# Network structure of cerebral cortex shapes functional connectivity on multiple time scales

^{†}Department of Cognitive Neuroscience, Section of Neurophysiology and Neuroinformatics, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands;

^{‡}Cecile and Oskar Vogt Brain Research Institute and Institute of Anatomy II, Heinrich Heine University, Moorenstrasse 5, D-40225 Düsseldorf, Germany; and

^{§}School of Psychiatry, University of New South Wales, and The Black Dog Institute, Randwick NSW 2031, Australia

^{¶}To whom correspondence should be addressed. E-mail: ude.anaidni@snropso

Author contributions: C.J.H., R.K., M.B., and O.S. designed research; C.J.H. and O.S. performed research; C.J.H., R.K., M.B., and O.S. contributed new reagents/analytic tools; C.J.H. and O.S. analyzed data; and C.J.H., R.K., M.B., and O.S. wrote the paper.

## Abstract

Neuronal dynamics unfolding within the cerebral cortex exhibit complex spatial and temporal patterns even in the absence of external input. Here we use a computational approach in an attempt to relate these features of spontaneous cortical dynamics to the underlying anatomical connectivity. Simulating nonlinear neuronal dynamics on a network that captures the large-scale interregional connections of macaque neocortex, and applying information theoretic measures to identify functional networks, we find structure–function relations at multiple temporal scales. Functional networks recovered from long windows of neural activity (minutes) largely overlap with the underlying structural network. As a result, hubs in these long-run functional networks correspond to structural hubs. In contrast, significant fluctuations in functional topology are observed across the sequence of networks recovered from consecutive shorter (seconds) time windows. The functional centrality of individual nodes varies across time as interregional couplings shift. Furthermore, the transient couplings between brain regions are coordinated in a manner that reveals the existence of two anticorrelated clusters. These clusters are linked by prefrontal and parietal regions that are hub nodes in the underlying structural network. At an even faster time scale (hundreds of milliseconds) we detect individual episodes of interregional phase-locking and find that slow variations in the statistics of these transient episodes, contingent on the underlying anatomical structure, produce the transfer entropy functional connectivity and simulated blood oxygenation level-dependent correlation patterns observed on slower time scales.

**Keywords:**functional MRI, graph theory, neuroanatomy, synchrony

The anatomical connections between regions of the cerebral cortex form a structural network upon which neural activity unfolds. Cortical regions dynamically couple to one another forming functional networks associated with perception, cognition, and action (1–4), as well as during spontaneous activity in the default or resting state (5–12). Functional networks extracted from higher-frequency dynamics (≈10 Hz) undergo rapid reconfiguration, e.g., in perceptual binding (13) or sensorimotor coordination (14). Functional networks extracted from lower-frequency (<0.1 Hz) spontaneous cortical dynamics are organized into anticorrelated clusters (8, 10), and the transient activation of these clusters has been linked to attentional processes (10, 12). Recent analyses suggest that structural and functional brain networks share “small-world” topologies and hub nodes (15–20) and that structural and functional clusters may closely correspond (21, 22). Nevertheless, it remains unclear how functional networks at different time scales relate to one another and to their common structural substrate.

Here we studied mappings between structural and functional networks using a computational approach. A structural network of segregated regions and interregional pathways was obtained from anatomical studies of macaque cortex and collated using the neuroinformatics tool CoCoMac (23). We then simulated the mean activation of each brain region within this network using a nonlinear model of spontaneous neuronal activity (24). From these activity patterns we built maps of interregional interaction by measuring transfer entropy (TE) [a measure designed to capture patterns of directed interaction and information flow (25)], in long (minutes) and intermediate (seconds) data samples. Our most fine-grained temporal measure is the phase locking value (26), which can identify transient synchrony between region pairs on the millisecond scale. For all methods we thresholded the regional interaction maps to produce functional networks whose topologies can be compared with one another and with that of the underlying structural network.

Node centrality is a useful diagnostic for comparing topologies, and so we first identified structural hubs using network measures based on local flow, global centrality, and motif distributions. After constructing functional networks, we found temporally varying network structure at multiple time scales. Using long data samples, TE yields the closest match between structural and functional connections including a close correspondence between structural and functional hubs. On a time scale of seconds, we found that functional networks exhibit significant fluctuations. These fluctuations reflect slow variations in the mean length and frequency of intermittent synchronous episodes. These slow variations, both in functional connectivity and in values of estimated regional blood oxygenation level-dependent (BOLD) signal, were coordinated via anatomical connection patterns, and we defined two major anticorrelated functional clusters. Our model suggests that the cortical resting state is not time-invariant, but instead contains rich and interrelated temporal structure at multiple time scales that is shaped by the underlying structural topology.

