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Antimicrob Agents Chemother. 1986 June; 29(6): 986–991. | PMCID: PMC180489 |
Anticandidal activities of terconazole, a broad-spectrum antimycotic. E L Tolman, D M Isaacson, M E Rosenthale, J L McGuire, J Van Cutsem, M Borgers, and H Van den Bossche Abstract Terconazole is a new triazole ketal derivative with broad-spectrum in vitro and in vivo antifungal activities. This study further characterizes the effects of terconazole in vitro on yeast cell growth, viability, and morphology. Terconazole inhibited the growth of Candida albicans ATCC 44859 in a concentration-related manner, but with modest effects noted at levels from 10(-8) to 10(-5) M when the yeast was grown on media favoring the cell form. The inhibitory potency of terconazole on yeast cell viability varied with the strain and species of Candida tested. The susceptibility of C. albicans ATCC 44859 to terconazole was markedly enhanced when the yeast was grown on Eagle minimum essential medium, which favors mycelium formation. The effects of terconazole on the morphology of yeast cells (grown on Eagle minimum essential medium) were shown by phase-contrast and electron microscopy. There is a progression of changes, from loss of mycelia formation at 10(-8) M terconazole through complete necrosis at 10(-4) M. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. Images in this article Click on the image to see a larger version. These references are in PubMed. This may not be the complete list of references from this article. - Aerts F, De Brabander M, van den Bossche H, van Cutsem J, Borgers M. The activity of ketoconazole in mixed cultures of fungi and human fibroblasts. Mykosen. 1980 Feb;23(2):53–67. [PubMed]
- Borgers M, De Brabander M, Van Den Bossche H, Van Cutsem J. Promotion of pseudomycelium formation of Candida albicans in culture: a morphological study of the effects of miconazole and ketoconazole. Postgrad Med J. 1979 Sep;55(647):687–691. [PubMed]
- Borgers M, De Nollin S. The preservation of subcellular organelles of Candida albicans with conventional fixatives. J Cell Biol. 1974 Aug;62(2):574–581. [PubMed]
- Odds FC. Laboratory evaluation of antifungal agents: a comparative study of five imidazole derivatives of clinical importance. J Antimicrob Chemother. 1980 Nov;6(6):749–761. [PubMed]
- Van Cutsem J, Van Gerven F, Zaman R, Janssen PA. Terconazole - a new broad-spectrum antifungal. Chemotherapy. 1983;29(5):322–331. [PubMed]
- Van den Bossche H. Biochemical effects of miconazole on fungi. I. Effects on the uptake and or utilization of purines, pyrimidines, nucleosides, amino acids and glucose by Candida albicans. Biochem Pharmacol. 1974 Feb 15;23(4):887–899. [PubMed]
- Van den Bossche H, Ruysschaert JM, Defrise-Quertain F, Willemsens G, Cornelissen F, Marichal P, Cools W, Van Cutsem J. The interaction of miconazole and ketoconazole with lipids. Biochem Pharmacol. 1982 Aug 15;31(16):2609–2617. [PubMed]
- Van Den Bossche H, Willemsens G, Cools W, Cornelissen F. Inhibition of ergosterol synthesis in Candida albicans by ketoconazole [proceedings]. Arch Int Physiol Biochim. 1979 Oct;87(4):849–851. [PubMed]
- van den Bossche H, Willemsens G, Cools W, Lauwers WF, Le Jeune L. Biochemical effects of miconazole on fungi. II. Inhibition of ergosterol biosynthesis in Candida albicans. Chem Biol Interact. 1978 Apr;21(1):59–78. [PubMed]
- Van Den Bossche H, Willemsens G, Van Cutsem JM. The action of miconazole of the growth of Candida albicans. Sabouraudia. 1975 Mar;13(Pt 1):63–73. [PubMed]
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