• We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Logo of annrheumdAnnals of the Rheumatic DiseasesCurrent TOCInstructions for authors
Ann Rheum Dis. Aug 2005; 64(8): 1109–1111.
PMCID: PMC1755599

The melatonin-cytokine connection in rheumatoid arthritis

Full Text

The Full Text of this article is available as a PDF (58K).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Maestroni GJ. Therapeutic potential of melatonin in immunodeficiency states, viral diseases, and cancer. Adv Exp Med Biol. 1999;467:217–226. [PubMed]
  • Maestroni GJ, Conti A. The pineal neurohormone melatonin stimulates activated CD4+, Thy-1+ cells to release opioid agonist(s) with immunoenhancing and anti-stress properties. J Neuroimmunol. 1990 Jul;28(2):167–176. [PubMed]
  • Wichmann MW, Zellweger R, DeMaso, Ayala A, Chaudry IH. Melatonin administration attenuates depressed immune functions trauma-hemorrhage. J Surg Res. 1996 Jun;63(1):256–262. [PubMed]
  • Maestroni GJ, Covacci V, Conti A. Hematopoietic rescue via T-cell-dependent, endogenous granulocyte-macrophage colony-stimulating factor induced by the pineal neurohormone melatonin in tumor-bearing mice. Cancer Res. 1994 May 1;54(9):2429–2432. [PubMed]
  • Maestroni GJ, Conti A, Lissoni P. Colony-stimulating activity and hematopoietic rescue from cancer chemotherapy compounds are induced by melatonin via endogenous interleukin 4. Cancer Res. 1994 Sep 1;54(17):4740–4743. [PubMed]
  • Nelson RJ, Demas GE. Role of melatonin in mediating seasonal energetic and immunologic adaptations. Brain Res Bull. 1997;44(4):423–430. [PubMed]
  • Rafii-El-Idrissi M, Calvo JR, Harmouch A, García-Mauriño S, Guerrero JM. Specific binding of melatonin by purified cell nuclei from spleen and thymus of the rat. J Neuroimmunol. 1998 Jun 15;86(2):190–197. [PubMed]
  • Yellon SM, Teasley LA, Fagoaga OR, Nguyen HC, Truong HN, Nehlsen-Cannarella L. Role of photoperiod and the pineal gland in T cell-dependent humoral immune reactivity in the Siberian hamster. J Pineal Res. 1999 Nov;27(4):243–248. [PubMed]
  • Kliger CA, Gehad AE, Hulet RM, Roush WB, Lillehoj HS, Mashaly MM. Effects of photoperiod and melatonin on lymphocyte activities in male broiler chickens. Poult Sci. 2000 Jan;79(1):18–25. [PubMed]
  • Moore CB, Siopes TD. Effects of lighting conditions and melatonin supplementation on the cellular and humoral immune responses in Japanese quail Coturnix coturnix japonica. Gen Comp Endocrinol. 2000 Jul;119(1):95–104. [PubMed]
  • Garcia-Mauriño S, Gonzalez-Haba MG, Calvo JR, Rafii-El-Idrissi M, Sanchez-Margalet V, Goberna R, Guerrero JM. Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes. J Immunol. 1997 Jul 15;159(2):574–581. [PubMed]
  • Morrey KM, McLachlan JA, Serkin CD, Bakouche O. Activation of human monocytes by the pineal hormone melatonin. J Immunol. 1994 Sep 15;153(6):2671–2680. [PubMed]
  • García-Mauriño S, Pozo D, Carrillo-Vico A, Calvo JR, Guerrero JM. Melatonin activates Th1 lymphocytes by increasing IL-12 production. Life Sci. 1999;65(20):2143–2150. [PubMed]
  • Petrovsky N, Harrison LC. The chronobiology of human cytokine production. Int Rev Immunol. 1998;16(5-6):635–649. [PubMed]
  • Fiorina P, Lattuada G, Silvestrini C, Ponari O, Dall'Aglio P. Disruption of nocturnal melatonin rhythm and immunological involvement in ischaemic stroke patients. Scand J Immunol. 1999 Aug;50(2):228–231. [PubMed]