## Results

### Identification of Structural Hubs.

All analyses and simulations were carried out using a connection matrix of macaque neocortex, comprising 47 visual, sensory, and motor areas linked by 505 pathways previously identified by anatomical tracing studies (Fig. 1*A*). Hubs in brain networks allow for increased levels of information flow between otherwise distant or disconnected nodes, acting as connectors or integrators at central locations within the network. Because all of the hub identification tools we employ depend on the degree distribution of the network, we performed statistical comparisons to degree-matched random and lattice networks using *z*-scores on a node-by-node basis [see supporting information (SI)]. To estimate the capacity of a node to conduct information flow between its neighboring nodes, we introduced the flow coefficient, a measure of “local centrality” (see SI). It is calculated as the number of actual paths of length 2 divided by the number of all possible paths of length 2 that traverse a central node. Hub regions that act as bridges between different communities of nodes are likely to exhibit small clustering coefficients (16) and large flow coefficients. In macaque neocortex, areas V4, 46, 7a, STPp, and TH (Fig. 1*B*) are among those with flow-clustering ratios at levels that are significantly increased relative to degree-matched random controls. Betweenness centrality (Fig. 1*C*) is a more global centrality measure that captures the tendency of a node to lie along the shortest path between pairs of nodes in the network (27). In macaque neocortex, areas V4, 5, 46, TF, 7b, and SII are among those areas with significantly elevated betweenness centrality. Structural motifs (28, 29) provide a complementary means of identifying hubs. In large-scale cortical networks, structural hubs will tend to be reciprocally linked to brain regions that are not directly connected to one another; i.e., they tend to participate in motifs consisting of exactly two reciprocal edges (see Fig. 1*D Inset*). Fig. 1*E* shows the motif participation profiles for individual brain regions in macaque neocortex. Areas V4, 46, 7a, STPp, 7b, FST, TE, MSTd, Ig, DP, and VP show significantly increased motif contributions. Reviewing the results of flow centrality, betweenness centrality, and motif approaches to hub identification, we see that only area V4 emerges as highly ranked across all three measures (Fig. 1 *B–D*) whereas areas 46, 7a, 7b, and STPp show significance in at least two of these three measures.

### Simulation of Neuronal Dynamics.

To emulate neuronal dynamics within the macaque neocortex we implemented a neural mass model adopted from a conductance-based model of neuronal dynamics (30) for local population activity (31). Units of the model describe local populations of densely interconnected inhibitory and excitatory neurons whose behaviors are determined by voltage- and ligand-gated membrane channels. Sodium and calcium channels display a nonlinear sigmoid-shaped graph of voltage-dependent conductance. Potassium channel conductance is modeled in a more complex manner, exponentially relaxing toward its voltage-dependent state. A medium-scale (mesoscopic) array is then constructed from these local nonlinear populations by introducing long-range pyramidal connections, mimicking glutamate-induced synaptic currents (24, 32). Activity in the system arises purely from nonlinear instabilities. Oscillations are hence spontaneous and self organizing. Spatiotemporal patterns arise through reentrant excitatory–excitatory feedback. In the present case we used the macaque neocortical connectivity to determine the internode coupling. We chose parameter settings that replicate realistic conductances and have previously been reported to show complex, spontaneous activity, including intermittency, phase synchrony, and marginal stability (24, 32). Internode coupling was set to a low value (*c* = 0.1) at which synchronous dynamics are weakly stable, allowing spontaneous switching between synchronous epochs and desynchronous bursts (32). Under this parameterization the neural interactions in the model reflect a shifting balance between the effects of the structural substrate and of spontaneously arising “self-organizing” patterns that are uninfluenced by task- or input-related factors. The model is described in detail in the SI.

### Functional Connectivity at Multiple Time Scales.

Functional connectivity is defined as the statistical dependence between remote neural processes (33). Here we identified functional connections by using TE (25), an asymmetric information theoretic measure designed to capture directed information flow. We first applied it to long samples of time series data (240,000 time steps; 240 sec). TE values were thresholded to produce binary functional networks (see Fig. 2*A*). The threshold was chosen such that the total number of connections in a functional network is equal to the number of structural connections. Using long data samples, TE networks and structural networks showed up to 80% overlap, whereas the overlap between structural networks and functional networks extracted with mutual information and wavelet-based tools was lower (see SI).

