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Am J Pathol. 1983 August; 112(2): 218–223. | PMCID: PMC1916261 |
Phenytoin sensitivity of fibroblasts as the basis for susceptibility to gingival enlargement. T. M. Hassell and G. H. Gilbert Abstract A side effect of long-term administration of the anti-epileptic drug phenytoin is overgrowth of the connective tissues surrounding the teeth. In this in vitro study of protein and collagen synthesis by diploid fibroblasts from 17 nonepileptic young persons with healthy gingivae, only seven strains of cells responded to phenytoin in culture medium. Because not all phenytoin-treated individuals develop gingival overgrowth, we suggest that susceptibility is predicated upon the presence of a (genetically determined) phenytoin-sensitive subpopulation of gingival fibroblasts. The concept of the participation of sensitive cell subpopulations in other connective tissue disorders is supported by these findings. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. Images in this article Click on the image to see a larger version. These references are in PubMed. This may not be the complete list of references from this article. - Hassell TM, Page RC, Lindhe J. Histologic evidence for impaired growth control in diphenylhydantoin gingival overgrowth in man. Arch Oral Biol. 1978;23(5):381–384. [PubMed]
- Han SS, Hwang PJ, Lee OH. A study of the histopathology of gingival hyperplasia in mental patients receiving sodium diphenylhydantoinate. Oral Surg Oral Med Oral Pathol. 1967 Jun;23(6):774–786. [PubMed]
- Hall BK, Squier CA. Ultrastructural quantitation of connective tissue changes in phenytoin-induced gingival overgrowth in the ferret. J Dent Res. 1982 Jul;61(7):942–952. [PubMed]
- Hassell TM, Page RC, Narayanan AS, Cooper CG. Diphenylhydantoin (dilantin) gingival hyperplasia: drug-induced abnormality of connective tissue. Proc Natl Acad Sci U S A. 1976 Aug;73(8):2909–2912. [PubMed]
- Ko SD, Page RC, Narayanan AS. Fibroblast heterogeneity and prostaglandin regulation of subpopulations. Proc Natl Acad Sci U S A. 1977 Aug;74(8):3429–3432. [PubMed]
- Kasai S, Hachimine K. Effect of 5, 5-diphenylhydantoin sodium on the synthesis of collagen by some fibroblastic cell lines including gingiva derived cells. Bull Tokyo Dent Coll. 1974 May;15(2):53–62. [PubMed]
- Houck JC, Cheng RF, Waters MD. The effect of dilantin upon fibroblast proliferation. Proc Soc Exp Biol Med. 1972 Mar;139(3):969–971. [PubMed]
- Kasai S, Yoshizumi T. Effect of diphenylhydantoin sodium on the proliferation of cultured cells in vitro. Bull Tokyo Dent Coll. 1971 Aug;12(3):223–234. [PubMed]
- Blumenkrantz N, Asboe-Hansen G. Effect of diphenylhydantoin on connective tissue. Acta Neurol Scand. 1974;50(3):302–306. [PubMed]
- Liu TZ, Bhatnagar RS. Inhibition of protocollagen proline hydroxylase by Dilantin. Proc Soc Exp Biol Med. 1973 Jan;142(1):253–255. [PubMed]
- SILNESS J, LOE H. PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION. Acta Odontol Scand. 1964 Feb;22:121–135. [PubMed]
- Mühlemann HR, Son S. Gingival sulcus bleeding--a leading symptom in initial gingivitis. Helv Odontol Acta. 1971 Oct;15(2):107–113. [PubMed]
- Dudley KH, Bius DL, Kraus BL, Boyles LW. Gas chromatographic on-column methylation technique for the simulataneous determination of antiepileptic drugs in blood. Epilepsia. 1977 Jun;18(2):259–276. [PubMed]
- Angelopoulos AP, Goaz PW. Incidence of diphenylhydantoin gingival hyperplasia. Oral Surg Oral Med Oral Pathol. 1972 Dec;34(6):898–906. [PubMed]
- Peterkofsky B, Diegelmann R. Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins. Biochemistry. 1971 Mar 16;10(6):988–994. [PubMed]
- Ko SD, Narayanan AS, Page RC. Influence of cell cycle on collagen synthesis by human gingival fibroblasts. J Periodontal Res. 1981 May;16(3):302–308. [PubMed]
- Hassell TM, Roebuck S, Page RC, Wray SH. Quantitative histopathologic assessment of developing phenytoin-induced gingival overgrowth in the cat. J Clin Periodontol. 1982 Sep;9(5):365–372. [PubMed]
- Hassell TM, Page RC. The major metabolite of phenytoin (Dilantin) induces gingival overgrowth in cats. J Periodontal Res. 1978 May;13(3):280–282. [PubMed]
- Houck JC, Sharma VK, Hayflick L. Functional failures of cultured human diploid fibroblasts after continued population doublings. Proc Soc Exp Biol Med. 1971 May;137(1):331–333. [PubMed]
- da Keith, Paz MA, Gallop PM. The effect of diphenylhydantoin on fibroblasts in vitro. J Dent Res. 1977 Oct;56(10):1279–1283. [PubMed]
- Bazin S, Delaunay A. Action exercée par la diphénylhydantoïne sur la maturation du collagène dans la peau normale et un tissu granulomateux. C R Acad Sci Hebd Seances Acad Sci D. 1972 Jul 17;275(3):509–511. [PubMed]
- Ebadi MS, Scott PM. Increase in collagen level by diphenylhydantoin as possible mechanism of drug-induced gingival hyperplasia. Clin Toxicol. 1971 Mar;4(1):39–46. [PubMed]
- SHAPIRO M. Acceleration of gingival wound healing in non-epileptic patients receiving diphenylhydantoin sodium (dilantin, epanutin). Exp Med Surg. 1958;16(1):41–53. [PubMed]
- SHAFER WG, BEATTY RE, DAVIS WB. Effect of dilantin sodium on tensile strength of healing wounds. Proc Soc Exp Biol Med. 1958 Jun;98(2):348–350. [PubMed]
- SIMPSON GM, KUNZ E, SLAFTA J. USE OF SODIUM DIPHENYLHYDANTOIN IN TREATMENT OF LEG ULCERS. N Y State J Med. 1965 Apr 1;65:886–888. [PubMed]
- Kusek JC. The effects of phenytoin on in vitro protein synthesis in oral and non-oral tissues of the rat. Arch Oral Biol. 1980;25(11-12):745–747. [PubMed]
- Seeman P, Chau-Wong M, Moyyen S. The membrane binding of morphine, diphenylhydantoin, and tetrahydrocannabinol. Can J Physiol Pharmacol. 1972 Dec;50(12):1193–1200. [PubMed]
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