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Br J Pharmacol. Nov 1974; 52(3): 419–425.
PMCID: PMC1777004

Reversal learning enhanced by lysergic acid diethylamide (LSD)

Concomitant rise in brain 5-hydroxytryptamine levels

Abstract

1 Small doses of lysergic acid diethylamide (LSD) (12.5-50 μg/kg) consistently facilitated learning of a brightness discrimination reversal.

2 2-Bromo-lysergic acid diethylamide (BOL-148), a structural analogue of LSD, with similar peripheral anti-5-hydroxytrypamine activity but no psychotomimetic properties, had no effect in this learning situation at a similar dose (25 μg/kg).

3 LSD, but not BOL-148, caused a small but significant increase in brain 5-hydroxytryptamine levels, but had no effect on the levels of catecholamines in the brain at 25 μg/kg.

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Selected References

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