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Am J Hum Genet. Apr 1994; 54(4): 705–714.
PMCID: PMC1918089

Maximum-likelihood estimation of gene location by linkage disequilibrium.

Abstract

Linkage disequilibrium, D, between a polymorphic disease and mapped markers can, in principle, be used to help find the map position of the disease gene. Likelihoods are therefore derived for the value of D conditional on the observed number of haplotypes in the sample and on the population parameter Nc, where N is the effective population size and c the recombination fraction between the disease and marker loci. The likelihood is computed explicitly for the case of two loci with heterozygote superiority and, more generally, by computer simulations assuming a steady state of constant population size and selective pressures or neutrality. It is found that the likelihood is, in general, not very dependent on the degree of selection at the loci and is very flat. This suggests that precise information on map position will not be obtained from estimates of linkage disequilibrium.

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Selected References

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  • Bodmer WF. Human genetics: the molecular challenge. Cold Spring Harb Symp Quant Biol. 1986;51(Pt 1):1–13. [PubMed]
  • Estivill X, Farrall M, Scambler PJ, Bell GM, Hawley KM, Lench NJ, Bates GP, Kruyer HC, Frederick PA, Stanier P, et al. A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands. Nature. 326(6116):840–845. [PubMed]
  • Hästbacka J, de la Chapelle A, Kaitila I, Sistonen P, Weaver A, Lander E. Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland. Nat Genet. 1992 Nov;2(3):204–211. [PubMed]
  • Hill WG, Weir BS. Variances and covariances of squared linkage disequilibria in finite populations. Theor Popul Biol. 1988 Feb;33(1):54–78. [PubMed]
  • Hudson RR. The sampling distribution of linkage disequilibrium under an infinite allele model without selection. Genetics. 1985 Mar;109(3):611–631. [PMC free article] [PubMed]
  • Kaplan N, Weir BS. Expected behavior of conditional linkage disequilibrium. Am J Hum Genet. 1992 Aug;51(2):333–343. [PMC free article] [PubMed]
  • MacDonald ME, Novelletto A, Lin C, Tagle D, Barnes G, Bates G, Taylor S, Allitto B, Altherr M, Myers R, et al. The Huntington's disease candidate region exhibits many different haplotypes. Nat Genet. 1992 May;1(2):99–103. [PubMed]
  • Pritchard C, Cox DR, Myers RM. The end in sight for Huntington disease? Am J Hum Genet. 1991 Jul;49(1):1–6. [PMC free article] [PubMed]
  • Sved JA, Feldman MW. Correlation and probability methods for one and two loci. Theor Popul Biol. 1973 Mar;4(1):129–132. [PubMed]

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