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Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution
Jesse D Bloom, Philip A Romero, Zhongyi Lu, Frances H Arnold
Biol Direct. 2007; 2: 17. Published online 2007 June 28. doi: 10.1186/1745-6150-2-17
PMCID:
PMC1914045
Abstract Full Text PDF–447K Supplementary Material
 Is Cited by the Following 14 Articles in this Archive:
Patterns of Positive Selection and Neutral Evolution in the Protein-Coding Genes of Tetraodon and Takifugu
Juan I. Montoya-Burgos
PLoS One. 2011; 6(9): e24800. Published online 2011 September 13. doi: 10.1371/journal.pone.0024800
PMCID:
PMC3172292
Abstract Full Text PDF–190K Supplementary Material
Mining Endonuclease Cleavage Determinants in Genomic Sequence Data
Mindy D. Szeto, Sandrine J. S. Boissel, David Baker, Summer B. Thyme
J Biol Chem. 2011 September 16; 286(37): 32617–32627. Published online 2011 July 21. doi: 10.1074/jbc.M111.259572
PMCID:
PMC3173205
Abstract Full Text Supplementary Material
Applying neutral drift to the directed molecular evolution of a β-glucuronidase into a β-galactosidase: Two different evolutionary pathways lead to the same variant
Wendy S Smith, Jennifer R Hale, Cameron Neylon
BMC Res Notes. 2011; 4: 138. Published online 2011 May 6. doi: 10.1186/1756-0500-4-138
PMCID:
PMC3118342
Abstract Full Text PDF–705K Supplementary Material
Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift
Jason R. Cantor, Tae Hyeon Yoo, Aakanksha Dixit, Brent L. Iverson, Thomas G. Forsthuber, George Georgiou
Proc Natl Acad Sci U S A. 2011 January 25; 108(4): 1272–1277. Published online 2011 January 5. doi: 10.1073/pnas.1014739108
PMCID:
PMC3029727
Abstract Full Text PDF–786K Supplementary Material
Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control
Effendi Leonard, Parayil Kumaran Ajikumar, Kelly Thayer, Wen-Hai Xiao, Jeffrey D. Mo, Bruce Tidor, Gregory Stephanopoulos, Kristala L. J. Prather
Proc Natl Acad Sci U S A. 2010 August 3; 107(31): 13654–13659. Published online 2010 July 19. doi: 10.1073/pnas.1006138107
PMCID:
PMC2922259
Abstract Full Text PDF–1.0M Supplementary Material
Evolvability and Single-Genotype Fluctuation in Phenotypic Properties: A Simple Heteropolymer Model
Tao Chen, David Vernazobres, Tetsuya Yomo, Erich Bornberg-Bauer, Hue Sun Chan
Biophys J. 2010 June 2; 98(11): 2487–2496. doi: 10.1016/j.bpj.2010.02.046
PMCID:
PMC2877360
Abstract Full Text PDF–2.0M Supplementary Material
Evolutionary Plasticity and Innovations in Complex Metabolic Reaction Networks
João F. Matias Rodrigues, Andreas Wagner
PLoS Comput Biol. 2009 December; 5(12): e1000613. Published online 2009 December 18. doi: 10.1371/journal.pcbi.1000613
PMCID:
PMC2785887
Abstract Full Text PDF–785K Supplementary Material
Exploring protein fitness landscapes by directed evolution
Philip A. Romero, Frances H. Arnold
Nat Rev Mol Cell Biol. Author manuscript; available in PMC 2010 December 6.
Published in final edited form as: Nat Rev Mol Cell Biol. 2009 December; 10(12): 866–876. doi: 10.1038/nrm2805
PMCID:
PMC2997618
Abstract Full Text PDF–929K
Markers of Fitness in a Successful Enzyme Superfamily
Karen N. Allen, Debra Dunaway-Mariano
Curr Opin Struct Biol. Author manuscript; available in PMC 2010 December 1.
Published in final edited form as: Curr Opin Struct Biol. 2009 December; 19(6): 658–665. Published online 2009 November 2. doi: 10.1016/j.sbi.2009.09.008
PMCID:
PMC2787785
Abstract Full Text PDF–2.3M
In the light of directed evolution: Pathways of adaptive protein evolution
Jesse D. Bloom, Frances H. Arnold
Proc Natl Acad Sci U S A. 2009 June 16; 106(Supplement_1): 9995–10000. Published online 2009 June 15. doi: 10.1073/pnas.0901522106
PMCID:
PMC2702793
Abstract Full Text PDF–614K
Directed enzyme evolution: climbing fitness peaks one amino acid at a time
Cara A Tracewell, Frances H Arnold
Curr Opin Chem Biol. Author manuscript; available in PMC 2009 June 29.
Published in final edited form as: Curr Opin Chem Biol. 2009 February; 13(1): 3–9. Published online 2009 February 25. doi: 10.1016/j.cbpa.2009.01.017
PMCID:
PMC2703427
Abstract Full Text PDF–732K
Evolution of Hormone Signaling in Elasmobranchs by Exploitation of Promiscuous Receptors
Sean Michael Carroll, Jamie T. Bridgham, Joseph W. Thornton
Mol Biol Evol. 2008 December; 25(12): 2643–2652. Published online 2008 September 17. doi: 10.1093/molbev/msn204
PMCID:
PMC2721552
Abstract Full Text PDF–556K Supplementary Material
Principal Component Analysis of CYP2C9 and CYP3A4 Probe Substrate/Inhibitor Panels
Abhinav Nath, William Atkins
Drug Metab Dispos. Author manuscript; available in PMC 2008 November 2.
Published in final edited form as: Drug Metab Dispos. 2008 November; 36(11): 2151–2155. Published online 2008 June 19. doi: 10.1124/dmd.108.022061
PMCID:
PMC2577166
Abstract Full Text PDF–368K
Evolution favors protein mutational robustness in sufficiently large populations
Jesse D Bloom, Zhongyi Lu, David Chen, Alpan Raval, Ophelia S Venturelli, Frances H Arnold
BMC Biol. 2007; 5: 29. Published online 2007 July 17. doi: 10.1186/1741-7007-5-29
PMCID:
PMC1995189
Abstract Full Text PDF–510K Supplementary Material
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