• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of amjpatholAmerican Journal of Pathology For AuthorsAmerican Journal of Pathology SubscribeAmerican Journal of Pathology SearchAmerican Journal of Pathology Current IssueAmerican Journal of Pathology About the JournalAmerican Journal of Pathology
Am J Pathol. Apr 1998; 152(4): 851–854.
PMCID: PMC1858255

Gap junction function: the messenger and the message.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (764K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Kumar NM, Gilula NB. The gap junction communication channel. Cell. 1996 Feb 9;84(3):381–388. [PubMed]
  • Bruzzone R, White TW, Goodenough DA. The cellular Internet: on-line with connexins. Bioessays. 1996 Sep;18(9):709–718. [PubMed]
  • Paul DL. Molecular cloning of cDNA for rat liver gap junction protein. J Cell Biol. 1986 Jul;103(1):123–134. [PMC free article] [PubMed]
  • Kumar NM, Gilula NB. Cloning and characterization of human and rat liver cDNAs coding for a gap junction protein. J Cell Biol. 1986 Sep;103(3):767–776. [PMC free article] [PubMed]
  • Beyer EC, Paul DL, Goodenough DA. Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J Cell Biol. 1987 Dec;105(6 Pt 1):2621–2629. [PMC free article] [PubMed]
  • Brink PR. Gap junction channel gating and permselectivity: their roles in co-ordinated tissue function. Clin Exp Pharmacol Physiol. 1996 Dec;23(12):1041–1046. [PubMed]
  • Spray DC. Molecular physiology of gap junction channels. Clin Exp Pharmacol Physiol. 1996 Dec;23(12):1038–1040. [PubMed]
  • Veenstra RD, Wang HZ, Beblo DA, Chilton MG, Harris AL, Beyer EC, Brink PR. Selectivity of connexin-specific gap junctions does not correlate with channel conductance. Circ Res. 1995 Dec;77(6):1156–1165. [PubMed]
  • Koval M, Geist ST, Westphale EM, Kemendy AE, Civitelli R, Beyer EC, Steinberg TH. Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43. J Cell Biol. 1995 Aug;130(4):987–995. [PMC free article] [PubMed]
  • Cao F, Eckert R, Elfgang C, Nitsche JM, Snyder SA, H-ulser DF, Willecke K, Nicholson BJ. A quantitative analysis of connexin-specific permeability differences of gap junctions expressed in HeLa transfectants and Xenopus oocytes. J Cell Sci. 1998 Jan;111(Pt 1):31–43. [PubMed]
  • Elfgang C, Eckert R, Lichtenberg-Fraté H, Butterweck A, Traub O, Klein RA, Hülser DF, Willecke K. Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells. J Cell Biol. 1995 May;129(3):805–817. [PMC free article] [PubMed]
  • Werner R, Levine E, Rabadan-Diehl C, Dahl G. Formation of hybrid cell-cell channels. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5380–5384. [PMC free article] [PubMed]
  • White TW, Bruzzone R, Goodenough DA, Paul DL. Voltage gating of connexins. Nature. 1994 Sep 15;371(6494):208–209. [PubMed]
  • Jiang JX, Goodenough DA. Heteromeric connexons in lens gap junction channels. Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1287–1291. [PMC free article] [PubMed]
  • Stauffer KA. The gap junction proteins beta 1-connexin (connexin-32) and beta 2-connexin (connexin-26) can form heteromeric hemichannels. J Biol Chem. 1995 Mar 24;270(12):6768–6772. [PubMed]
  • Brink PR, Cronin K, Banach K, Peterson E, Westphale EM, Seul KH, Ramanan SV, Beyer EC. Evidence for heteromeric gap junction channels formed from rat connexin43 and human connexin37. Am J Physiol. 1997 Oct;273(4 Pt 1):C1386–C1396. [PubMed]
  • Reaume AG, de Sousa PA, Kulkarni S, Langille BL, Zhu D, Davies TC, Juneja SC, Kidder GM, Rossant J. Cardiac malformation in neonatal mice lacking connexin43. Science. 1995 Mar 24;267(5205):1831–1834. [PubMed]
  • Simon AM, Goodenough DA, Li E, Paul DL. Female infertility in mice lacking connexin 37. Nature. 1997 Feb 6;385(6616):525–529. [PubMed]
  • Nelles E, Bützler C, Jung D, Temme A, Gabriel HD, Dahl U, Traub O, Stümpel F, Jungermann K, Zielasek J, et al. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9565–9570. [PMC free article] [PubMed]
  • Temme A, Buchmann A, Gabriel HD, Nelles E, Schwarz M, Willecke K. High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32. Curr Biol. 1997 Sep 1;7(9):713–716. [PubMed]
  • Gong X, Li E, Klier G, Huang Q, Wu Y, Lei H, Kumar NM, Horwitz J, Gilula NB. Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in mice. Cell. 1997 Dec 12;91(6):833–843. [PubMed]
  • Bergoffen J, Scherer SS, Wang S, Scott MO, Bone LJ, Paul DL, Chen K, Lensch MW, Chance PF, Fischbeck KH. Connexin mutations in X-linked Charcot-Marie-Tooth disease. Science. 1993 Dec 24;262(5142):2039–2042. [PubMed]
  • Krenacs T, Rosendaal M. Connexin43 gap junctions in normal, regenerating, and cultured mouse bone marrow and in human leukemias: their possible involvement in blood formation. Am J Pathol. 1998 Apr;152(4):993–1004. [PMC free article] [PubMed]
  • Campbell FR. Gap junctions between cells of bone marrow: an ultrastructural study using tannic acid. Anat Rec. 1980 Jan;196(1):101–107. [PubMed]
  • Dorshkind K, Green L, Godwin A, Fletcher WH. Connexin-43-type gap junctions mediate communication between bone marrow stromal cells. Blood. 1993 Jul 1;82(1):38–45. [PubMed]
  • Meda P. Gap junction involvement in secretion: the pancreas experience. Clin Exp Pharmacol Physiol. 1996 Dec;23(12):1053–1057. [PubMed]
  • Hobbie L, Kingsley DM, Kozarsky KF, Jackman RW, Krieger M. Restoration of LDL receptor activity in mutant cells by intercellular junctional communication. Science. 1987 Jan 2;235(4784):69–73. [PubMed]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology


Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...


  • PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...