwechselanalyse für die Therapie. II. Z Tuberk Erkr Thoraxorg. 1965 Nov;124(1):44–48. [PubMed]
  • Russell DW. Simple method for determining isoniazid acetylator phenotype. Br Med J. 1970 Aug 8;3(5718):324–325. [PubMed]
Articles from Canadian Medical Association Journal are provided here courtesy of
Canadian Medical Association

PubMed articles by these authors