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Multiple pathways contribute to the pathogenesis of Huntington disease
Shihua Li, Xiao-Jiang Li
Mol Neurodegener. 2006; 1: 19. Published online 2006 December 16. doi: 10.1186/1750-1326-1-19
PMCID:
PMC1764744
Abstract Full Text PDF–422K

Is Cited by the Following 20 Articles in this Archive:

Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases
P. Hemachandra Reddy, Tejaswini P. Reddy
Curr Alzheimer Res. Author manuscript; available in PMC 2012 March 6.
Published in final edited form as: Curr Alzheimer Res. 2011 June; 8(4): 393–409.
PMCID:
PMC3295247
Abstract Full Text PDF–1.5M
Proteasomal dysfunction in aging and Huntington disease
Xiao-Jiang Li, Shihua Li
Neurobiol Dis. Author manuscript; available in PMC 2012 July 1.
Published in final edited form as: Neurobiol Dis. 2011 July; 43(1): 4–8. Published online 2010 December 8. doi: 10.1016/j.nbd.2010.11.018
PMCID:
PMC3090713
Free in PMC on 2012/07/01
pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking
Raúl Pardo, Maria Molina-Calavita, Ghislaine Poizat, Guy Keryer, Sandrine Humbert, Frédéric Saudou
Mol Brain. 2010; 3: 17. Published online 2010 June 1. doi: 10.1186/1756-6606-3-17
PMCID:
PMC2887845
Abstract Full Text PDF–1.7M Supplementary Material
Comprehensive Behavioral Testing in the R6/2 Mouse Model of Huntington's Disease Shows No Benefit from CoQ10 or Minocycline
Liliana B. Menalled, Monica Patry, Natalie Ragland, Phillip A. S. Lowden, Jennifer Goodman, Jennie Minnich, Benjamin Zahasky, Larry Park, Janet Leeds, David Howland, Ethan Signer, Allan J. Tobin, Daniela Brunner
PLoS One. 2010; 5(3): e9793. Published online 2010 March 22. doi: 10.1371/journal.pone.0009793
PMCID:
PMC2842438
Abstract Full Text PDF–991K
Mutant Huntingtin in Glial Cells Exacerbates Neurological Symptoms of Huntington Disease Mice
Jennifer Bradford, Ji-Yeon Shin, Meredith Roberts, Chuan-En Wang, Guoqing Sheng, Shihua Li, Xiao-Jiang Li
J Biol Chem. 2010 April 2; 285(14): 10653–10661. Published online 2010 February 9. doi: 10.1074/jbc.M109.083287
PMCID:
PMC2856273
Abstract Full Text Supplementary Material
Monkey hybrid stem cells develop cellular features of Huntington's disease
Chuti Laowtammathron, Eric CH Cheng, Pei-Hsun Cheng, Brooke R Snyder, Shang-Hsun Yang, Zach Johnson, Chanchao Lorthongpanich, Hung-Chih Kuo, Rangsun Parnpai, Anthony WS Chan
BMC Cell Biol. 2010; 11: 12. Published online 2010 February 5. doi: 10.1186/1471-2121-11-12
PMCID:
PMC2833146
Abstract Full Text PDF–2.6M
Huntingtin Interacts with the Cue Domain of gp78 and Inhibits gp78 Binding to Ubiquitin and p97/VCP
Hui Yang, Chao Liu, Yongwang Zhong, Shouqing Luo, Mervyn J. Monteiro, Shengyun Fang
PLoS One. 2010; 5(1): e8905. Published online 2010 January 26. doi: 10.1371/journal.pone.0008905
PMCID:
PMC2811200
Abstract Full Text PDF–1.2M Supplementary Material
Serines 13 and 16 Are Critical Determinants of Full-length Human Mutant Huntingtin-Induced Disease Pathogenesis in HD Mice
Xiaofeng Gu, Erin R. Greiner, Rakesh Mishra, Ravindra Kodali, Alex Osmand, Steven Finkbeiner, Joan S. Steffan, Leslie Michels Thompson, Ronald Wetzel, X. William Yang
Neuron. Author manuscript; available in PMC 2010 December 24.
Published in final edited form as: Neuron. 2009 December 24; 64(6): 828–840. doi: 10.1016/j.neuron.2009.11.020
PMCID:
PMC2807408
Abstract Full Text PDF–3.0M Supplementary Material
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms
Jennifer Bradford, Ji-Yeon Shin, Meredith Roberts, Chuan-En Wang, Xiao-Jiang Li, Shihua Li
Proc Natl Acad Sci U S A. 2009 December 29; 106(52): 22480–22485. Published online 2009 December 11. doi: 10.1073/pnas.0911503106
PMCID:
PMC2799722
Abstract Full Text PDF–1.4M Supplementary Material
Activation of Gene Transcription by Heat Shock Protein 27 May Contribute to Its Neuronal Protection
Meyer J. Friedman, Shihua Li, Xiao-Jiang Li
J Biol Chem. 2009 October 9; 284(41): 27944–27951. Published online 2009 August 5. doi: 10.1074/jbc.M109.037937
PMCID:
PMC2788846
Abstract Full Text
Impaired mitochondrial trafficking in Huntington's disease
Xiao-Jiang Li, Adam L. Orr, Shihua Li
Biochim Biophys Acta. Author manuscript; available in PMC 2011 January 1.
