Logo of amjpatholAmerican Journal of Pathology For AuthorsAmerican Journal of Pathology SubscribeAmerican Journal of Pathology SearchAmerican Journal of Pathology Current IssueAmerican Journal of Pathology About the JournalAmerican Journal of Pathology
PMC full text:

Figure 1.

An external file that holds a picture, illustration, etc.
Object name is jh1091908001.jpg

Typical light microscopic aspect of a basaloid squamous cell carcinoma (BSCC) composed of cells with hyperchromatic nuclei and scant cyctoplasm (a); H&E; original magnification, ×400. Strong expression of Bcl-2 protein (brown cytoplasmatic reaction product) in an esophageal BSCC. Note the absence of Bcl-2 expression in the neighboring nonmalignant esophageal squamous epithelium (b); original magnification, ×400. Ethidium bromide-stained agarose gel of a differential PCR for the c-myc gene and the APRT gene in carcinoma tissues (Ca) and corresponding normal tissues (Normal) from 4 cases of esophageal BSCC. Note amplification of the c-myc gene in tumors 1 and 2, no c-myc amplification in tumors 3 and 4 (c).