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Journal List > Antimicrob Agents Chemother > v.30(6); Dec 1986

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Antimicrob Agents Chemother. 1986 December; 30(6): 953–954.
PMCID: PMC180629
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Comparative efficacy of ketoconazole and mebendazole in experimental trichinosis.
J A Hess, P H Chandrasekar, M Mortiere, and J A Molinari
Abstract
The therapeutic efficacy of ketoconazole and mebendazole was studied in ICR/CD-1 mice infected with Trichinella spiralis for 17 to 20 weeks. Efficacy of both drugs was over 70% when compared with results in control mice. This study indicates that both ketoconazole and mebendazole should be considered in the treatment of trichinosis in humans.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
  • Berman JD. Activity of imidazoles against Leishmania tropica in human macrophage cultures. Am J Trop Med Hyg. 1981 May;30(3):566–569. [PubMed]
  • Fernando SS, Deham DA. The effects of mebendazole and fenbendazole on Trichinella spiralis in mice. J Parasitol. 1976 Dec;62(6):874–876. [PubMed]
  • Friedman PA, Platzer EG. Interaction of anthelmintic benzimidazoles with Ascaris suum embryonic tubulin. Biochim Biophys Acta. 1980 Jun 19;630(2):271–278. [PubMed]
  • Levin ML. Treatment of trichinosis with mebendazole. Am J Trop Med Hyg. 1983 Sep;32(5):980–983. [PubMed]
  • McCabe RE, Araujo FG, Remington JS. Ketoconazole protects against infection with Trypanosoma cruzi in a murine model. Am J Trop Med Hyg. 1983 Sep;32(5):960–962. [PubMed]
  • McCracken RO, Taylor DD. Mebendazole therapy of parenteral trichinellosis. Science. 1980 Mar 14;207(4436):1220–1222. [PubMed]
  • Negroni R, Robles AM, Arechavala A, Tuculet MA, Galimberti R. Ketoconazole in the treatment of paracoccidioidomycosis and histoplasmosis. Rev Infect Dis. 1980 Jul–Aug;2(4):643–649. [PubMed]
  • Pfaller MA, Krogstad DJ. Imidazole and polyene activity against chloroquine-resistant Plasmodium falciparum. J Infect Dis. 1981 Oct;144(4):372–375. [PubMed]
  • Sonnet JJ, Thienpont D. The treatment of trichinosis with mebendazole. Acta Clin Belg. 1977;32(5):297–302. [PubMed]
  • Urcuyo FG, Zaias N. Oral ketoconazole in the treatment of leishmaniasis. Int J Dermatol. 1982 Sep;21(7):414–416. [PubMed]
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