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Can Med Assoc J. 1970 November 21; 103(11): 1157–1160. | PMCID: PMC1930619 |
The Role of Rubella in the Etiology of Supravalvular Aortic Stenosis Dennis J. Vince Abstract The possibility of an etiological relationship between rubella embryopathy and sporadic forms of supravalvular aortic stenosis is considered. A case is presented of a patient with rubella embryopathy and supravalvular aortic stenosis associated with pulmonary valvular and peripheral pulmonary artery stenosis, bicuspid aortic valve, aortic valve stenosis and subendothelial myocardial fibrosis. A review of the literature revealed many clinical and pathological features common to both syndromes. The hypothesis that rubella virus produced germ-cell mutation and subsequent persistence of rubella in the zygote produced further fetal damage is presented to explain these observations. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.9M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. Images in this article Click on the image to see a larger version. These references are in PubMed. This may not be the complete list of references from this article. - WILLIAMS JC, BARRATT-BOYES BG, LOWE JB. Supravalvular aortic stenosis. Circulation. 1961 Dec;24:1311–1318. [PubMed]
- DENIE JJ, VERHEUGT AP. Supravalvular aortic stenosis. Circulation. 1958 Nov;18(5):902–908. [PubMed]
- SISSMAN NJ, NEILL CA, SPENCER FC, TAUSSIG HB. Congenital aortic stenosis. Circulation. 1959 Mar;19(3):458–468. [PubMed]
- LOGAN WF, JONES EW, WALKER E, COULSHED N, EPSTEIN EJ. FAMILIAL SUPRAVALVAR AORTIC STENOSIS. Br Heart J. 1965 Jul;27:547–559. [PubMed]
- Rastelli GC, McGoon DC, Ongley PA, Mankin HT, Kirklin JW. Surgical treatment of supravalvular aortic stenosis. Report of 16 cases and review of literature. J Thorac Cardiovasc Surg. 1966 Jun;51(6):873–882. [PubMed]
- Lewis AJ, Ongley PA, Kincaid OW, Ritter DG. Supravalvular aortic stenosis. Report of a family with peculiar somatic features and normal intelligence. Dis Chest. 1969 May;55(5):372–379. [PubMed]
- Ottesen OE, Antia AU, Rowe RD. Peripheral vascular anomalies associated with the supravalvular aortic stenosis syndrome. Radiology. 1966 Mar;86(3):430–435. [PubMed]
- Fay JE, Lynn RB, Partington MW. Supravalvular aortic stenosis, mental retardation and a characteristic facies. Can Med Assoc J. 1966 Feb 5;94(6):295–297. [PubMed]
- FRANCH RH, GAY BB., Jr CONGENITAL STENOSIS OF THE PULMONARY ARTERY BRANCHES. A CLASSIFICATION, WITH POSTMORTEM FINDINGS IN TWO CASES. Am J Med. 1963 Oct;35:512–529. [PubMed]
- ROWE RD. MATERNAL RUBELLA AND PULMONARY ARTERY STENOSES. REPORT OF ELEVEN CASES. Pediatrics. 1963 Aug;32:180–185. [PubMed]
- BOURASSA MG, CAMPEAU L. COMBINED SUPRAVALVULAR AORTIC AND PULMONIC STENOSIS. Circulation. 1963 Oct;28:572–581. [PubMed]
- Ainger LE, Lawyer NG, Fitch CW. Neonatal rubella myocarditis. Br Heart J. 1966 Sep;28(5):691–697. [PubMed]
- CAMPBELL PE. VASCULAR ABNORMALITIES FOLLOWING MATERNAL RUBELLA. Br Heart J. 1965 Jan;27:134–138. [PubMed]
- Chantler C, Davies DH, Joseph MC. Cardiovascular and other associations of infantile hypercalcaemia. Guys Hosp Rep. 1966;115(2):221–241. [PubMed]
- Achs R, Harper RG, Siegel M. Unusual dermatoglyphic findings associated with rubella embryopathy. N Engl J Med. 1966 Jan 20;274(3):148–150. [PubMed]
- Way RC. Cardiovascular defects and the rubella syndrome. Can Med Assoc J. 1967 Nov 25;97(22):1329–1334. [PubMed]
- PEROU ML. Congenital supravalvular aortic stenosis. A morphological study with attempt at classification. Arch Pathol. 1961 Apr;71:453–466. [PubMed]
- Nusbacher J, Hirschhorn K, Cooper LZ. Chromosomal abnormalities in congenital rubella. N Engl J Med. 1967 Jun 22;276(25):1409–1413. [PubMed]
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