  • Nunnari G, Nigro L, Palermo F, Leto D, Pomerantz RJ, Cacopardo B. Reduction of serum melatonin levels in HIV-1-infected individuals' parallel disease progression: correlation with serum interleukin-12 levels. Infection. 2003 Dec;31(6):379–382. [PubMed]
  • Carrillo-Vico Antonio, Calvo Juan R, Abreu Pedro, Lardone Patricia J, García-Mauriño Sofía, Reiter Russel J, Guerrero Juan M. Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance. FASEB J. 2004 Mar;18(3):537–539. [PubMed]
  • Carrillo-Vico Antonio, Lardone Patricia J, Fernández-Santos José M, Martín-Lacave Inés, Calvo Juan R, Karasek Michal, Guerrero Juan M. Human lymphocyte-synthesized melatonin is involved in the regulation of the interleukin-2/interleukin-2 receptor system. J Clin Endocrinol Metab. 2005 Feb;90(2):992–1000. [PubMed]
  • Malek Thomas R, Bayer Allison L. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol. 2004 Sep;4(9):665–674. [PubMed]
  • Nelson Brad H. IL-2, regulatory T cells, and tolerance. J Immunol. 2004 Apr 1;172(7):3983–3988. [PubMed]
  • Maestroni GJ. The immunotherapeutic potential of melatonin. Expert Opin Investig Drugs. 2001 Mar;10(3):467–476. [PubMed]
  • Cutolo M, Villaggio B, Candido F, Valenti S, Giusti M, Felli L, Sulli A, Accardo S. Melatonin influences interleukin-12 and nitric oxide production by primary cultures of rheumatoid synovial macrophages and THP-1 cells. Ann N Y Acad Sci. 1999 Jun 22;876:246–254. [PubMed]
  • García-Mauriño S, Pozo D, Carrillo-Vico A, Calvo JR, Guerrero JM. Melatonin activates Th1 lymphocytes by increasing IL-12 production. Life Sci. 1999;65(20):2143–2150. [PubMed]
  • Lissoni P. Modulation of anticancer cytokines IL-2 and IL-12 by melatonin and the other pineal indoles 5-methoxytryptamine and 5-methoxytryptophol in the treatment of human neoplasms. Ann N Y Acad Sci. 2000;917:560–567. [PubMed]
  • Webster Jeanette I, Tonelli Leonardo, Sternberg Esther M. Neuroendocrine regulation of immunity. Annu Rev Immunol. 2002;20:125–163. [PubMed]
  • Ashwell JD, Lu FW, Vacchio MS. Glucocorticoids in T cell development and function*. Annu Rev Immunol. 2000;18:309–345. [PubMed]
  • Kino Tomoshige, Chrousos George P. Tissue-specific glucocorticoid resistance-hypersensitivity syndromes: multifactorial states of clinical importance. J Allergy Clin Immunol. 2002 Apr;109(4):609–613. [PubMed]
  • Corrigan CJ, Brown PH, Barnes NC, Tsai JJ, Frew AJ, Kay AB. Glucocorticoid resistance in chronic asthma. Peripheral blood T lymphocyte activation and comparison of the T lymphocyte inhibitory effects of glucocorticoids and cyclosporin A. Am Rev Respir Dis. 1991 Nov;144(5):1026–1032. [PubMed]
  • Sher ER, Leung DY, Surs W, Kam JC, Zieg G, Kamada AK, Szefler SJ. Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest. 1994 Jan;93(1):33–39. [PMC free article] [PubMed]
  • Leung DY, de Castro M, Szefler SJ, Chrousos GP. Mechanisms of glucocorticoid-resistant asthma. Ann N Y Acad Sci. 1998 May 1;840:735–746. [PubMed]
  • Walker KB, Potter JM, House AK. Interleukin 2 synthesis in the presence of steroids: a model of steroid resistance. Clin Exp Immunol. 1987 Apr;68(1):162–167. [PMC free article] [PubMed]