*A*) Example of a functional TE network, calculated using a 240,000 time step data segment (240 sec). The functional matrix has been thresholded to yield a binary network with connection density equal to

**...**

We carried out a detailed analysis of structure–function correspondence for several topological measures (see SI). The degrees, flow coefficients, and centrality of nodes within TE networks are strongly correlated with those of nodes within the structural network. For example, betweenness centrality of individual nodes is highly correlated between structural and TE matrices (*r*^{2} = 0.78; see Fig. 2*B*). Weaker correlations for centrality are observed when functional networks are constructed by using mutual information or wavelet methods (*r*^{2} = 0.58 and *r*^{2} = 0.53, respectively). This suggests that many of the functional hubs identified in neuroimaging studies (18) are likely to be structural hubs as well.

TE matrices computed over large data samples reveal, on average, very close relations between the functional and structural characteristics of brain regions. However, analyses using overlapping time intervals that are shorter while still allowing for unbiased entropy estimation (30,000 time steps; 30 sec with a 6-sec shift between windows) reveal TE patterns as dynamic and time-dependent, indicating gradual reconfiguration of functional connections. These fluctuations occur despite the fact that the underlying structural connections are of constant strength and reflect the marginally stable and itinerant nature of the neuronal dynamics. Fig. 2*C* shows the variation over time in the mean magnitude of network interactions.

Temporal variations in interaction strength produce changes in the topology of functional networks and thus in the functional centrality of each node. Fig. 2*D* shows betweenness centrality across time, and also in relation to node degree, for selected areas in the network. For regions that, over longer time periods (see Fig. 2*B*), exhibit hub characteristics (e.g., areas V4 and 46), analyses over shorter time scales reveal substantial variations in degree and betweenness centrality over wide ranges. The centrality of highly connected non-hub regions (e.g., area V1) remains low. Hence under spontaneous nonlinear dynamics hubs engage and disengage across time (“hub dynamics”).

As patterns of functional connections change, network nodes gain and lose functional connections (i.e., change degree). Cross-regional correlations in degree across time reveal the existence of functional clusters that coordinate their intra- and inter-group interactions. Fig. 3*A* shows the pattern of such correlations obtained for TE networks (average of four simulations), characterized by the presence of two main clusters. One of these clusters contains mostly visual areas, particularly those of the ventral stream, whereas the other contains somatosensory and motor areas as well as portions of the dorsal visual stream. Both clusters consist of brain regions that are largely contiguous on the cortical surface, with one cluster restricted mostly to the occipital and temporal lobes while the other occupies portions of the parietal and frontal lobes (Fig. 3*B*). Several areas (e.g., parietal area 7a and frontal area 46), although initially grouped with the occipitotemporal cluster, maintain equally strong correlations with members in both clusters, rendering them “intermediate” articulation points that link the two clusters (see also ref. 22). Degree correlations are the result of slow fluctuations in mean TE for the two clusters (Fig. 3*C*) reflecting alternating periods of elevated information flow within each of the two clusters. In control runs with randomized connection matrices (preserving the in- and out-degree of each node but eliminating the large-scale clustered architecture of the original matrix) we found that, although regional TE fluctuations persisted, between-cluster differences were greatly reduced (Fig. 3*D*), indicating that clustering in large-scale structural connections is crucial for the generation of large-scale functional anti-correlations within our model.

### BOLD Correlations and Synchrony.

To more closely relate these patterns of functional connectivity to recent neuroimaging work (8, 10, 11) we used the observed changes in membrane potential across time in each brain region, in conjunction with a Balloon–Windkessel hemodynamic model (48–50), to estimate a BOLD signal for each region. After regressing out global BOLD fluctuations (as in ref. 10), pairwise cross-correlations between the residual regional signals again reveal two anticorrelated clusters (Fig. 4 *A* and *B*) that correspond closely to those identified on the basis of TE functional connectivity (Fig. 3 *A* and *B*).

