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Figure 2

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 Exuberant immunoblastic pattern of lymphadenopathy in adult onset Still’s disease seen in (A–C) patient 9 and (D–F) patient 10. (A) Patchy areas effaced by large atypical cells. Haematoxylin and eosin (H&E) stain; original magnification, ×40. (B) Large immunoblastic cells showing vesicular nuclei with prominent nucleoli, eosinophilic cytoplasm, and frequent mitoses. H&E stain; original magnification, ×400. (C) High Ki-67 expression in immunoblastic cells. Immunoperoxidase stain; original magnification, ×400. (D) Loosely aggregated large immunoblastic cells effacing the entire lymph node architecture. H&E stain; original magnification, ×400. (E) CD3 expression in most of the large immunoblastic cells. Immunoperoxidase stain; original magnification, ×400. (F) Ki-1 expression in many of the immunoblastic cells with a membranous and Golgi staining pattern. Immunoperoxidase stain; original magnification, ×400.

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