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Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution
Jesse D Bloom, Philip A Romero, Zhongyi Lu, Frances H Arnold
Biol Direct. 2007; 2: 17. Published online 2007 June 28. doi: 10.1186/1745-6150-2-17
PMCID:
PMC1914045
Abstract Full Text PDF–447K Supplementary Material

Is Cited by the Following 17 Articles in this Archive:

Enzyme functional evolution through improved catalysis of ancestrally nonpreferred substrates
Ruiqi Huang, Frank Hippauf, Diana Rohrbeck, Maria Haustein, Katrin Wenke, Janie Feike, Noah Sorrelle, Birgit Piechulla, Todd J. Barkman
Proc Natl Acad Sci U S A. 2012 February 21; 109(8): 2966–2971. Published online 2012 February 6. doi: 10.1073/pnas.1019605109
PMCID:
PMC3286912
Free in PMC on 2012/08/21
The role of robustness in phenotypic adaptation and innovation
Andreas Wagner
Proc Biol Sci. 2012 April 7; 279(1732): 1249–1258. Published online 2012 January 4. doi: 10.1098/rspb.2011.2293
PMCID:
PMC3282381
Free in PMC on 2013/04/07
Origins of Specificity and Promiscuity in Metabolic Networks
Pablo Carbonell, Guillaume Lecointre, Jean-Loup Faulon
J Biol Chem. 2011 December 23; 286(51): 43994–44004. Published online 2011 November 3. doi: 10.1074/jbc.M111.274050
PMCID:
PMC3243566
Free in PMC on 2012/12/23
Patterns of Positive Selection and Neutral Evolution in the Protein-Coding Genes of Tetraodon and Takifugu
Juan I. Montoya-Burgos
PLoS One. 2011; 6(9): e24800. Published online 2011 September 13. doi: 10.1371/journal.pone.0024800
PMCID:
PMC3172292
Abstract Full Text PDF–190K Supplementary Material
Mining Endonuclease Cleavage Determinants in Genomic Sequence Data
Mindy D. Szeto, Sandrine J. S. Boissel, David Baker, Summer B. Thyme
J Biol Chem. 2011 September 16; 286(37): 32617–32627. Published online 2011 July 21. doi: 10.1074/jbc.M111.259572
PMCID:
PMC3173205
Abstract Full Text Supplementary Material
Applying neutral drift to the directed molecular evolution of a β-glucuronidase into a β-galactosidase: Two different evolutionary pathways lead to the same variant
Wendy S Smith, Jennifer R Hale, Cameron Neylon
BMC Res Notes. 2011; 4: 138. Published online 2011 May 6. doi: 10.1186/1756-0500-4-138
PMCID:
PMC3118342
Abstract Full Text PDF–705K Supplementary Material
Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift
Jason R. Cantor, Tae Hyeon Yoo, Aakanksha Dixit, Brent L. Iverson, Thomas G. Forsthuber, George Georgiou
Proc Natl Acad Sci U S A. 2011 January 25; 108(4): 1272–1277. Published online 2011 January 5. doi: 10.1073/pnas.1014739108
PMCID:
PMC3029727
Abstract Full Text PDF–786K Supplementary Material
Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control
Effendi Leonard, Parayil Kumaran Ajikumar, Kelly Thayer, Wen-Hai Xiao, Jeffrey D. Mo, Bruce Tidor, Gregory Stephanopoulos, Kristala L. J. Prather
Proc Natl Acad Sci U S A. 2010 August 3; 107(31): 13654–13659. Published online 2010 July 19. doi: 10.1073/pnas.1006138107
PMCID:
PMC2922259
Abstract Full Text PDF–1.0M Supplementary Material
Evolvability and Single-Genotype Fluctuation in Phenotypic Properties: A Simple Heteropolymer Model
Tao Chen, David Vernazobres, Tetsuya Yomo, Erich Bornberg-Bauer, Hue Sun Chan
Biophys J. 2010 June 2; 98(11): 2487–2496. doi: 10.1016/j.bpj.2010.02.046
PMCID:
PMC2877360
Abstract Full Text PDF–2.0M Supplementary Material
Evolutionary Plasticity and Innovations in Complex Metabolic Reaction Networks
João F. Matias Rodrigues, Andreas Wagner
PLoS Comput Biol. 2009 December; 5(12): e1000613. Published online 2009 December 18. doi: 10.1371/journal.pcbi.1000613
PMCID:
PMC2785887
Abstract Full Text PDF–785K Supplementary Material
Exploring protein fitness landscapes by directed evolution
Philip A. Romero, Frances H. Arnold
Nat Rev Mol Cell Biol. Author manuscript; available in PMC 2010 December 6.
Published in final edited form as: Nat Rev Mol Cell Biol. 2009 December; 10(12): 866–876. doi: 10.1038/nrm2805
PMCID:
PMC2997618
Abstract Full Text PDF–929K
Markers of Fitness in a Successful Enzyme Superfamily
Karen N. Allen, Debra Dunaway-Mariano
Curr Opin Struct Biol. Author manuscript; available in PMC 2010 December 1.
Published in final edited form as: Curr Opin Struct Biol. 2009 December; 19(6): 658–665. Published online 2009 November 2. doi: 10.1016/j.sbi.2009.09.008
PMCID:
PMC2787785
Abstract Full Text PDF–2.3M
In the light of directed evolution: Pathways of adaptive protein evolution
Jesse D. Bloom, Frances H. Arnold
Proc Natl Acad Sci U S A. 2009 June 16; 106(Supplement_1): 9995–10000. Published online 2009 June 15. doi: 10.1073/pnas.0901522106
PMCID:
PMC2702793
Abstract Full Text PDF–614K
Directed enzyme evolution: climbing fitness peaks one amino acid at a time
Cara A Tracewell, Frances H Arnold
Curr Opin Chem Biol. Author manuscript; available in PMC 2009 June 29.
Published in final edited form as: Curr Opin Chem Biol. 2009 February; 13(1): 3–9. Published online 2009 February 25. doi: 10.1016/j.cbpa.2009.01.017
PMCID:
PMC2703427
Abstract Full Text PDF–732K
Evolution of Hormone Signaling in Elasmobranchs by Exploitation of Promiscuous Receptors
Sean Michael Carroll, Jamie T. Bridgham, Joseph W. Thornton
Mol Biol Evol. 2008 December; 25(12): 2643–2652. Published online 2008 September 17. doi: 10.1093/molbev/msn204
PMCID:
PMC2721552
Abstract Full Text PDF–556K Supplementary Material
Principal Component Analysis of CYP2C9 and CYP3A4 Probe Substrate/Inhibitor Panels
Abhinav Nath, William Atkins
Drug Metab Dispos. Author manuscript; available in PMC 2008 November 2.
Published in final edited form as: Drug Metab Dispos. 2008 November; 36(11): 2151–2155. Published online 2008 June 19. doi: 10.1124/dmd.108.022061
PMCID:
PMC2577166
Abstract Full Text PDF–368K
Evolution favors protein mutational robustness in sufficiently large populations
Jesse D Bloom, Zhongyi Lu, David Chen, Alpan Raval, Ophelia S Venturelli, Frances H Arnold
BMC Biol. 2007; 5: 29. Published online 2007 July 17. doi: 10.1186/1741-7007-5-29
PMCID:
PMC1995189
Abstract Full Text PDF–510K Supplementary Material
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