*A*) BOLD correlation matrix, computed from estimated BOLD time series after regressing out global BOLD fluctuations and sampled every 2 sec. Matrix represents an average over four 960,000 time step runs

**...**

Further investigation reveals that BOLD signal and functional connectivity fluctuations occurring over many seconds are related to one another (Fig. 4*C*) as well as to the fast synchronization dynamics of the system (Fig. 4*D*). Synchronous (phase-locked) episodes are first identified by calculating the instantaneous phase difference between the oscillatory dynamics at each node using the phase locking value (26). In our model (see SI), as in other weakly coupled systems (34), phase differences are most commonly found to be near 0 radians (in-phase synchronization) or π radians (anti-phase synchronization). Episodes of synchronization typically last between 50 and 300 msec (see SI), a time scale that is consistent with experimental observations of transient synchronous networks *in vivo* (3). The total length of all synchronous episodes within a given 30-sec time window is correlated (see SI) with the aggregate TE observed in the network across that period, as well as with the mean BOLD signal across regions (Fig. 4*D*; *r*^{2} = 0.55). Examining BOLD synchrony relations region by region we find that, across consecutive 2-sec time windows, BOLD signal amplitudes are correlated with the time each region spends in synchrony. These correlations are strongest for high-degree nodes (see SI). The relationship is lagged by 2–4 sec because of hemodynamic delays (Fig. 4*E*).

Functional connectivity, BOLD signal amplitude, and the propensity to synchronize are thus interrelated within our model. The fluctuations in functional connectivity and in BOLD signal that we observe on a slow time scale (≈0.1 Hz) are a result of fluctuations in the aggregate number of transient couplings and decouplings occurring on a far more rapid time scale (≈10 Hz). Region pairs engaged in long synchronous episodes at a consistent phase tend to be strongly functionally connected (with high TE), and their BOLD signals tend to be elevated.

## Discussion

Simulating neuronal dynamics on a network of large-scale interregional connections in the macaque cortex allowed us to investigate functional connectivity patterns at multiple time scales and to relate them to one another and to their structural substrate. Fast neuronal dynamics exhibit intermittent synchronization and desynchronization on a time scale of hundreds of milliseconds, enabling the system to continually explore a repertoire of functional microstates (35). Slow variations in the statistics of synchronous coupling give rise to changes in the strength of directed interactions between regions on a time scale of seconds. Our model suggests that spontaneous cortical dynamics exhibit ongoing changes in the pattern and strengths of functional coupling and that these coupling events are in turn related to BOLD signal amplitude. The cortical resting state thus exhibits rich and interrelated spatiotemporal structure at multiple scales.

At the slowest time scale (minutes of data) we find that the aggregate strength of functional couplings between regions is, on average, a good indicator of the presence of an underlying structural link. Thresholded functional networks calculated over long time windows closely matched the original structural connection matrix (Fig. 1*A*), with 79% of the true anatomical links being recovered from the TE analysis (Fig. 2*A* and SI) along with several features of global topology such as centrality. The success of the TE approach in matching anatomical connections can be attributed to two factors: (*i*) its sensitivity to directed (nonreciprocal) interactions and (*ii*) the ergodicity of the chaotic neuronal dynamics, which allows the high-dimensional probability densities required for the calculation of TE to be well estimated from long time windows.

At an intermediate time scale (6-sec intervals, ≈0.1 Hz) significant fluctuations were observed in the strengths of functional coupling. These fluctuations were correlated in time across regions (Fig. 3), with regions participating in one of two functional clusters. Furthermore, the same anticorrelated functional clusters were found when analyzing BOLD signal time series estimated from regional activity (Fig. 4). One cluster comprises mostly visual regions located in the occipital and temporal lobes whereas the other cluster contains mainly somatomotor and frontal regions. Some regions of high structural centrality [notably areas 46, 7a, 7b, and STPp, previously labeled “associational areas” (36)] participated in both clusters, whereas others (e.g., V4 and SII) occupied central positions within their respective clusters.

At the fastest time scale analyzed (≈10 Hz) we observed intermittent synchronization and desynchronization between brain regions. Signals were typically locked at 0 or π radians phase difference for between 50 and 300 msec. At weak interregional coupling, global synchronization never occurs. Instead the system's dynamics consists of a very large set of metastable states similar to what is observed in other classes of high-dimensional chaos [e.g., chaotic itinerancy (37)] that exhibit multiscale temporal structure (38).

