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Table 1

Features of the inactive X territory

Xist RNALong functional RNA initiates silencing in cis
PcG proteinsPRC2 (Eed, Ezh2, Suz12) PRC1 (Bmi-1, Phc1, Phc2, Cbx2, Cbx7, Ring1a, Ring1b)
ModificationsHistone H3 Lys27 trimethylation (by PRC2) Histone H2A Lys119 ubiquitination (by PRC1) Histone H4 Lys20 monomethylation Histone H3 Lys9 dimethylation Histone H4 hypoacetylation
Histone variantsMacroH2A Histone H1
Other proteinsSAF-A (nuclear matrix-associated) BRCA1
FeaturesExclusion of RNA polymerase II Late replication Exclusion of histone H2ABbd

BRCA1, breast cancer 1; PcG, Polycomb group proteins; PRC, Polycomb-repressive complex; SAF-A, scaffold attachment factor-A.