Table 1
Sensitivity, Specificity, and Biochemical Recurrence-Free Survival (BRFS) Probabilities for Definitions of Biochemical Failure Among Patients Treated With External-Beam Radiation Monotherapy
| 5-Year | 10-Year | |||
|---|---|---|---|---|
| Definition | Sensitivity (%)* | Specificity (%)* | BRFS (%) | BRFS (%) |
| ASTRO (1997) | 61 | 80 | 59 | 49 |
| Nadir + 2 | 74 | 82 | 68 | 44 |
| PSA > 0.2 ng/mL | 91 | 9 | 15 | 3 |
*Performance characteristics with respect to the ability of the definition to predict subsequent clinical failure (local failure, distant failure, institution of hormonal therapy, and post-treatment PSA > 25 ng/mL).
Adapted from Kuban D et al.10