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Br J Pharmacol. Nov 1991; 104(3): 765–767.
PMCID: PMC1908235

Interleukin-8 as a mediator of sympathetic pain.

Abstract

1. The hyperalgesic effects of interleukin-8 (IL-8), interleukin-1 beta (IL-1 beta) and carrageenin were measured in a rat paw pressure test. 2. IL-8 evoked a dose-dependent hyperalgesia which was attenuated by a specific antiserum, the beta-adrenoceptor antagonists atenolol and propranolol, the dopamine receptor antagonist SCH 23390 and the adrenergic neurone-blocking agent guanethidine. The hyperalgesia was not attenuated by the cyclooxygenase inhibitor indomethacin or the IL-1 beta analogue Lys-D-Pro-Thr. 3. IL-1 beta-evoked hyperalgesia was attenuated by indomethacin and Lys-D-Pro-Thr but not by atenolol or SCH 23390. 4. Carrageenin-evoked hyperalgesia was attenuated by atenolol, indomethacin and anti-IL-8 serum. The effects of atenolol and anti-IL-8 serum were not additive. The effects of indomethacin and anti-IL-8 serum were additive: this combination abolished carrageenin-evoked hyperalgesia. 5. A new biological activity of IL-8 is described, namely the capacity to evoke hyperalgesia by a prostaglandin-independent mechanism. IL-8 is the first endogenous mediator to be identified as evoking hyperalgesia involving the sympathetic nervous system. Since IL-8 is released by activated macrophages and endothelial cells it may be a humoral link between tissue injury and sympathetic hyperalgesia.

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Selected References

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  • BURN JH, RAND MJ. The action of sympathomimetic amines in animals treated with reserpine. J Physiol. 1958 Dec 4;144(2):314–336. [PMC free article] [PubMed]
  • CHANG CC, COSTA E, BRODIE BB. INTERACTION OF GUANETHIDINE WITH ADRENERGIC NEURONS. J Pharmacol Exp Ther. 1965 Mar;147:303–312. [PubMed]
  • Coderre TJ, Abbott FV, Melzack R. Effects of peripheral antisympathetic treatments in the tail-flick, formalin and autotomy tests. Pain. 1984 Jan;18(1):13–23. [PubMed]
  • Duarte ID, Nakamura M, Ferreira SH. Participation of the sympathetic system in acetic acid-induced writhing in mice. Braz J Med Biol Res. 1988;21(2):341–343. [PubMed]
  • Ferreira SH, Lorenzetti BB, Bristow AF, Poole S. Interleukin-1 beta as a potent hyperalgesic agent antagonized by a tripeptide analogue. Nature. 1988 Aug 25;334(6184):698–700. [PubMed]
  • Ferreira SH, Lorenzetti BB, Corrêa FM. Central and peripheral antialgesic action of aspirin-like drugs. Eur J Pharmacol. 1978 Dec 15;53(1):39–48. [PubMed]
  • Gimbrone MA, Jr, Obin MS, Brock AF, Luis EA, Hass PE, Hébert CA, Yip YK, Leung DW, Lowe DG, Kohr WJ, et al. Endothelial interleukin-8: a novel inhibitor of leukocyte-endothelial interactions. Science. 1989 Dec 22;246(4937):1601–1603. [PubMed]
  • Hannington-Kiff JG. Intravenous regional sympathetic block with guanethidine. Lancet. 1974 May 25;1(7865):1019–1020. [PubMed]
  • Kebabian JW, Calne DB. Multiple receptors for dopamine. Nature. 1979 Jan 11;277(5692):93–96. [PubMed]
  • Loh L, Nathan PW, Schott GD. Pain due to lesions of central nervous system removed by sympathetic block. Br Med J (Clin Res Ed) 1981 Mar 28;282(6269):1026–1028. [PMC free article] [PubMed]
  • Nakamura M, Ferreira SH. A peripheral sympathetic component in inflammatory hyperalgesia. Eur J Pharmacol. 1987 Mar 17;135(2):145–153. [PubMed]
  • Poole S, Bristow AF, Selkirk S, Rafferty B. Development and application of radioimmunoassays for interleukin-1 alpha and interleukin-1 beta. J Immunol Methods. 1989 Jan 17;116(2):259–264. [PubMed]
  • Rampart M, Van Damme J, Zonnekeyn L, Herman AG. Granulocyte chemotactic protein/interleukin-8 induces plasma leakage and neutrophil accumulation in rabbit skin. Am J Pathol. 1989 Jul;135(1):21–25. [PMC free article] [PubMed]
  • Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232–235. [PubMed]
  • Westwick J, Li SW, Camp RD. Novel neutrophil-stimulating peptides. Immunol Today. 1989 May;10(5):146–147. [PubMed]

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