• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of aacPermissionsJournals.ASM.orgJournalAAC ArticleJournal InfoAuthorsReviewers
Antimicrob Agents Chemother. Jul 1990; 34(7): 1387–1389.
PMCID: PMC175986

Oral ofloxacin therapy of Pseudomonas aeruginosa sepsis in mice after irradiation.

Abstract

Death subsequent to whole-body irradiation is associated with gram-negative bacterial sepsis. The effect of oral therapy with the new quinolone ofloxacin for orally acquired Pseudomonas aeruginosa infection was tested in B6D2F1 mice exposed to 7.0 Gy of bilateral radiation from 60Co. A dose of 10(7) organisms was given orally 2 days after irradiation, and therapy was started 1 day later. Only 4 of 20 untreated mice (20%) survived for at least 30 days compared with 19 of 20 mice (95%) treated with ofloxacin (P less than 0.005). P. aeruginosa was isolated from the livers of 21 to 28 untreated mice (75%), compared with only 2 of 30 treated mice (P less than 0.005). Ofloxacin reduced colonization of the ileum by P. aeruginosa; 24 of 28 untreated mice (86%) harbored the organisms, compared with only 5 of 30 (17%) with ofloxacin (P less than 0.005). This experiment was replicated twice, and similar results were obtained. These data illustrate the efficacy of the quinolone ofloxacin for oral therapy of orally acquired P. aeruginosa infection in irradiated hosts.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (693K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Brook I, MacVittie TJ, Walker RI. Recovery of aerobic and anaerobic bacteria from irradiated mice. Infect Immun. 1984 Oct;46(1):270–271. [PMC free article] [PubMed]
  • Brook I, Walker RI, MacVittie TJ. Effect of antimicrobial therapy on bowel flora and bacterial infection in irradiated mice. Int J Radiat Biol Relat Stud Phys Chem Med. 1988 May;53(5):709–716. [PubMed]
  • Dekker AW, Rozenberg-Arska M, Verhoef J. Infection prophylaxis in acute leukemia: a comparison of ciprofloxacin with trimethoprim-sulfamethoxazole and colistin. Ann Intern Med. 1987 Jan;106(1):7–11. [PubMed]
  • Gale RP. Immediate medical consequences of nuclear accidents. Lessons from Chernobyl. JAMA. 1987 Aug 7;258(5):625–628. [PubMed]
  • HAMMOND CW, RUML DD, COOPER DB, MILLER CP. Studies on susceptibility to infection following ionizing radiation. III. Susceptibility of the intestinal tract to oral inoculation with Pseudomonas aeruginosa. J Exp Med. 1955 Oct 1;102(4):403–411. [PMC free article] [PubMed]
  • Hathorn JW, Rubin M, Pizzo PA. Empirical antibiotic therapy in the febrile neutropenic cancer patient: clinical efficacy and impact of monotherapy. Antimicrob Agents Chemother. 1987 Jul;31(7):971–977. [PMC free article] [PubMed]
  • KAPLAN HS, SPECK RS, JAWETZ E. Impairment of antimicrobial defense following total body irradiation of mice. J Lab Clin Med. 1952 Nov;40(5):682–691. [PubMed]
  • Karp JE, Merz WG, Hendricksen C, Laughon B, Redden T, Bamberger BJ, Bartlett JG, Saral R, Burke PJ. Oral norfloxacin for prevention of gram-negative bacterial infections in patients with acute leukemia and granulocytopenia. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1987 Jan;106(1):1–7. [PubMed]
  • Kern W, Kurrle E, Vanek E. Ofloxacin for prevention of bacterial infections in granulocytopenic patients. Infection. 1987 Nov-Dec;15(6):427–433. [PubMed]
  • Leleux A, Snoeck R, Gerain J, Van der Auwera P, Daneau D, Meunier F. Prévention par la péfloxacine des infections chez les malades cancéreux granulocytopéniques. Presse Med. 1989 Jan 7;18(1):21–24. [PubMed]
  • Maki DG. Nosocomial bacteremia. An epidemiologic overview. Am J Med. 1981 Mar;70(3):719–732. [PubMed]
  • MILLER CP, HAMMOND CW, TOMPKINS M, SHORTER G. The treatment of postirradiation infection with antibiotics; an experimental study on mice. J Lab Clin Med. 1952 Mar;39(3):462–479. [PubMed]
  • Monk JP, Campoli-Richards DM. Ofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1987 Apr;33(4):346–391. [PubMed]
  • Pecquet S, Andremont A, Tancrède C. Effect of oral ofloxacin on fecal bacteria in human volunteers. Antimicrob Agents Chemother. 1987 Jan;31(1):124–125. [PMC free article] [PubMed]
  • VINCENT JG, VEOMETT RC, RILEY RF. Relation of the indigenous flora of the small intestine of the rat to post-irradiation bacteremia. J Bacteriol. 1955 Jan;69(1):38–44. [PMC free article] [PubMed]
  • Walker RI, Brook I, Costerton JW, MacVittie T, Myhal ML. Possible association of mucous blanket integrity with postirradiation colonization resistance. Radiat Res. 1985 Dec;104(3):346–357. [PubMed]
  • Weinstein MP, Reller LB, Murphy JR, Lichtenstein KA. The clinical significance of positive blood cultures: a comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. I. Laboratory and epidemiologic observations. Rev Infect Dis. 1983 Jan-Feb;5(1):35–53. [PubMed]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...