The link between fluctuations in transfer entropy and, at a similar time scale, in resting-state fMRI time-series appears to be mediated by the relationship between the synchronization of neuronal dynamics and the mean activity of neuronal populations. This observation is consistent with recent simulations (39), which showed that increased synchronization cannot be divorced from increases in mean firing-rate. Importantly, it suggests that empirical fMRI signals may reflect the time-varying fast synchronization of population dynamics.

Our model currently does not incorporate any time variation in sensory inputs or in the efficacy of anatomical links, and yet we find spontaneous neuronal dynamics that are structured at multiple time scales. The model therefore suggests that the combination of fast and intermittently synchronizing neuronal dynamics and a clustered anatomical substrate may account for two recently observed phenomena: (*i*) large-scale organization and the existence of hubs in functional connectivity networks (17–20) and (*ii*) functional clusters that are anticorrelated on a time scale of seconds (8, 10) and possibly bridged (10) via areas in parietal cortex (e.g., area 7a) and frontal cortex (e.g., area 46). On the basis of the model, we predict that individual differences in the strength and location of resting state functional clusters will correlate strongly with individual differences in the topology and efficacy of large-scale corticocortical pathways now detectable using neuroimaging technologies (40).

## Methods

### Connection Data Set.

We examine a large-scale anatomical data set, referred to in this article as “macaque neocortex,” consisting of a binary connection matrix of brain regions (listed in SI) connected by interregional pathways. Macaque neocortex (Fig. 1*A*) is an updated network matrix generated following the parcellation scheme of Felleman and Van Essen (36), including visual, somatosensory and motor cortical regions as well as their interconnections (which had not been included previously). The data were manually collated in the CoCoMac database from published tracing studies according to standard procedures (23, 41). Subsequently, all relevant data were translated algorithmically to the Felleman and Van Essen map using coordinate-independent mapping (42, 43). After resolution of redundant and inconsistent results a binary connection matrix with *n* = 47 nodes (vertices) and *K* = 505 edges (connections) was generated.

### Graph Theory Methods.

All graph-theoretic analyses were conducted on binary matrices. Where necessary, weighted matrices were binarized by thresholding in such a manner as to maintain a constant connection density across networks. The clustering coefficient of a node (15) is calculated as the number of all existing connections between the node's neighbors divided by the number of all possible such connections. In analogy to the clustering coefficient, we define the flow coefficient as the number of all paths of length 2 linking neighbors of a central node that pass through the node, divided by the total number of all possible such paths (see SI).

Central nodes in a network are those that have structural or functional importance, for example, by serving as way stations for network traffic (analogous to bridges or connectors) or by influencing many other nodes via short paths (Fig. 1*C*). The betweenness centrality of a node is defined as the fraction of shortest paths between all pairs of nodes that travel through that node (27) and was calculated here by using algorithms developed by D. Gleich (www.stanford.edu/~dgleich/programs/matlab_bgl; ref. 44).

Structural motifs (subgraphs) of size *M* consist of *M* nodes and a set of edges (maximally *M*^{2} − *M*, for directed graphs, minimally *M* − *1* with connectedness ensured). In this study we analyzed macaque neocortex for motifs of size *M* = 3 (Fig. 1*D*).

Statistical evaluation of our results requires the design of appropriate null models (45). Such models are not uniquely defined, as statistical comparisons may be carried out relative to many different random models that preserve particular subsets of structural parameters. In this study we generated populations of control (“random”) networks (*n* = 1,000) using a Markov switching algorithm that preserves degree sequences (46). Lattice networks used as additional controls for data shown in Fig. 1*D* were created as previously described (16).

### TE.

TE was estimated (47) from Gaussian-resampled time series (see SI) discretized into one of 32 bins of uniform width. Sampling bias was corrected by subtraction of a baseline value for each node pair. The baseline for each pair was equal to the TE value obtained from time-shifted data, at a single shift of 4,000 time steps or averaging over shifts of 3,000, 3,500, 4,000, 4,500 and 5,000 time steps (see SI).

TE (25) quantifies the deviation from the generalized Markov property: *p*(*x _{t+1}*|

*x*) =

_{t}*p*(

*x*|

_{t+1}*x*,

_{t}*y*) where

_{t}*x*is the bin assignment of time series

_{t}*x*at time

*t*. If conditioning on

*Y**alters the transition probabilities of*

_{t}

*X**, then the assumption of a Markov process is invalid. The incorrectness of the assumption is expressed by the TE, formulated as the Kullback–Leibler entropy:*

_{t} where the index ** Y** →

**indicates the influence of**

*X***on**

*Y***. TE is nonsymmetric and can thus detect the directed exchange of information (e.g., information flow or causal influence) between**

*X**x*and

*y*.

