• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of jepicomhInstructions for authorsCurrent TOCJournal of Epidemiology and Community Health
J Epidemiol Community Health. Jan 2004; 58(1): 18–23.
PMCID: PMC1757023

Traffic related air pollution and incidence of childhood asthma: results of the Vesta case-control study

Abstract

Study objective: The Vesta project aims to assess the role of traffic related air pollution in the occurrence of childhood asthma.

Design and setting: Case-control study conducted in five French metropolitan areas between 1998 and 2000. A set of 217 pairs of matched 4 to 14 years old cases and controls were investigated. An index of lifelong exposure to traffic exhausts was constructed, using retrospective information on traffic density close to all home and school addresses since birth; this index was also calculated for the 0–3 years age period to investigate the effect of early exposures.

Main results: Adjusted on environmental tobacco smoke, personal and parental allergy, and several confounders, lifelong exposure was not associated with asthma. In contrast, associations before age of 3 were significant: odds ratios for tertiles 2 and 3 of the exposure index, relative to tertile 1, exhibited a positive trend (1.48 (95%CI = 0.7 to 3.0) and 2.28 (1.1 to 4.6)), with greater odds ratios among subjects with positive skin prick tests.

Conclusions: These results suggest that traffic related pollutants might have contributed to the asthma epidemic that has taken place during the past decades among children.