  • Maestroni GJ, Conti A, Pierpaoli W. Role of the pineal gland in immunity. Circadian synthesis and release of melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone. J Neuroimmunol. 1986 Nov;13(1):19–30. [PubMed]
  • Maestroni GJ, Conti A, Pierpaoli W. Role of the pineal gland in immunity. III. Melatonin antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism. Immunology. 1988 Mar;63(3):465–469. [PMC free article] [PubMed]
  • Sainz RM, Mayo JC, Reiter RJ, Antolin I, Esteban MM, Rodriguez C. Melatonin regulates glucocorticoid receptor: an answer to its antiapoptotic action in thymus. FASEB J. 1999 Sep;13(12):1547–1556. [PubMed]
  • Sulli A, Maestroni GJM, Villaggio B, Hertens E, Craviotto C, Pizzorni C, Briata M, Seriolo B, Cutolo M. Melatonin serum levels in rheumatoid arthritis. Ann N Y Acad Sci. 2002 Jun;966:276–283. [PubMed]
  • Cutolo Maurizio, Masi Alfonse T. Circadian rhythms and arthritis. Rheum Dis Clin North Am. 2005 Feb;31(1):115–x. [PubMed]
  • Schulze-Koops H, Lipsky PE, Kavanaugh AF, Davis LS. Elevated Th1- or Th0-like cytokine mRNA in peripheral circulation of patients with rheumatoid arthritis. Modulation by treatment with anti-ICAM-1 correlates with clinical benefit. J Immunol. 1995 Nov 15;155(10):5029–5037. [PubMed]
  • Maestroni Georges J M, Sulli Alberto, Pizzorni Carmen, Villaggio Barbara, Cutolo Maurizio. Melatonin in rheumatoid arthritis: synovial macrophages show melatonin receptors. Ann N Y Acad Sci. 2002 Jun;966:271–275. [PubMed]
  • Maestroni GJM, Sulli A, Pizzorni C, Villaggio B, Cutolo M. Melatonin in rheumatoid arthritis: a disease-promoting and modulating hormone? Clin Exp Rheumatol. 2002 Nov-Dec;20(6):872–873. [PubMed]
  • Cantorna MT. Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Proc Soc Exp Biol Med. 2000 Mar;223(3):230–233. [PubMed]
  • Rozin A, Balbir-Gurman A, Schapira D. Seasonal distribution of relapse onset in rheumatoid arthritis and spondyloarthropathy: the possible effect of the solar factor. Clin Exp Rheumatol. 2003 Mar-Apr;21(2):161–169. [PubMed]
  • Cutolo M. Solar light effects on onset/relapses and circannual/circadian symptomatology in rheumatoid arthritis. Clin Exp Rheumatol. 2003 Mar-Apr;21(2):148–150. [PubMed]
  • Cutolo M, Maestroni GJM, Otsa K, Aakre O, Villaggio B, Capellino S, Montagna P, Fazzuoli L, Veldi T, Peets T, et al. Circadian melatonin and cortisol levels in rheumatoid arthritis patients in winter time: a north and south Europe comparison. Ann Rheum Dis. 2005 Feb;64(2):212–216. [PMC free article] [PubMed]
  • Straub RH, Cutolo M. Involvement of the hypothalamic--pituitary--adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role. Arthritis Rheum. 2001 Mar;44(3):493–507. [PubMed]
  • Abdel-Nasser AM, Rasker JJ, Valkenburg HA. Epidemiological and clinical aspects relating to the variability of rheumatoid arthritis. Semin Arthritis Rheum. 1997 Oct;27(2):123–140. [PubMed]
  • Spector TD. Rheumatoid arthritis. Rheum Dis Clin North Am. 1990 Aug;16(3):513–537. [PubMed]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Group

Formats:

Related citations in PubMed

See reviews...See all...

Cited by other articles in PMC

See all...

Links

  • Compound
    Compound
    PubChem Compound links
  • PubMed
    PubMed
    PubMed citations for these articles
  • Substance
    Substance
    PubChem Substance links

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...