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Figure 1

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Schematic representation of cytotoxic T lymphocyte (CTL) induced apoptosis signalling pathways. When released into the cytoplasm of the target cell, granzyme B can activate caspase 3, both directly and indirectly, by truncation of the proapoptotic bcl-2 family member Bid (t-Bid), resulting in activation of the caspase 9 mediated pathway. Ligation of the FAS death receptor by CTL secreted FAS ligand will result in activation of caspase 8, again resulting in activation of caspase 3 with execution of apoptosis.