Full Text

The Full Text of this article is available as a PDF (321K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Kay AB. Allergy and allergic diseases. First of two parts. N Engl J Med. 2001 Jan 4;344(1):30–37. [PubMed]
  • Woolcock AJ, Peat JK. Evidence for the increase in asthma worldwide. Ciba Found Symp. 1997;206:122–159. [PubMed]
  • Jarvis D, Burney P. ABC of allergies. The epidemiology of allergic disease. BMJ. 1998 Feb 21;316(7131):607–610. [PMC free article] [PubMed]
  • Clark NM, Brown RW, Parker E, Robins TG, Remick DG, Jr, Philbert MA, Keeler GJ, Israel BA. Childhood asthma. Environ Health Perspect. 1999 Jun;107 (Suppl 3):421–429. [PMC free article] [PubMed]
  • Leikauf GD, Kline S, Albert RE, Baxter CS, Bernstein DI, Bernstein J, Buncher CR. Evaluation of a possible association of urban air toxics and asthma. Environ Health Perspect. 1995 Sep;103 (Suppl 6):253–271. [PMC free article] [PubMed]
  • Lau S, Illi S, Sommerfeld C, Niggemann B, Bergmann R, von Mutius E, Wahn U. Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. Multicentre Allergy Study Group. Lancet. 2000 Oct 21;356(9239):1392–1397. [PubMed]
  • Platts-Mills TA, Carter MC, Heymann PW. Specific and nonspecific obstructive lung disease in childhood: causes of changes in the prevalence of asthma. Environ Health Perspect. 2000 Aug;108 (Suppl 4):725–731. [PMC free article] [PubMed]
  • Gold DR. Environmental tobacco smoke, indoor allergens, and childhood asthma. Environ Health Perspect. 2000 Aug;108 (Suppl 4):643–651. [PMC free article] [PubMed]
  • Mattes J, Karmaus W. The use of antibiotics in the first year of life and development of asthma: which comes first? Clin Exp Allergy. 1999 Jun;29(6):729–732. [PubMed]
  • Anderson HR. Air pollution and trends in asthma. Ciba Found Symp. 1997;206:190–207. [PubMed]
  • Ebelt S, Brauer M, Cyrys J, Tuch T, Kreyling WG, Wichmann HE, Heinrich J. Air quality in postunification Erfurt, East Germany: associating changes in pollutant concentrations with changes in emissions. Environ Health Perspect. 2001 Apr;109(4):325–333. [PMC free article] [PubMed]
  • Delfino Ralph J. Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research. Environ Health Perspect. 2002 Aug;110 (Suppl 4):573–589. [PMC free article] [PubMed]
  • Duhme H, Weiland SK, Keil U, Kraemer B, Schmid M, Stender M, Chambless L. The association between self-reported symptoms of asthma and allergic rhinitis and self-reported traffic density on street of residence in adolescents. Epidemiology. 1996 Nov;7(6):578–582. [PubMed]
  • Brunekreef B, Janssen NA, de Hartog J, Harssema H, Knape M, van Vliet P. Air pollution from truck traffic and lung function in children living near motorways. Epidemiology. 1997 May;8(3):298–303. [PubMed]
  • van Vliet P, Knape M, de Hartog J, Janssen N, Harssema H, Brunekreef B. Motor vehicle exhaust and chronic respiratory symptoms in children living near freeways. Environ Res. 1997;74(2):122–132. [PubMed]
  • Wjst M, Reitmeir P, Dold S, Wulff A, Nicolai T, von Loeffelholz-Colberg EF, von Mutius E. Road traffic and adverse effects on respiratory health in children. BMJ. 1993 Sep 4;307(6904):596–600. [PMC free article] [PubMed]
  • Edwards J, Walters S, Griffiths RK. Hospital admissions for asthma in preschool children: relationship to major roads in Birmingham, United Kingdom. Arch Environ Health. 1994 Jul-Aug;49(4):223–227. [PubMed]
  • Ciccone G, Forastiere F, Agabiti N, Biggeri A, Bisanti L, Chellini E, Corbo G, Dell'Orco V, Dalmasso P, Volante TF, et al. Road traffic and adverse respiratory effects in children. SIDRIA Collaborative Group. Occup Environ Med. 1998 Nov;55(11):771–778. [PMC free article] [PubMed]
  • Krämer U, Koch T, Ranft U, Ring J, Behrendt H. Traffic-related air pollution is associated with atopy in children living in urban areas. Epidemiology. 2000 Jan;11(1):64–70. [PubMed]
  • Wyler C, Braun-Fahrländer C, Künzli N, Schindler C, Ackermann-Liebrich U, Perruchoud AP, Leuenberger P, Wüthrich B. Exposure to motor vehicle traffic and allergic sensitization. The Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. Epidemiology. 2000 Jul;11(4):450–456. [PubMed]
  • von Mutius E, Weiland SK, Fritzsch C, Duhme H, Keil U. Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany. Lancet. 1998 Mar 21;351(9106):862–866. [PubMed]
  • Zmirou D, Gauvin S, Pin I, Momas I, Just J, Sahraoui F, Le Moullec Y, Brémont F, Cassadou S, Albertini M, et al. Five epidemiological studies on transport and asthma: objectives, design and descriptive results. J Expo Anal Environ Epidemiol. 2002 May;12(3):186–196. [PubMed]
  • Koistinen KJ, Kousa A, Tenhola V, Hänninen O, Jantunen MJ, Oglesby L, Kuenzli N, Georgoulis L. Fine particle (PM2.5) measurement methodology, quality assurance procedures, and pilot results of the EXPOLIS study. J Air Waste Manag Assoc. 1999 Oct;49(10):1212–1220. [PubMed]
  • Oglesby L, Rotko T, Krütli P, Boudet C, Kruize H, Nen MJ, Künzli N. Personal exposure assessment studies may suffer from exposure-relevant selection bias. J Expo Anal Environ Epidemiol. 2000 May-Jun;10(3):251–266. [PubMed]
  • Venn A, Lewis S, Cooper M, Hubbard R, Hill I, Boddy R, Bell M, Britton J. Local road traffic activity and the prevalence, severity, and persistence of wheeze in school children: combined cross sectional and longitudinal study. Occup Environ Med. 2000 Mar;57(3):152–158. [PMC free article] [PubMed]
  • Pearson RL, Wachtel H, Ebi KL. Distance-weighted traffic density in proximity to a home is a risk factor for leukemia and other childhood cancers. J Air Waste Manag Assoc. 2000 Feb;50(2):175–180. [PubMed]
  • Wilkinson P, Elliott P, Grundy C, Shaddick G, Thakrar B, Walls P, Falconer S. Case-control study of hospital admission with asthma in children aged 5-14 years: relation with road traffic in north west London. Thorax. 1999 Dec;54(12):1070–1074. [PMC free article] [PubMed]
  • Raaschou-Nielsen O, Hertel O, Thomsen BL, Olsen JH. Air pollution from traffic at the residence of children with cancer. Am J Epidemiol. 2001 Mar 1;153(5):433–443. [PubMed]
  • Nyberg F, Gustavsson P, Järup L, Bellander T, Berglind N, Jakobsson R, Pershagen G. Urban air pollution and lung cancer in Stockholm. Epidemiology. 2000 Sep;11(5):487–495. [PubMed]
  • Takano H, Yoshikawa T, Ichinose T, Miyabara Y, Imaoka K, Sagai M. Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice. Am J Respir Crit Care Med. 1997 Jul;156(1):36–42. [PubMed]
  • Diaz-Sanchez D, Tsien A, Fleming J, Saxon A. Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern. J Immunol. 1997 Mar 1;158(5):2406–2413. [PubMed]
  • Diaz-Sanchez D, Dotson AR, Takenaka H, Saxon A. Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms. J Clin Invest. 1994 Oct;94(4):1417–1425. [PMC free article] [PubMed]
  • Martinez FD. Maturation of immune responses at the beginning of asthma. J Allergy Clin Immunol. 1999 Mar;103(3 Pt 1):355–361. [PubMed]
  • Busse WW, Lemanske RF., Jr Asthma. N Engl J Med. 2001 Feb 1;344(5):350–362. [PubMed]
  • Pandya Robert J, Solomon Gina, Kinner Amy, Balmes John R. Diesel exhaust and asthma: hypotheses and molecular mechanisms of action. Environ Health Perspect. 2002 Feb;110 (Suppl 1):103–112. [PMC free article] [PubMed]
  • Peden DB. Development of atopy and asthma: candidate environmental influences and important periods of exposure. Environ Health Perspect. 2000 Jun;108 (Suppl 3):475–482. [PMC free article] [PubMed]

Articles from Journal of Epidemiology and Community Health are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...