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Figure 1.

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Typical light microscopic aspect of a basaloid squamous cell carcinoma (BSCC) composed of cells with hyperchromatic nuclei and scant cyctoplasm (a); H&E; original magnification, ×400. Strong expression of Bcl-2 protein (brown cytoplasmatic reaction product) in an esophageal BSCC. Note the absence of Bcl-2 expression in the neighboring nonmalignant esophageal squamous epithelium (b); original magnification, ×400. Ethidium bromide-stained agarose gel of a differential PCR for the c-myc gene and the APRT gene in carcinoma tissues (Ca) and corresponding normal tissues (Normal) from 4 cases of esophageal BSCC. Note amplification of the c-myc gene in tumors 1 and 2, no c-myc amplification in tumors 3 and 4 (c).