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Infect Dis Obstet Gynecol. 2001; 9(1): 9–15. doi: 10.1155/S1064744901000035. | PMCID: PMC1784633 |
Copyright © 2001 Hindawi Publishing Corporation. Efficacy of Clindamycin Vaginal Ovule (3-Day Treatment) vs.
Clindamycin Vaginal Cream (7-Day Treatment) in Bacterial Vaginosis Jack Sobel,  1 Jeffrey F. Peipert, 2 James A. McGregor, 3 Charles Livengood, 4 Maureen Martin, 5 Jill Robbins, 5 and Charles P. Wajszczuk 51 Division of Infectious Diseases, Detroit Medical Center, Wayne State University School of
Medicine, 3990 John R. Street, Detroit, MI, 48201, USA, 2 Women and Infants Hospital, Brown University School of Medicine, Providence, RI, USA, 3 Denver Health Medical Center, Denver, CO, USA, 4 Duke University Medical Center, Durham, NC, USA, 5 Pharmacia and Upjohn, Kalamazoo, MI, USA, Received December 1, 1999; Accepted November 30, 2000. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objective: To compare the efficacy and safety of a 3-day regimen of clindamycin vaginal ovules with a 7-day
regimen of clindamycin vaginal cream for the treatment of bacterial vaginosis (BV) Methods: Women with a clinical diagnosis of BV were treated with a 3-day course of clindamycin ovules or a 7-day
course of clindamycin cream administered intravaginally. Three hundred and eighty-four patients received study
drug and were included in the evaluable patient population (ovule group, n = 204; cream group, n = 180).
Assessments included pelvic examination and diagnostic testing. Primary efficacy endpoints were a resolution of
two of three diagnostic criteria at the first follow-up visit and three of three diagnostic criteria at the second. Results: Cure rates in the evaluable patient population were similar between treatment groups: 53.7% (109/204)
for the ovule group and 47.8% (85/180) for the cream group (p = 0.2471, 95% CI– 4.1–16.0%). The most
commonly reported medical event, vulvovaginal pruritus, had similar incidence in both treatment groups. Conclusions: A 3-day course of clindamycin vaginal ovules is as effective and well-tolerated as a 7-day course of
clindamycin vaginal cream in the treatment of BV. The Full Text of this article is available as a PDF (334K). These references are in PubMed. This may not be the complete list of references from this article. - Sobel JD. Vaginitis. N Engl J Med. 1997 Dec 25;337(26):1896–1903. [PubMed]
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