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Logo of jmedethJournal of Medical EthicsVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
J Med Ethics. Feb 2004; 30(1): 68–72.
PMCID: PMC1757137

Ethical review of health research: a perspective from developing country researchers


Background: Increasing collaboration between industrialised and developing countries in human research studies has led to concerns regarding the potential exploitation of resource deprived countries. This study, commissioned by the former National Bioethics Advisory Commission of the United States, surveyed developing country researchers about their concerns and opinions regarding ethical review processes and the performance of developing country and US international review boards (IRBs).

Methods: Contact lists from four international organisations were used to identify and survey 670 health researchers in developing countries. A questionnaire with 169 questions explored issues of IRB review, informed consent, and recommendations.

Results: The majority of the developing country researchers were middle aged males who were physicians and were employed by educational institutions, carrying out research on part time basis. Forty four percent of the respondents reported that their studies were not reviewed by a developing country IRB or Ministry of Health and one third of these studies were funded by the US. During the review process issues such as the need for local language consent forms and letters for approval, and confidentiality protection of participants were raised by US IRBs in significantly higher proportions than by host country IRBs.

Conclusion: This survey indicates the need for the ethical review of collaborative research in both US and host countries. It also reflects a desire for focused capacity development in supporting ethical review of research.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Angell M. The ethics of clinical research in the Third World. N Engl J Med. 1997 Sep 18;337(12):847–849. [PubMed]
  • Cleaton-Jones PE. An ethical dilemma. Availability of antiretroviral therapy after clinical trials with HIV infected patients are ended. BMJ. 1997 Mar 22;314(7084):887–888. [PMC free article] [PubMed]
  • Barry M. Ethical considerations of human investigation in developing countries: the AIDS dilemma. N Engl J Med. 1988 Oct 20;319(16):1083–1086. [PubMed]
  • Angell M. Ethical imperialism? Ethics in international collaborative clinical research. N Engl J Med. 1988 Oct 20;319(16):1081–1083. [PubMed]
  • Farmer Paul. Can transnational research be ethical in the developing world? Lancet. 2002 Oct 26;360(9342):1266–1266. [PubMed]
  • Wichman Alison, Smith Janet, Mills Deloris, Sandler Alan L. Collaborative research involving human subjects: a survey of researchers using international single project assurances. IRB. 1997 Jan-Feb;19(1):1–6. [PubMed]
  • Phanuphak P. Ethical issues in studies in Thailand of the vertical transmission of HIV. N Engl J Med. 1998 Mar 19;338(12):834–835. [PubMed]
  • Bayer R. The debate over maternal-fetal HIV transmission prevention trials in Africa, Asia, and the Caribbean: racist exploitation or exploitation of racism? Am J Public Health. 1998 Apr;88(4):567–570. [PMC free article] [PubMed]
  • Annas GJ, Grodin MA. Human rights and maternal-fetal HIV transmission prevention trials in Africa. Am J Public Health. 1998 Apr;88(4):560–563. [PMC free article] [PubMed]
  • Palca J. African AIDS: whose research rules? Science. 1990 Oct 12;250(4978):199–201. [PubMed]
  • Levine RJ. Informed consent: some challenges to the universal validity of the Western model. Law Med Health Care. 1991 Fall-Winter;19(3-4):207–213. [PubMed]
  • Wilmshurst P. Scientific imperialism. BMJ. 1997 Mar 22;314(7084):840–841. [PMC free article] [PubMed]
  • Gostin L. Ethical principles for the conduct of human subject research: population-based research and ethics. Law Med Health Care. 1991 Fall-Winter;19(3-4):191–201. [PubMed]

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