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Am J Pathol. Aug 1989; 135(2): 281–289.
PMCID: PMC1879924

Malignant lymphoma of the gastrointestinal tract and mesentery. A clinico-pathologic study of the significance of histologic classification. NHL Study Group of the Comprehensive Cancer Center West.

Abstract

A series of 92 malignant lymphomas of the gastrointestinal tract and mesentery obtained from a population-based registry was studied to assess whether the newly defined concept of mucosa-associated lymphoma has clinical relevance. The cases were grouped according to localization; gastric, intestinal, and mesenteric lymphoma. All cases were reviewed histologically, graded according to the Working Formulation, and reclassified according to the Kiel classification, which was modified to include the categories low- and high-grade mucosa-associated lymphoma. Clinical data, as well as staging and follow-up data, were related to both the original diagnosis and the diagnosis after reclassification. The results showed that the distribution of the types of lymphoma is related to site: centroblastic lymphoma was predominant in the stomach, lymphoblastic in the bowel, and follicular centroblastic-centrocytic in the mesentery. Gastrointestinal lymphoma was disseminated in approximately 50% of the patients at presentation. Survival analysis revealed that classification according to the original Kiel classification and grading according to the Working Formulation provided important prognostic information, whereas introduction of mucosa-associated lymphoma as an entity did not. It was concluded that modification of current classifications to include a separate category for mucosa-associated lymphoma is not useful.

