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Antimicrob Agents Chemother. May 1983; 23(5): 784–786.
PMCID: PMC184818

Transferable Resistance to Clindamycin, Erythromycin, and Tetracycline in Clostridium difficile

Abstract

Resistance to clindamycin, erythromycin, and streptogramins in Clostridium difficile could be transferred to a susceptible strain by mixed culture at low frequencies (1 × 10−8 to 4 − 10−8 per donor cell). Transfer of tetracycline resistance occurred at frequencies of 3 × 10−7 to 5 × 10−7. No plasmid DNA involved in these transfers could be detected.

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Selected References

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  • Bartlett JG. Antimicrobial agents implicated in Clostridium difficile toxin-associated diarrhea of colitis. Johns Hopkins Med J. 1981 Jul;149(1):6–9. [PubMed]
  • Bartlett JG, Chang TW, Gurwith M, Gorbach SL, Onderdonk AB. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridia. N Engl J Med. 1978 Mar 9;298(10):531–534. [PubMed]
  • Brefort G, Magot M, Ionesco H, Sebald M. Characterization and transferability of Clostridium perfringens plasmids. Plasmid. 1977 Nov;1(1):52–66. [PubMed]
  • Chang TW, Bartlett JG, Taylor NS. Clostridium difficile toxin. Pharmacol Ther. 1981;13(3):441–452. [PubMed]
  • Cudmore MA, Silva J, Jr, Fekety R, Liepman MK, Kim KH. Clostridium difficile colitis associated with cancer chemotherapy. Arch Intern Med. 1982 Feb;142(2):333–335. [PubMed]
  • Dzink J, Bartlett JG. In vitro susceptibility of Clostridium difficile isolates from patients with antibiotic-associated diarrhea or colitis. Antimicrob Agents Chemother. 1980 Apr;17(4):695–698. [PMC free article] [PubMed]
  • Franke AE, Clewell DB. Evidence for a chromosome-borne resistance transposon (Tn916) in Streptococcus faecalis that is capable of "conjugal" transfer in the absence of a conjugative plasmid. J Bacteriol. 1981 Jan;145(1):494–502. [PMC free article] [PubMed]
  • George WL, Sutter VL, Goldstein EJ, Ludwig SL, Finegold SM. Aetiology of antimicrobial-agent-associated colitis. Lancet. 1978 Apr 15;1(8068):802–803. [PubMed]
  • Guerry P, LeBlanc DJ, Falkow S. General method for the isolation of plasmid deoxyribonucleic acid. J Bacteriol. 1973 Nov;116(2):1064–1066. [PMC free article] [PubMed]
  • Horodniceanu T, Bougueleret L, Bieth G. Conjugative transfer of multiple-antibiotic resistance markers in beta-hemolytic group A, B, F, and G streptococci in the absence of extrachromosomal deoxyribonucleic acid. Plasmid. 1981 Mar;5(2):127–137. [PubMed]
  • Larson HE, Price AB, Honour P, Borriello SP. Clostridium difficile and the aetiology of pseudomembranous colitis. Lancet. 1978 May 20;1(8073):1063–1066. [PubMed]
  • Laughon BE, Syed SA, Loesche WJ. API ZYM system for identification of Bacteroides spp., Capnocytophaga spp., and spirochetes of oral origin. J Clin Microbiol. 1982 Jan;15(1):97–102. [PMC free article] [PubMed]
  • Macrina FL, Mays TK, Smith CJ, Welch RA. Non-plasmid associated transfer of antibiotic resistance in Bacteroides. J Antimicrob Chemother. 1981 Dec;8 (Suppl 500):77–86. [PubMed]
  • Mays TD, Smith CJ, Welch RA, Delfini C, Macrina FL. Novel antibiotic resistance transfer in Bacteroides. Antimicrob Agents Chemother. 1982 Jan;21(1):110–118. [PMC free article] [PubMed]
  • McHugh GL, Swartz MN. Elimination of plasmids from several bacterial species by novobiocin. Antimicrob Agents Chemother. 1977 Sep;12(3):423–426. [PMC free article] [PubMed]
  • Nakamura S, Nakashio S, Mikawa M, Yamakawa K, Okumura S, Nishida S. Antimicrobial susceptibility of Clostridium difficile from different sources. Microbiol Immunol. 1982;26(1):25–30. [PubMed]
  • Privitera G, Sebald M, Fayolle F. Common regulatory mechanism of expression and conjugative ability of a tetracycline resistance plasmid in Bacteroides fragilis. Nature. 1979 Apr 12;278(5705):657–659. [PubMed]
  • Smith CJ, Markowitz SM, Macrina FL. Transferable tetracycline resistance in Clostridium difficile. Antimicrob Agents Chemother. 1981 Jun;19(6):997–1003. [PMC free article] [PubMed]
  • Smith MD, Guild WR. Improved method for conjugative transfer by filter mating of Streptococcus pneumoniae. J Bacteriol. 1980 Oct;144(1):457–459. [PMC free article] [PubMed]
  • Tally FP, Snydman DR, Gorbach SL, Malamy MH. Plasmid-mediated, transferable resistance to clindamycin and erythromycin in Bacteroides fragilis. J Infect Dis. 1979 Jan;139(1):83–88. [PubMed]
  • Tytgat F. Fréquence d'isolement de Clostridium difficile dans les selles de malades hospitalisés: sensibilité aux antibiotiques des souches isolées. Ann Microbiol (Paris) 1980 Jul-Aug;131B(1):11–20. [PubMed]
  • Welch RA, Jones KR, Macrina FL. Transferable lincosamide-macrolide resistance in Bacteroides. Plasmid. 1979 Apr;2(2):261–268. [PubMed]

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