Published in final edited form as: Biochim Biophys Acta. 2010 January; 1802(1): 62–65. Published online 2009 July 8. doi: 10.1016/j.bbadis.2009.06.008
PMCID:
PMC2790549
Abstract Full Text PDF–49K
Mitochondrial Structural and Functional Dynamics in Huntington’s Disease
P. Hemachandra Reddy, Peizhong Mao, Maria Manczak
Brain Res Rev. Author manuscript; available in PMC 2010 June 1.
Published in final edited form as: Brain Res Rev. 2009 June; 61(1): 33–48. Published online 2009 April 24. doi: 10.1016/j.brainresrev.2009.04.001
PMCID:
PMC2748129
Abstract Full Text PDF–1.2M
Calcium signaling and neurodegenerative diseases
Ilya Bezprozvanny
Trends Mol Med. Author manuscript; available in PMC 2011 November 30.
Published in final edited form as: Trends Mol Med. 2009 March; 15(3): 89–100. Published online 2009 February 21. doi: 10.1016/j.molmed.2009.01.001
PMCID:
PMC3226745
Abstract Full Text PDF–2.5M
The gene coding for PGC-1α modifies age at onset in Huntington's Disease
Patrick Weydt, Selma M Soyal, Cinzia Gellera, Stefano DiDonato, Claus Weidinger, Hannes Oberkofler, G Bernhard Landwehrmeyer, Wolfgang Patsch
Mol Neurodegener. 2009; 4: 3. Published online 2009 January 8. doi: 10.1186/1750-1326-4-3
PMCID:
PMC2630305
Abstract Full Text PDF–289K
Differential Activities of the Ubiquitin-Proteasome System in Neurons versus Glia May Account for the Preferential Accumulation of Misfolded Proteins in Neurons
Suzanne Tydlacka, Chuan-En Wang, Xuejun Wang, Shihua Li, Xiao-Jiang Li
J Neurosci. Author manuscript; available in PMC 2009 March 30.
Published in final edited form as: J Neurosci. 2008 December 3; 28(49): 13285–13295. doi: 10.1523/JNEUROSCI.4393-08.2008
PMCID:
PMC2662777
Abstract Full Text PDF–3.2M Supplementary Material
Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases
Xiang Li, He Li, Xiao-Jiang Li
Brain Res Rev. Author manuscript; available in PMC 2009 November 1.
Published in final edited form as: Brain Res Rev. 2008 November; 59(1): 245–252. Published online 2008 August 23. doi: 10.1016/j.brainresrev.2008.08.003
PMCID:
PMC2577582
Abstract Full Text PDF–59K
Mitochondrial Medicine for Aging and Neurodegenerative Diseases
P. Hemachandra Reddy
Neuromolecular Med. Author manuscript; available in PMC 2011 December 12.
Published in final edited form as: Neuromolecular Med. 2008; 10(4): 291–315. Published online 2008 June 20. doi: 10.1007/s12017-008-8044-z
PMCID:
PMC3235551
Abstract Full Text PDF–4.6M
Impaired ubiquitin–proteasome system activity in the synapses of Huntington's disease mice
Jianjun Wang, Chuan-En Wang, Adam Orr, Suzanne Tydlacka, Shi-Hua Li, Xiao-Jiang Li
J Cell Biol. 2008 March 24; 180(6): 1177–1189. doi: 10.1083/jcb.200709080
PMCID:
PMC2290845
Abstract Full Text PDF–6.8M
N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking
Adam L. Orr, Shihua Li, Chuan-En Wang, He Li, Jianjun Wang, Juan Rong, Xingshun Xu, Pier Giorgio Mastroberardino, J. Timothy Greenamyre, Xiao-Jiang Li
J Neurosci. Author manuscript; available in PMC 2009 March 6.
Published in final edited form as: J Neurosci. 2008 March 12; 28(11): 2783–2792. doi: 10.1523/JNEUROSCI.0106-08.2008
PMCID:
PMC2652473
Abstract Full Text PDF–2.2M Supplementary Material
Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease
Xiaofeng Gu, Véronique M André, Carlos Cepeda, Shi-Hua Li, Xiao-Jiang Li, Michael S Levine, X William Yang
Mol Neurodegener. 2007; 2: 8. Published online 2007 April 30. doi: 10.1186/1750-1326-2-8
PMCID:
PMC1885431
Abstract Full Text PDF–2.4M
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