|
|
Antimicrob Agents Chemother. 1985 April; 27(4): 652–654. | PMCID: PMC180116 |
Comparison of single-dose tetracycline hydrochloride to conventional therapy of urinary tract infections. J Rosenstock, L P Smith, M Gurney, K Lee, W G Weinberg, J N Longfield, W B Tauber, and W W Karney Abstract Sixty-two women with signs and symptoms compatible with lower urinary tract infections were randomized to receive single-dose tetracycline (2 g), multi-dose tetracycline (500 mg four times per day for 10 days), or single-dose amoxicillin (3 g). Urine cultures were obtained upon entry into the study and on days 4, 14, and 28 after therapy. Single-dose tetracycline cured 12 of 16 (75%) of women with documented urinary tract infections, compared with 15 of 16 (94%) in the multi-dose tetracycline group and 7 of 13 (54%) receiving single-dose amoxicillin. Mild nausea in 3 of 20 patients (15%) was the only complication in the single-dose tetracycline group. Two grams of single-dose tetracycline is as effective as other reported regimens regardless of the susceptibility of the initial pathogen and has minimal toxicity. Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (568K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References. These references are in PubMed. This may not be the complete list of references from this article. - Buckwold FJ, Ludwig P, Harding GK, Thompson L, Slutchuk M, Shaw J, Ronald AR. Therapy for acute cystitis in adult women. Randomized comparison of single-dose sulfisoxazole vs trimethoprim-sulfamethoxazole. JAMA. 1982 Apr 2;247(13):1839–1842. [PubMed]
- Cornelius CE., 3rd Six-city study of treatment of gonorrhoea in men using single oral doses of 1.5 or 3 g. tetracycline hydrochloride. Br J Vener Dis. 1970 Aug;46(4):330–333. [PubMed]
- DuPont HL, Hornick RB. Clinical approach to infectious diarrheas. Medicine (Baltimore). 1973 Jul;52(4):265–270. [PubMed]
- Fairley KF, Whitworth JA, Kincaid-Smith P, Durman O. Single-dose therapy in management of urinary tract infection. Med J Aust. 1978 Jul 15;2(2):75–76. [PubMed]
- Fang LS, Tolkoff-Rubin NE, Rubin RH. Efficacy of single-dose and conventional amoxicillin therapy in urinary-tract infection localized by the antibody-coated bacteria technic. N Engl J Med. 1978 Feb 23;298(8):413–416. [PubMed]
- Greenberg RN, Sanders CV, Lewis AC, Marier RL. Single-dose cefaclor therapy of urinary tract infection. Evaluation of antibody-coated bacteria test and C-reactive protein assay as predictors of cure. Am J Med. 1981 Nov;71(5):841–845. [PubMed]
- Karney WW, Pedersen AH, Nelson M, Adams H, Pfeifer RT, Holmes KK. Spectinomycin versus tetracycline for the treatment of gonorrhea. N Engl J Med. 1977 Apr 21;296(16):889–894. [PubMed]
- Kunin CM. Duration of treatment of urinary tract infections. Am J Med. 1981 Nov;71(5):849–854. [PubMed]
- Matuscak RR, Pasculle AW, Barnhart L, Atchison RW, Yee RB. Slide method for detection of antibody-coated bacteria in urine sediments. J Clin Microbiol. 1980 Dec;12(6):761–763. [PubMed]
- McLone DG, Billings TE, Hardegree WE, Hackney JF. Gonorrhoea in females treated with one oral dose of tetracycline. Br J Vener Dis. 1968 Sep;44(3):218–219. [PubMed]
- Neu HC. A symposium on the tetracyclines: a major appraisal. Introduction. Bull N Y Acad Med. 1978 Feb;54(2):141–155. [PubMed]
- Pickering LK, DuPont HL, Olarte J. Single-dose tetracycline therapy for shigellosis in adults. JAMA. 1978 Feb 27;239(9):853–854. [PubMed]
- Pontzer RE, Krieger RE, Boscia JA, McNamee W, Levison ME, Kaye D. Single-dose cefonicid therapy for urinary tract infections. Antimicrob Agents Chemother. 1983 Jun;23(6):814–816. [PubMed]
- Ronald AR, Boutros P, Mourtada H. Bacteriuria localization and response to single-dose therapy in women. JAMA. 1976 Apr 26;235(17):1854–1856. [PubMed]
- Rubin RH, Fang LS, Jones SR, Munford RS, Slepack JM, Varga PA, Onheiber L, Hall CL, Tolkoff-Rubin NE. Single-dose amoxicillin therapy for urinary tract infection. Multicenter trial using antibody-coated bacteria localization technique. JAMA. 1980 Aug 8;244(6):561–564. [PubMed]
- Sabath LD. Tetracyclines in the treatment of genitourinary tract infections. Bull N Y Acad Med. 1978 Feb;54(2):205–215. [PubMed]
- Savard-Fenton M, Fenton BW, Reller LB, Lauer BA, Byyny RL. Single-dose amoxicillin therapy with follow-up urine culture. Effective initial management for acute uncomplicated urinary tract infections. Am J Med. 1982 Dec;73(6):808–813. [PubMed]
- Souney P, Polk BF. Single-dose antimicrobial therapy for urinary tract infections in women. Rev Infect Dis. 1982 Jan–Feb;4(1):29–34. [PubMed]
- Stamm WE, Counts GW, Running KR, Fihn S, Turck M, Holmes KK. Diagnosis of coliform infection in acutely dysuric women. N Engl J Med. 1982 Aug 19;307(8):463–468. [PubMed]
- Stamm WE, Running K, McKevitt M, Counts GW, Turck M, Holmes KK. Treatment of the acute urethral syndrome. N Engl J Med. 1981 Apr 16;304(16):956–958. [PubMed]
- Tolkoff-Rubin NE, Weber D, Fang LS, Kelly M, Wilkinson R, Rubin RH. Single-dose therapy with trimethoprim-sulfamethoxazole for urinary tract infection in women. Rev Infect Dis. 1982 Mar–Apr;4(2):444–448. [PubMed]
|
This article has been