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J Bacteriol. 1996 Jan; 178(1): 321–324.
PMCID: PMC177660

Autoregulation of iclR, the gene encoding the repressor of the glyoxylate bypass operon.


The aceBAK operon was partially induced by a multicopy plasmid which carried the promoter region of the gene which encodes its repressor, iclR. Gel shift and DNase I analyses demonstrated that IclR binds to its own promoter. Disruption of iclR increased the expression of an iclR::lacZ operon fusion. Although aceBAK and iclR are both regulated by IclR, aceBAK expression responds to the carbon source, while expression of iclR does not.

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