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  • Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer. 1972 Jan;29(1):252–260. [PubMed]
  • Vanden Heule B, Van Kerkem C, Heimann R. Benign and malignant lymphoid lesions of the stomach. A histological reappraisal in the light of the Kiel classification for non-Hodgkin's lymphomas. Histopathology. 1979 Jul;3(4):309–320. [PubMed]
  • Otto HF, Bettmann I, Weltzien JV, Gebbers JO. Primary intestinal lymphomas. Virchows Arch A Pathol Anat Histol. 1981;391(1):9–31. [PubMed]
  • Saraga P, Hurlimann J, Ozzello L. Lymphomas and pseudolymphomas of the alimentary tract. An immunohistochemical study with clinicopathologic correlations. Hum Pathol. 1981 Aug;12(8):713–723. [PubMed]
  • Seo IS, Binkley WB, Warner TF, Warfel KA. A combined morphologic and immunologic approach to the diagnosis of gastrointestinal lymphomas: I. Malignant lymphoma of the stomach (a clinicopathologic study of 22 cases). Cancer. 1982 Feb 1;49(3):493–501. [PubMed]
  • Weingrad DN, Decosse JJ, Sherlock P, Straus D, Lieberman PH, Filippa DA. Primary gastrointestinal lymphoma: a 30-year review. Cancer. 1982 Mar 15;49(6):1258–1265. [PubMed]
  • Knowles DM, 2nd, Halper JP, Jakobiec FA. The immunologic characterization of 40 extranodal lymphoid infiltrates: usefulness in distinguishing between benign pseudolymphoma and malignant lymphoma. Cancer. 1982 Jun 1;49(11):2321–2335. [PubMed]
  • Brooks JJ, Enterline HT. Gastric pseudolymphoma. Its three subtypes and relation to lymphoma. Cancer. 1983 Feb 1;51(3):476–486. [PubMed]
  • Brooks JJ, Enterline HT. Primary gastric lymphomas. A clinicopathologic study of 58 cases with long-term follow-up and literature review. Cancer. 1983 Feb 15;51(4):701–711. [PubMed]
  • Filippa DA, Lieberman PH, Weingrad DN, Decosse JJ, Bretsky SS. Primary lymphomas of the gastrointestinal tract. Analysis of prognostic factors with emphasis on histological type. Am J Surg Pathol. 1983 Jun;7(4):363–372. [PubMed]
  • Sandler RS. Primary gastric lymphoma: a review. Am J Gastroenterol. 1984 Jan;79(1):21–25. [PubMed]
  • Dragosics B, Bauer P, Radaszkiewicz T. Primary gastrointestinal non-Hodgkin's lymphomas. A retrospective clinicopathologic study of 150 cases. Cancer. 1985 Mar 1;55(5):1060–1073. [PubMed]
  • Grody WW, Magidson JG, Weiss LM, Hu E, Warnke HA, Lewin KJ. Gastrointestinal lymphomas. Immunohistochemical studies on the cell of origin. Am J Surg Pathol. 1985 May;9(5):328–337. [PubMed]
  • Mohri N. Primary gastric non-Hodgkin's lymphomas in Japan. Virchows Arch A Pathol Anat Histopathol. 1987;411(5):459–466. [PubMed]
  • Joensuu H, Söderström KO, Klemi PJ, Eerola E. Nuclear DNA content and its prognostic value in lymphoma of the stomach. Cancer. 1987 Dec 15;60(12):3042–3048. [PubMed]
  • Burke JS, Sheibani K, Nathwani BN, Winberg CD, Rappaport H. Monoclonal small (well-differentiated) lymphocytic proliferations of the gastrointestinal tract resembling lymphoid hyperplasia: a neoplasm of uncertain malignant potential. Hum Pathol. 1987 Dec;18(12):1238–1245. [PubMed]
  • Isaacson PG, Spencer J. Malignant lymphoma of mucosa-associated lymphoid tissue. Histopathology. 1987 May;11(5):445–462. [PubMed]
  • Shepherd NA, Hall PA, Coates PJ, Levison DA. Primary malignant lymphoma of the colon and rectum. A histopathological and immunohistochemical analysis of 45 cases with clinicopathological correlations. Histopathology. 1988 Mar;12(3):235–252. [PubMed]
  • Isaacson P, Wright DH. Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer. 1983 Oct 15;52(8):1410–1416. [PubMed]
  • Isaacson P, Wright DH. Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue. Cancer. 1984 Jun 1;53(11):2515–2524. [PubMed]
  • Myhre MJ, Isaacson PG. Primary B-cell gastric lymphoma--a reassessment of its histogenesis. J Pathol. 1987 May;152(1):1–11. [PubMed]
  • Weisenburger DD, Nathwani BN, Diamond LW, Winberg CD, Rappaport H. Malignant lymphoma, intermediate lymphocytic type: a clinicopathologic study of 42 cases. Cancer. 1981 Sep 15;48(6):1415–1425. [PubMed]
  • van der Valk P, te Velde J, Jansen J, Ruiter DJ, Spaander PJ, Cornelisse CJ, Meijer CJ. Malignant lymphoma of true histiocytic origin: histiocytic sarcoma. A morphological, ultrastructural, immunological, cytochemical and clinical study of 10 cases. Virchows Arch A Pathol Anat Histol. 1981;391(3):249–265. [PubMed]
  • Lewin KJ, Ranchod M, Dorfman RF. Lymphomas of the gastrointestinal tract: a study of 117 cases presenting with gastrointestinal disease. Cancer. 1978 Aug;42(2):693–707. [PubMed]
  • Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M. Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res. 1971 Nov;31(11):1860–1861. [PubMed]
  • Musshoff K. Klinische Stadieneinteilung der Nicht-Hodgkin-Lymphome. Strahlentherapie. 1977 Apr;153(4):218–221. [PubMed]
  • Hui PK, Feller AC, Lennert K. High-grade non-Hodgkin's lymphoma of B-cell type. I. Histopathology. Histopathology. 1988 Feb;12(2):127–143. [PubMed]
  • Hernandez JA, Sheehan WW. Lymphomas of the mucosa-associated lymphoid tissue. Signet ring cell lymphomas presenting in mucosal lymphoid organs. Cancer. 1985 Feb 1;55(3):592–597. [PubMed]
  • Vimadalal SD, Said JW, Voyles H., 3rd Gastric lymphoreticular neoplasms: an immunologic study of 36 cases. Am J Clin Pathol. 1983 Dec;80(6):792–799. [PubMed]
  • Papadimitriou CS, Papacharalampous NX, Kittas C. Primary gastrointestinal malignant lymphomas. A morphologic and immunohistochemical study. Cancer. 1985 Feb 15;55(4):870–879. [PubMed]
  • Berger F, Coiffier B, Bonneville C, Scoazec JY, Magaud JP, Bryon PA. Gastrointestinal lymphomas. Immunohistologic study of 23 cases. Am J Clin Pathol. 1987 Dec;88(6):707–712. [PubMed]
  • Jasani B. Immunohistologically definable light chain restriction in autoimmune disease. J Pathol. 1988 Jan;154(1):1–5. [PubMed]
  • Bartl R, Hansmann ML, Frisch B, Burkhardt R. Comparative histology of malignant lymphomas in lymph node and bone marrow. Br J Haematol. 1988 Jun;69(2):229–237. [PubMed]
  • Addis BJ, Hyjek E, Isaacson PG. Primary pulmonary lymphoma: a re-appraisal of its histogenesis and its relationship to pseudolymphoma and lymphoid interstitial pneumonia. Histopathology. 1988 Jul;13(1):1–17. [PubMed]
  • Blackledge G, Bush H, Dodge OG, Crowther D. A study of gastro-intestinal lymphoma. Clin Oncol. 1979 Sep;5(3):209–219. [PubMed]
  • van Krieken JH, von Schilling C, Kluin PM, Lennert K. Splenic marginal zone lymphocytes and related cells in the lymph node: a morphologic and immunohistochemical study. Hum Pathol. 1989 Apr;20(4):320–325. [PubMed]

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