pmc logo image
Logo of aacAntimicrob Agents Chemother SubscriptionsAntimicrob Agents Chemother Web Site
Journal List > Antimicrob Agents Chemother > v.20(6); Dec 1981

Formats:
Antimicrob Agents Chemother. 1981 December; 20(6): 800–802.
PMCID: PMC181801
Copyright notice
Amoxicillin-clavulanic acid in treatment of urinary tract infection due to gram-negative bacteria resistant to penicillin.
R Martinelli, A A Lopes, M M de Oliveira, and H Rocha
Small right arrow pointing to: This article has been cited by other articles in PMC.
Abstract
Twenty-two adult patients with urinary tract infections caused by penicillin-resistant bacteria completed treatment with amoxicillin alone or amoxicillin plus clavulanic acid in a randomized double-blind clinical trial. Of the 13 patients treated with amoxicillin plus clavulanic acid, the absence of bacteriuria within 7 days of therapy was observed in 85%, as compared with only 25% of the 8 patients receiving amoxicillin only. There were no significant side effects nor any clinical, biochemical, or hematological abnormalities related to either treatment. It was concluded that the combination of clavulanic acid and amoxicillin could be useful in the treatment of uncomplicated urinary tract infection caused by penicillin-resistant bacteria.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (438K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
 
icon of scanned page 800
800
icon of scanned page 801
801
icon of scanned page 802
802
 
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Bauer AW, Kirby WM, Sherris JC, Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed]
  • Hunter PA, Coleman K, Fisher J, Taylor D. In vitro synergistic properties of clavulanic acid, with ampicillin, amoxycillin and ticarcillin. J Antimicrob Chemother. 1980 Jul;6(4):455–470. [PubMed]
  • Jackson RT, Harris LF, Alford RH. Sodium clavulanate potentiation of cephalosporin activity against clinical isolates of cephalothin-resistant Klebsiella pneumoniae. Antimicrob Agents Chemother. 1978 Jul;14(1):118–125. [PubMed]
  • Labia R, Peduzzi J. Cinetique de l'inhibition de beta-lactamases par l'acide clavulanique. Biochim Biophys Acta. 1978 Oct 12;526(2):572–579. [PubMed]
  • Paisley JW, Washington JA., 2nd Combined activitiy of clavulanic acid and ticarcillin against ticarcillin-resistant, gram-negative bacilli. Antimicrob Agents Chemother. 1978 Aug;14(2):224–227. [PubMed]
  • Reading C, Cole M. Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother. 1977 May;11(5):852–857. [PubMed]
  • Reading C, Hepburn P. The inhibition of staphylococcal beta-lactamase by clavulanic acid. Biochem J. 1979 Apr 1;179(1):67–76. [PubMed]
  • STAMEY TA, GOVAN DE, PALMER JM. THE LOCALIZATION AND TREATMENT OF URINARY TRACT INFECTIONS: THE ROLE OF BACTERICIDAL URINE LEVELS AS OPPOSED TO SERUM LEVELS. Medicine (Baltimore). 1965 Jan;44:1–36. [PubMed]
  • Turck M, Ronald AR, Petersdorf RG. Relapse and reinfection in chronic bacteriuria. II. The correlation between site of infection and pattern of recurrence in chronic bacteriuria. N Engl J Med. 1968 Feb 22;278(8):422–427. [PubMed]
  • Wise R, Andrews JM, Bedford KA. In vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillin. Antimicrob Agents Chemother. 1978 Mar;13(3):389–393. [PubMed]
Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of
American Society for Microbiology (ASM)

PubMed articles by these authors