### BOLD Signal Estimation.

Closely following ref. 48 in employing the Balloon–Windkessel hemodynamic model (49, 50), we estimated a BOLD signal for each region based on the local neuronal activity output by our neural mass model. The estimated BOLD signal was calculated independently for each region, disregarding potential effects due to blood flow between spatially adjacent brain regions. Equations and parameters relating neuronal activity and vasodilatory signal with blood inflow, volume, and deoxyhemoglobin content are taken directly from ref. 48. The main model input, “neuronal activity,” is taken to be the absolute value of the time derivative of the mean excitatory membrane potential within each brain region (glutamate turnover).

## Acknowledgments

We thank S. Newman, R. McIntosh, L. Pessoa, G. Tononi, and A. Vespignani for helpful comments and J. Roberts for technical assistance with BOLD modeling. R.K. acknowledges support by the Deutsche Forschungsgemeinschaft (KO 1560/6-2). C.J.H., R.K., M.B., and O.S. were supported by the J. S. McDonnell Foundation.

## Abbreviations

- TE
- transfer entropy
- BOLD
- blood oxygenation level-dependent.

## Footnotes

The authors declare no conflict of interest.

This article is a PNAS Direct Submission.

This article contains supporting information online at www.pnas.org/cgi/content/full/0701519104/DC1.

## References

*MatlabBGL*. Stanford, CA: Stanford University Institute for Computational and Mathematical Engineering; 2006. Version 1.01.

**National Academy of Sciences**

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- Theoretical neuroanatomy and the connectivity of the cerebral cortex.[Behav Brain Res. 2002]
*Sporns O, Tononi G, Edelman GM.**Behav Brain Res. 2002 Sep 20; 135(1-2):69-74.* - Rich club organization of macaque cerebral cortex and its role in network communication.[PLoS One. 2012]
*Harriger L, van den Heuvel MP, Sporns O.**PLoS One. 2012; 7(9):e46497. Epub 2012 Sep 28.* - Functional connectivity as revealed by spatial independent component analysis of fMRI measurements during rest.[Hum Brain Mapp. 2004]
*van de Ven VG, Formisano E, Prvulovic D, Roeder CH, Linden DE.**Hum Brain Mapp. 2004 Jul; 22(3):165-78.* - Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex.[Brain Struct Funct. 2007]
*Lübke J, Feldmeyer D.**Brain Struct Funct. 2007 Jul; 212(1):3-17. Epub 2007 Jun 1.* - Dynamic functional connectivity.[Curr Opin Neurobiol. 2007]
*Ioannides AA.**Curr Opin Neurobiol. 2007 Apr; 17(2):161-70. Epub 2007 Mar 26.*

- From Connectivity Models to Region Labels: Identifying Foci of a Neurological Disorder[IEEE transactions on medical imaging. 2013]
*Venkataraman A, Kubicki M, Golland P.**IEEE transactions on medical imaging. 2013 Nov; 32(11)2078-2098* - Multiplex Networks of Cortical and Hippocampal Neurons Revealed at Different Timescales[PLoS ONE. ]
*Timme N, Ito S, Myroshnychenko M, Yeh FC, Hiolski E, Hottowy P, Beggs JM.**PLoS ONE. 9(12)e115764* - Frequency-specific network topologies in the resting human brain[Frontiers in Human Neuroscience. ]
*Sasai S, Homae F, Watanabe H, Sasaki AT, Tanabe HC, Sadato N, Taga G.**Frontiers in Human Neuroscience. 81022* - Functional network alterations and their structural substrate in drug-resistant epilepsy[Frontiers in Neuroscience. ]
*Caciagli L, Bernhardt BC, Hong SJ, Bernasconi A, Bernasconi N.**Frontiers in Neuroscience. 8411* - Zero-Lag Synchronization Despite Inhomogeneities in a Relay System[PLoS ONE. ]
*Ghasemi Esfahani Z, Valizadeh A.**PLoS ONE. 9(12)e112688*

- PubMedPubMedPubMed citations for these articles

- Network structure of cerebral cortex shapes functional connectivity on multiple ...Network structure of cerebral cortex shapes functional connectivity on multiple time scalesProceedings of the National Academy of Sciences of the United States of America. 2007 Jun 12; 104(24)10240

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