|
|
Antimicrob Agents Chemother. 1984 May; 25(5): 626–629. | PMCID: PMC185601 |
Single-dose amoxicillin therapy of acute uncomplicated urinary tract infections in women. N E Tolkoff-Rubin, M E Wilson, P Zuromskis, I Jacoby, A R Martin, and R H Rubin Abstract Of 210 women who were experiencing dysuria, frequent urination, pyuria, and significant bacteriuria and who were treated with a single 3-g dose of amoxicillin, 165 (79%) were cured of their original infections. Patients with infections that were negative by antibody-coated-bacteria assay were cured at a significantly higher rate than those with infections that were positive by antibody-coated-bacteria assay (90 versus 59%; P less than 0.001). Similarly, those with infections caused by amoxicillin-susceptible organisms were cured at a significantly higher rate than those with infections caused by resistant organisms (85 versus 50%; P less than 0.001). Of 27 patients who had infections caused by amoxicillin-susceptible organisms and who had relapses after single-dose therapy, 14 (52%) had relapses again after a conventional 10-day course of therapy, although all responded to a 6-week course. An additional 27 patients experiencing dysuria, frequent urination, and pyuria but who had a lower number of uropathogens in the urine (10(2) to 10(4.5)/ml of urine) were treated with single-dose therapy, with a 100% eradication of organisms and an 89% rate of symptomatic relief. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (866K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Bailey RR, Abbott GD. Treatment of urinary-tract infection with a single dose of amoxycillin. Nephron. 1977;18(6):316–320. [PubMed]
- Bailey RR, Abbott GD. Treatment of urinary tract infection with a single dose of trimethoprim-sulfamethoxazole. Can Med Assoc J. 1978 Mar 4;118(5):551–552. [PubMed]
- Counts GW, Stamm WE, McKevitt M, Running K, Holmes KK, Turck M. Treatment of cystitis in women with a single dose of trimethoprim-sulfamethoxazole. Rev Infect Dis. 1982 Mar–Apr;4(2):484–490. [PubMed]
- Fang LS, Tolkoff-Rubin NE, Rubin RH. Efficacy of single-dose and conventional amoxicillin therapy in urinary-tract infection localized by the antibody-coated bacteria technic. N Engl J Med. 1978 Feb 23;298(8):413–416. [PubMed]
- Fang LS, Tolkoff-Rubin NE, Rubin RH. Localization and antibiotic management of urinary tract infection. Annu Rev Med. 1979;30:225–239. [PubMed]
- Källenius G, Winberg J. Urinary tract infections treated with single dose of short-acting sulphonamide. Br Med J. 1979 May 5;1(6172):1175–1176. [PubMed]
- Ronald AR, Boutros P, Mourtada H. Bacteriuria localization and response to single-dose therapy in women. JAMA. 1976 Apr 26;235(17):1854–1856. [PubMed]
- Rubin RH, Fang LS, Jones SR, Munford RS, Slepack JM, Varga PA, Onheiber L, Hall CL, Tolkoff-Rubin NE. Single-dose amoxicillin therapy for urinary tract infection. Multicenter trial using antibody-coated bacteria localization technique. JAMA. 1980 Aug 8;244(6):561–564. [PubMed]
- Sanford JP. Urinary tract symptoms and infections. Annu Rev Med. 1975;26:485–498. [PubMed]
- Savard-Fenton M, Fenton BW, Reller LB, Lauer BA, Byyny RL. Single-dose amoxicillin therapy with follow-up urine culture. Effective initial management for acute uncomplicated urinary tract infections. Am J Med. 1982 Dec;73(6):808–813. [PubMed]
- Smith PB, Tomfohrde KM, Rhoden DL, Balows A. API system: a multitube micromethod for identification of Enterobacteriaceae. Appl Microbiol. 1972 Sep;24(3):449–452. [PubMed]
- Stamm WE, Running K, McKevitt M, Counts GW, Turck M, Holmes KK. Treatment of the acute urethral syndrome. N Engl J Med. 1981 Apr 16;304(16):956–958. [PubMed]
- Stamm WE, Wagner KF, Amsel R, Alexander ER, Turck M, Counts GW, Holmes KK. Causes of the acute urethral syndrome in women. N Engl J Med. 1980 Aug 21;303(8):409–415. [PubMed]
- Thomas V, Shelokov A, Forland M. Antibody-coated bacteria in the urine and the site of urinary-tract infection. N Engl J Med. 1974 Mar 14;290(11):588–590. [PubMed]
- Tolkoff-Rubin NE, Weber D, Fang LS, Kelly M, Wilkinson R, Rubin RH. Single-dose therapy with trimethoprim-sulfamethoxazole for urinary tract infection in women. Rev Infect Dis. 1982 Mar–Apr;4(2):444–448. [PubMed]
|
This article has been