Logo of bmjLink to Publisher's site
BMJ. 1989 Mar 4; 298(6673): 564–567.
PMCID: PMC1835925

Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease.

Abstract

In national samples of 9921 10 year olds and 3259 adults in Britain systolic blood pressure was inversely related to birth weight. The association was independent of gestational age and may therefore be attributed to reduced fetal growth. This suggests that the intrauterine environment influences blood pressure during adult life. It is further evidence that the geographical differences in average blood pressure and mortality from cardiovascular disease in Britain partly reflect past differences in the intrauterine environment. Within England and Wales 10 year olds living in areas with high cardiovascular mortality were shorter and had higher resting pulse rates than those living in other areas. Their mothers were also shorter and had higher diastolic blood pressures. This suggests that there are persisting geographical differences in the childhood environment that predispose to differences in cardiovascular mortality.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (941K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • HEALY MJ, LOCKHART RD, MACKENZIE JD, TANNER JM, WHITEHOUSE RH. Aberdeen growth study. I. The prediction of adult body measurements from measurements taken each year from birth to 5 years. Arch Dis Child. 1956 Oct;31(159):372–381. [PMC free article] [PubMed]
  • Waaler HT. Height, weight and mortality. The Norwegian experience. Acta Med Scand Suppl. 1984;679:1–56. [PubMed]
  • Marmot MG, Shipley MJ, Rose G. Inequalities in death--specific explanations of a general pattern? Lancet. 1984 May 5;1(8384):1003–1006. [PubMed]
  • Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet. 1986 May 10;1(8489):1077–1081. [PubMed]
  • Barker DJ, Osmond C. Death rates from stroke in England and Wales predicted from past maternal mortality. Br Med J (Clin Res Ed) 1987 Jul 11;295(6590):83–86. [PMC free article] [PubMed]
  • Butler NR, Golding J, Haslum M, Stewart-Brown S. Recent findings from the 1970 child health and education study: preliminary communication. J R Soc Med. 1982 Oct;75(10):781–784. [PMC free article] [PubMed]
  • Wadsworth ME, Cripps HA, Midwinter RE, Colley JR. Blood pressure in a national birth cohort at the age of 36 related to social and familial factors, smoking, and body mass. Br Med J (Clin Res Ed) 1985 Nov 30;291(6508):1534–1538. [PMC free article] [PubMed]
  • Szklo M. Epidemiologic patterns of blood pressure in children. Epidemiol Rev. 1979;1:143–169. [PubMed]
  • Gennser G, Rymark P, Isberg PE. Low birth weight and risk of high blood pressure in adulthood. Br Med J (Clin Res Ed) 1988 May 28;296(6635):1498–1500. [PMC free article] [PubMed]
  • Rose G. Sick individuals and sick populations. Int J Epidemiol. 1985 Mar;14(1):32–38. [PubMed]
  • BAIRD D, THOMSON AM, BILLEWICZ WZ. Birth weights and placental weights in pre-eclampsia. J Obstet Gynaecol Br Emp. 1957 Jun;64(3):370–372. [PubMed]
  • Zinner SH, Rosner B, Oh W, Kass EH. Significance of blood pressure in infancy. Familial aggregation and predictive effect on later blood pressure. Hypertension. 1985 May-Jun;7(3 Pt 1):411–416. [PubMed]
  • Ounsted MK, Cockburn JM, Moar VA, Redman CW. Factors associated with the blood pressures of children born to women who were hypertensive during pregnancy. Arch Dis Child. 1985 Jul;60(7):631–635. [PMC free article] [PubMed]
  • Shaper AG, Pocock SJ, Walker M, Cohen NM, Wale CJ, Thomson AG. British Regional Heart Study: cardiovascular risk factors in middle-aged men in 24 towns. Br Med J (Clin Res Ed) 1981 Jul 18;283(6285):179–186. [PMC free article] [PubMed]
  • Whincup PH, Cook DG, Shaper AG, Macfarlane DJ, Walker M. Blood pressure in British children: associations with adult blood pressure and cardiovascular mortality. Lancet. 1988 Oct 15;2(8616):890–893. [PubMed]
  • Ounsted M. Letter: Familial trends in low birth weight. Br Med J. 1974 Oct 19;4(5937):163–163. [PMC free article] [PubMed]
  • Little RE. Mother's and father's birthweight as predictors of infant birthweight. Paediatr Perinat Epidemiol. 1987 Apr;1(1):19–31. [PubMed]

Articles from BMJ : British Medical Journal are provided here courtesy of BMJ Group

Formats:

Save items

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Cited in Books
    Cited in Books
    NCBI Bookshelf books that cite the current articles.
  • MedGen
    MedGen
    Related information in MedGen
  • PubMed
    PubMed
    PubMed citations for these articles

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...